Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil

Alvarado-Arnez, Lucia Elena; Batista, Angelica Martins; Alves, Silvia Marinho; Melo, Gloria; Lorena, Virgínia Maria Barros de; Cardoso, Cynthia C.; Pereira, Isabela Resende; Carrazzone, Cristina; Pacheco, Antonio G.; Oliveira Jr., Wilson; Moraes, Milton Ozório; Lannes-Vieira, Joseli

Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil

Detalhes bibliográficos
Autor(a) principal:	Alvarado-Arnez, Lucia Elena
Data de Publicação:	2018
Outros Autores:	Batista, Angelica Martins, Alves, Silvia Marinho, Melo, Gloria, Lorena, Virgínia Maria Barros de, Cardoso, Cynthia C., Pereira, Isabela Resende, Carrazzone, Cristina, Pacheco, Antonio G., Oliveira Jr., Wilson, Moraes, Milton Ozório, Lannes-Vieira, Joseli
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/25790
Resumo:	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ, Brasil.

Metadados do item

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spelling	Alvarado-Arnez, Lucia ElenaBatista, Angelica MartinsAlves, Silvia MarinhoMelo, GloriaLorena, Virgínia Maria Barros deCardoso, Cynthia C.Pereira, Isabela ResendeCarrazzone, CristinaPacheco, Antonio G.Oliveira Jr., WilsonMoraes, Milton OzórioLannes-Vieira, Joseli2018-04-12T11:45:15Z2018-04-12T11:45:15Z2018ALVARADO-ARNEZ, Lucia Elena et al. Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 113, n. 6, p.1-12, 2018.0074-0276https://www.arca.fiocruz.br/handle/icict/2579010.1590/0074-027601704891678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruzhttps://www.arca.fiocruz.br/handle/icict/20995Doença de ChagasTrypanosoma cruziCardiomiopatiaCitocinaspolimorfismo genéticoMetanáliseChagas DiseaseTrypanosoma cruzicardiomyopathyCytokinesgene polymorphismmeta-analysisSingle nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ, Brasil.Ambulatório de Doença de Chagas e Insuficiência Cardíaca do Pronto Socorro Cardiológico de Pernambuco. Recife, PE, Brasil.Ambulatório de Doença de Chagas e Insuficiência Cardíaca do Pronto Socorro Cardiológico de Pernambuco. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Laboratório de Imunoparasitologia. Recife, PE, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ, Brasil.Ambulatório de Doença de Chagas e Insuficiência Cardíaca do Pronto Socorro Cardiológico de Pernambuco. Recife, PE, Brasil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Ambulatório de Doença de Chagas e Insuficiência Cardíaca do Pronto Socorro Cardiológico de Pernambuco. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ, Brasil.The severity of chronic chagasic cardiomyopathy (CCC), the most frequent clinical outcome of Chagas disease (CD), has been associated with cytokine-enriched heart tissue inflammation, and high serum levels of transforming growth factor (TGFβ), interferon-gamma (IFNγ), and tumour necrosis factor (TNF). Conversely, increased interleukin (IL)-10 serum concentrations have been associated with asymptomatic CD. Cytokines and cytokine-related gene polymorphisms may control cytokine expression and have been proposed to contribute to CCC outcomes.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25790/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjoselilannes1_viera_etal_IOC_2018.pdfjoselilannes1_viera_etal_IOC_2018.pdfapplication/pdf570842https://www.arca.fiocruz.br/bitstream/icict/25790/2/joselilannes1_viera_etal_IOC_2018.pdf9990145bed782e1d1204ebe5ea6cabddMD52TEXTjoselilannes1_viera_etal_IOC_2018.pdf.txtjoselilannes1_viera_etal_IOC_2018.pdf.txtExtracted texttext/plain58660https://www.arca.fiocruz.br/bitstream/icict/25790/3/joselilannes1_viera_etal_IOC_2018.pdf.txtc7770d9c9201f12393256112fac0b390MD53icict/257902022-06-24 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dc.title.pt_BR.fl_str_mv	Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil
title	Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil
spellingShingle	Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil Alvarado-Arnez, Lucia Elena Doença de Chagas Trypanosoma cruzi Cardiomiopatia Citocinas polimorfismo genético Metanálise Chagas Disease Trypanosoma cruzi cardiomyopathy Cytokines gene polymorphism meta-analysis
title_short	Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil
title_full	Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil
title_fullStr	Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil
title_full_unstemmed	Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil
title_sort	Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil
author	Alvarado-Arnez, Lucia Elena
author_facet	Alvarado-Arnez, Lucia Elena Batista, Angelica Martins Alves, Silvia Marinho Melo, Gloria Lorena, Virgínia Maria Barros de Cardoso, Cynthia C. Pereira, Isabela Resende Carrazzone, Cristina Pacheco, Antonio G. Oliveira Jr., Wilson Moraes, Milton Ozório Lannes-Vieira, Joseli
author_role	author
author2	Batista, Angelica Martins Alves, Silvia Marinho Melo, Gloria Lorena, Virgínia Maria Barros de Cardoso, Cynthia C. Pereira, Isabela Resende Carrazzone, Cristina Pacheco, Antonio G. Oliveira Jr., Wilson Moraes, Milton Ozório Lannes-Vieira, Joseli
author2_role	author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Alvarado-Arnez, Lucia Elena Batista, Angelica Martins Alves, Silvia Marinho Melo, Gloria Lorena, Virgínia Maria Barros de Cardoso, Cynthia C. Pereira, Isabela Resende Carrazzone, Cristina Pacheco, Antonio G. Oliveira Jr., Wilson Moraes, Milton Ozório Lannes-Vieira, Joseli
dc.subject.other.pt_BR.fl_str_mv	Doença de Chagas Trypanosoma cruzi Cardiomiopatia Citocinas polimorfismo genético Metanálise
topic	Doença de Chagas Trypanosoma cruzi Cardiomiopatia Citocinas polimorfismo genético Metanálise Chagas Disease Trypanosoma cruzi cardiomyopathy Cytokines gene polymorphism meta-analysis
dc.subject.en.pt_BR.fl_str_mv	Chagas Disease Trypanosoma cruzi cardiomyopathy Cytokines gene polymorphism meta-analysis
description	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ, Brasil.
publishDate	2018
dc.date.accessioned.fl_str_mv	2018-04-12T11:45:15Z
dc.date.available.fl_str_mv	2018-04-12T11:45:15Z
dc.date.issued.fl_str_mv	2018
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	ALVARADO-ARNEZ, Lucia Elena et al. Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 113, n. 6, p.1-12, 2018.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/25790
dc.identifier.issn.pt_BR.fl_str_mv	0074-0276
dc.identifier.doi.none.fl_str_mv	10.1590/0074-02760170489
dc.identifier.eissn.none.fl_str_mv	1678-8060
identifier_str_mv	ALVARADO-ARNEZ, Lucia Elena et al. Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 113, n. 6, p.1-12, 2018. 0074-0276 10.1590/0074-02760170489 1678-8060
url	https://www.arca.fiocruz.br/handle/icict/25790
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.uri.none.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/20995
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/25790/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/25790/2/joselilannes1_viera_etal_IOC_2018.pdf https://www.arca.fiocruz.br/bitstream/icict/25790/3/joselilannes1_viera_etal_IOC_2018.pdf.txt
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil

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