The role of Trypanosoma cruzi and its antigens on the pathogenesis of Chagas's disease myocardiopathy

Detalhes bibliográficos
Autor(a) principal: Andrade, Sonia Gumes
Data de Publicação: 2009
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/48900
Resumo: Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Chagas Experimental, Autoimunidade e Imunologia Celular. Salvador, BA, Brasil.
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spelling Andrade, Sonia Gumes2021-09-01T18:11:31Z2021-09-01T18:11:31Z2009ANDRADE, Sonia Gumes. The role of Trypanosoma cruzi and its antigens on the pathogenesis of Chagas's disease myocardiopathy. Revista da Sociedade Brasileira de Medicina Tropical, v. 42, Supl. II, p. 46-51, 2009.0037-8682https://www.arca.fiocruz.br/handle/icict/48900engSociedade Brasileira de Medicina TropicalTrypanosoma cruziMiocarditisCélulas dendríticasResposta celularResposta imune humoralTrypanosoma cruziMyocarditisDenditric cellsCellular responseHumoral responseCardiomiopatia ChagásicaThe role of Trypanosoma cruzi and its antigens on the pathogenesis of Chagas's disease myocardiopathyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Chagas Experimental, Autoimunidade e Imunologia Celular. Salvador, BA, Brasil.Trypanosoma cruzi infection determines acute disease in the vertebrate host by the intracellular multiplication of parasites, especially within cardiac myocells, which is followed by parasitized host cell destruction and severe myocarditis. The parasite role during the acute phase is therefore evident. This form is followed by an asymptomatic indeterminate form that can be followed by a chronic myocardiopathy (20 - 35% of cases), with scarce parasites. Several authors have suggested an autoimmune mechanism for the chronic phase, with production of autoantibodies and auto-reactive T lymphocites. However, transference of such lymphocites to naïve mice has not met with success. We propose that interstitial dendric cells of the heart (antigens presenting cells) with captured, endocytosed and processed parasite antigens, migrate to the spleen where TCD4 (MHCII restrict) lymphocites are stimulated, inducing the cellular response in Chagas' disease myocarditis. Dendritic follicular cells in the spleen capture and present parasite antigens to splenic B lymphocites (humoral response) with maintenance of the immunological memory.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/48900/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALAndrade. S.G. The role trypanosoma...2009 p. 46-51.PDFAndrade. S.G. The role trypanosoma...2009 p. 46-51.PDFapplication/pdf8414759https://www.arca.fiocruz.br/bitstream/icict/48900/2/Andrade.%20S.G.%20The%20role%20trypanosoma...2009%20p.%2046-51.PDFfb80c842b9ac8bb9726f9e3b5bfd2003MD52TEXTAndrade. S.G. The role trypanosoma...2009 p. 46-51.PDF.txtAndrade. S.G. 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dc.title.en.fl_str_mv The role of Trypanosoma cruzi and its antigens on the pathogenesis of Chagas's disease myocardiopathy
title The role of Trypanosoma cruzi and its antigens on the pathogenesis of Chagas's disease myocardiopathy
spellingShingle The role of Trypanosoma cruzi and its antigens on the pathogenesis of Chagas's disease myocardiopathy
Andrade, Sonia Gumes
Trypanosoma cruzi
Miocarditis
Células dendríticas
Resposta celular
Resposta imune humoral
Trypanosoma cruzi
Myocarditis
Denditric cells
Cellular response
Humoral response
Cardiomiopatia Chagásica
title_short The role of Trypanosoma cruzi and its antigens on the pathogenesis of Chagas's disease myocardiopathy
title_full The role of Trypanosoma cruzi and its antigens on the pathogenesis of Chagas's disease myocardiopathy
title_fullStr The role of Trypanosoma cruzi and its antigens on the pathogenesis of Chagas's disease myocardiopathy
title_full_unstemmed The role of Trypanosoma cruzi and its antigens on the pathogenesis of Chagas's disease myocardiopathy
title_sort The role of Trypanosoma cruzi and its antigens on the pathogenesis of Chagas's disease myocardiopathy
author Andrade, Sonia Gumes
author_facet Andrade, Sonia Gumes
author_role author
dc.contributor.author.fl_str_mv Andrade, Sonia Gumes
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Miocarditis
Células dendríticas
Resposta celular
Resposta imune humoral
topic Trypanosoma cruzi
Miocarditis
Células dendríticas
Resposta celular
Resposta imune humoral
Trypanosoma cruzi
Myocarditis
Denditric cells
Cellular response
Humoral response
Cardiomiopatia Chagásica
dc.subject.en.en.fl_str_mv Trypanosoma cruzi
Myocarditis
Denditric cells
Cellular response
Humoral response
dc.subject.decs.pt_BR.fl_str_mv Cardiomiopatia Chagásica
description Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Chagas Experimental, Autoimunidade e Imunologia Celular. Salvador, BA, Brasil.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2021-09-01T18:11:31Z
dc.date.available.fl_str_mv 2021-09-01T18:11:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Sonia Gumes. The role of Trypanosoma cruzi and its antigens on the pathogenesis of Chagas's disease myocardiopathy. Revista da Sociedade Brasileira de Medicina Tropical, v. 42, Supl. II, p. 46-51, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48900
dc.identifier.issn.pt_BR.fl_str_mv 0037-8682
identifier_str_mv ANDRADE, Sonia Gumes. The role of Trypanosoma cruzi and its antigens on the pathogenesis of Chagas's disease myocardiopathy. Revista da Sociedade Brasileira de Medicina Tropical, v. 42, Supl. II, p. 46-51, 2009.
0037-8682
url https://www.arca.fiocruz.br/handle/icict/48900
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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