Retrovirus infections in a sample of injecting drug users in Rio de Janeiro City, Brazil: prevalence of HIV-1 subtypes, and co-infection with HTLV-I/II.

Guimarães, Monick Lindenmeyer; Bastos, Francisco Inácio Pinkusfeld Monteiro; Telles, Paulo R; Castro Filho, Bernardo Galvão; Diaz, Ricardo Sobhie; Bongertz, Vera; Morgado, Mariza Gonçalves

Retrovirus infections in a sample of injecting drug users in Rio de Janeiro City, Brazil: prevalence of HIV-1 subtypes, and co-infection with HTLV-I/II.

Detalhes bibliográficos
Autor(a) principal:	Guimarães, Monick Lindenmeyer
Data de Publicação:	2001
Outros Autores:	Bastos, Francisco Inácio Pinkusfeld Monteiro, Telles, Paulo R, Castro Filho, Bernardo Galvão, Diaz, Ricardo Sobhie, Bongertz, Vera, Morgado, Mariza Gonçalves
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/8147
Resumo:	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. UNAIDS Collaborative Centre. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil

Metadados do item

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spelling	Guimarães, Monick LindenmeyerBastos, Francisco Inácio Pinkusfeld MonteiroTelles, Paulo RCastro Filho, Bernardo GalvãoDiaz, Ricardo SobhieBongertz, VeraMorgado, Mariza Gonçalves2014-08-07T12:26:46Z2014-08-07T12:26:46Z2001GUIMARÃES, M. L. et al. Retrovirus infections in a sample of injecting drug users in Rio de Janeiro City, Brazil: prevalence of HIV-1 subtypes, and co-infection with HTLV-I/II. Journal of Clinical Virology, v. 21, n. 2, p. 143–151, 2001.1386-6532https://www.arca.fiocruz.br/handle/icict/8147engElsevierRetrovirus infections in a sample of injecting drug users in Rio de Janeiro City, Brazil: prevalence of HIV-1 subtypes, and co-infection with HTLV-I/II.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. UNAIDS Collaborative Centre. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. UNAIDS Collaborative Centre. Center for Information on Science and Technology. Department of Health Information. Rio de Janeiro, RJ, BrasilState Uni versity of Rio de Janeiro. Center for Drug Abuse Treatment and Research. NEPAD. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. UNAIDS Collaborative Centre. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilFederal Uni ersity of São Paulo. Laboratory of Retro virology. São Paulo. SP, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. UNAIDS Collaborative Centre. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. UNAIDS Collaborative Centre. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, BrasilBACKGROUND: Retrovirus infections among injecting drug users (IDUs), a core at-risk population for both HIV-1 and HTLV-I/II infections in Brazil, were assessed within an ongoing cooperative research. OBJECTIVE: The study assessed the seroprevalences of HIV-1 and HTLV-I/II infections, as well as the prevalence of HIV-1 subtypes in a sample of IDUs from Rio de Janeiro, Brazil. An attempt to evaluate HIV incidence was carried out using a dual 'sensitive/less sensitive' testing strategy. STUDY DESIGN: Cross-sectional evaluation of 175 IDUs. Serostatus for HIV-1 and HTLV-I/II were established by enzyme-linked immunosorbent assays, and confirmed by western blot. The dual testing strategy aimed to estimate HIV-1 incidence rates. Differentiation between HTLV-I and -II was performed by western blot. DNA samples were polymerase chain reaction amplified by a nested protocol, and HIV-1 subtyping was determined by heteroduplex mobility assay. RESULTS: Forty-six and 29 samples were found to be, respectively, positive for HIV-1 and HTLV-I/II, 15 of them co-infected by both viruses. Among HTLV-I/II-infected patients, 75.9% were infected by HTLV-I. Thirty-one HIV samples were identified as B subtype, with seven of them showing the typical "Brazilian B" pattern in the gp120 V3 loop, and ten were identified as F subtype. The use of less sensitive assays for HIV infection wrongly identified a deeply immunocompromised patient as an incident case. CONCLUSION: Moderately high seroprevalences were found for both HIV-1 and HTLV-I/II infections, HIV-1/HTLV-I co-infections being of special concern. A non-statistically significant higher prevalence of F subtype was observed, when compared with the distribution of F/B subtypes among Brazilian patients from other exposure categories. No recent HIV-1 infections were detected, but a limitation of the "sensitive/less-sensitive" testing strategy was made evident.Injecting drug usersHIVHTLVHIV/HTLV co-infectionSensitive/less sensitive dual testing strategy for HIV infectionInfecções por HIV/epidemiologiaHIV-1/classificaçãoInfecções por HTLV-I/epidemiologiaAbuso de Substâncias por Via Intravenosa/complicaçõesAdultoBrasil/epidemiologiaEstudos TransversaisFemininoInfecções por HIV/complicaçõesSoroprevalência de HIVInfecções por HTLV-I/complicaçõesHumanosMasculinoIncidênciainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALGuimarães ML Retrovirus infection....pdfGuimarães ML Retrovirus infection....pdfapplication/pdf100575https://www.arca.fiocruz.br/bitstream/icict/8147/1/Guimar%c3%a3es%20ML%20Retrovirus%20infection....pdfe444a5d51c55d26fa663e306de9d716aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8147/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTGuimarães ML Retrovirus infection....pdf.txtGuimarães ML Retrovirus infection....pdf.txtExtracted texttext/plain35095https://www.arca.fiocruz.br/bitstream/icict/8147/3/Guimar%c3%a3es%20ML%20Retrovirus%20infection....pdf.txt7d557e37f98398aad36c0ba3da412e36MD53icict/81472023-08-23 15:29:30.812oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-08-23T18:29:30Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Retrovirus infections in a sample of injecting drug users in Rio de Janeiro City, Brazil: prevalence of HIV-1 subtypes, and co-infection with HTLV-I/II.
