Essential oil of Mitracarpus frigidus as a potent source of bioactive compounds

• Autor(a) principal: Fabri, Rodrigo Luiz
• Data de Publicação: 2012
• Outros Autores: Coimbra, Elaine Soares, Almeida, Ana C., Siqueira Filho, Ezequias Pessoa, Alves, Tânia Maria Almeida, Zani, Carlos Leomar, Scio, Elita
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
• Texto Completo: https://www.arca.fiocruz.br/handle/icict/59511; https://doi.org/10.1590/S0001-37652012000400021
• topic: Mitracarpus frigidus; óleo essencial; antimicrobiano; leishmanicida; citotoxidade; Mitracarpus frigidus; ssential oil; antileishmanial; cytotoxicity

In our previous work (Fabri et al. 2009), we showed that different extracts of Mitracarpus frigidus had significant antibacterial, antifungal and leishmanicidal activities. In order to increase our knowledge about this species, this work assesses the chemical composition and the in vitro biological activity of its essential oil. Thus, the essential oil obtained by hydrodistillation of the aerial parts of M. frigidus was analyzed by GC/MS. Among several compounds detected, 11 were identified, being linalool and eugenol acetate the major components. The essential oil exhibited a moderate antibacterial effect against Staphyloccocus aureus, Bacillus cereus, Pseudomonas aeruginosa and Enterobacter cloacae (MIC 250 mu g/mL). On the other hand, it showed a strong antifungal effect against Cryptoccocus neoformans (MIC 8 mu g/mL) and Candida albicans (MIC 63 mu g/mL). Expressive activity against L. major and L. amazonensis promastigote forms with IC50 values of 47.2 and 89.7 mu g/mL, respectively, were also observed. In addition, the antioxidant activity was investigated through DPPH radical-scavenging and showed a significative activity with IC50 of 38 mu g/mL. The cytotoxicity against Artemia salina was moderate with LC50 of 88 mu g/mL. The results presented here are the first report on the chemical composition and biological properties of M. frigidus essential oil