title	Retrovirus infections in a sample of injecting drug users in Rio de Janeiro City, Brazil: prevalence of HIV-1 subtypes, and co-infection with HTLV-I/II.
spellingShingle	Retrovirus infections in a sample of injecting drug users in Rio de Janeiro City, Brazil: prevalence of HIV-1 subtypes, and co-infection with HTLV-I/II. Guimarães, Monick Lindenmeyer Injecting drug users HIV HTLV HIV/HTLV co-infection Sensitive/less sensitive dual testing strategy for HIV infection Infecções por HIV/epidemiologia HIV-1/classificação Infecções por HTLV-I/epidemiologia Abuso de Substâncias por Via Intravenosa/complicações Adulto Brasil/epidemiologia Estudos Transversais Feminino Infecções por HIV/complicações Soroprevalência de HIV Infecções por HTLV-I/complicações Humanos Masculino Incidência
title_short	Retrovirus infections in a sample of injecting drug users in Rio de Janeiro City, Brazil: prevalence of HIV-1 subtypes, and co-infection with HTLV-I/II.
title_full	Retrovirus infections in a sample of injecting drug users in Rio de Janeiro City, Brazil: prevalence of HIV-1 subtypes, and co-infection with HTLV-I/II.
title_fullStr	Retrovirus infections in a sample of injecting drug users in Rio de Janeiro City, Brazil: prevalence of HIV-1 subtypes, and co-infection with HTLV-I/II.
title_full_unstemmed	Retrovirus infections in a sample of injecting drug users in Rio de Janeiro City, Brazil: prevalence of HIV-1 subtypes, and co-infection with HTLV-I/II.
title_sort	Retrovirus infections in a sample of injecting drug users in Rio de Janeiro City, Brazil: prevalence of HIV-1 subtypes, and co-infection with HTLV-I/II.
author	Guimarães, Monick Lindenmeyer
author_facet	Guimarães, Monick Lindenmeyer Bastos, Francisco Inácio Pinkusfeld Monteiro Telles, Paulo R Castro Filho, Bernardo Galvão Diaz, Ricardo Sobhie Bongertz, Vera Morgado, Mariza Gonçalves
author_role	author
author2	Bastos, Francisco Inácio Pinkusfeld Monteiro Telles, Paulo R Castro Filho, Bernardo Galvão Diaz, Ricardo Sobhie Bongertz, Vera Morgado, Mariza Gonçalves
author2_role	author author author author author author
dc.contributor.author.fl_str_mv	Guimarães, Monick Lindenmeyer Bastos, Francisco Inácio Pinkusfeld Monteiro Telles, Paulo R Castro Filho, Bernardo Galvão Diaz, Ricardo Sobhie Bongertz, Vera Morgado, Mariza Gonçalves
dc.subject.en.pt_BR.fl_str_mv	Injecting drug users HIV HTLV HIV/HTLV co-infection Sensitive/less sensitive dual testing strategy for HIV infection
topic	Injecting drug users HIV HTLV HIV/HTLV co-infection Sensitive/less sensitive dual testing strategy for HIV infection Infecções por HIV/epidemiologia HIV-1/classificação Infecções por HTLV-I/epidemiologia Abuso de Substâncias por Via Intravenosa/complicações Adulto Brasil/epidemiologia Estudos Transversais Feminino Infecções por HIV/complicações Soroprevalência de HIV Infecções por HTLV-I/complicações Humanos Masculino Incidência
dc.subject.decs.pt_BR.fl_str_mv	Infecções por HIV/epidemiologia HIV-1/classificação Infecções por HTLV-I/epidemiologia Abuso de Substâncias por Via Intravenosa/complicações Adulto Brasil/epidemiologia Estudos Transversais Feminino Infecções por HIV/complicações Soroprevalência de HIV Infecções por HTLV-I/complicações Humanos Masculino Incidência
description	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. UNAIDS Collaborative Centre. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil
publishDate	2001
dc.date.issued.fl_str_mv	2001
dc.date.accessioned.fl_str_mv	2014-08-07T12:26:46Z
dc.date.available.fl_str_mv	2014-08-07T12:26:46Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	GUIMARÃES, M. L. et al. Retrovirus infections in a sample of injecting drug users in Rio de Janeiro City, Brazil: prevalence of HIV-1 subtypes, and co-infection with HTLV-I/II. Journal of Clinical Virology, v. 21, n. 2, p. 143–151, 2001.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/8147
dc.identifier.issn.none.fl_str_mv	1386-6532
identifier_str_mv	GUIMARÃES, M. L. et al. Retrovirus infections in a sample of injecting drug users in Rio de Janeiro City, Brazil: prevalence of HIV-1 subtypes, and co-infection with HTLV-I/II. Journal of Clinical Virology, v. 21, n. 2, p. 143–151, 2001. 1386-6532
url	https://www.arca.fiocruz.br/handle/icict/8147
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
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reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
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Retrovirus infections in a sample of injecting drug users in Rio de Janeiro City, Brazil: prevalence of HIV-1 subtypes, and co-infection with HTLV-I/II.

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