Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18797 |
Resumo: | University of California San Francisco. Sandler Center for Drug Discovery. San Francisco, CA, USA / University of California San Francisco. Department of Pathology. San Francisco, CA, USA. |
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Gunatilleke, Shamila S.Calvet, Claudia M. d'AvilaJohnston, Jonathan B.Chen, Chiung-KuangErenburg, GrigoriGut, JiriEngel, Juan C.Ang, Kenny K. H.Mulvaney, JosephChen, StevenArkin, Michelle R.McKerrow, James H.Podust, Larissa M.2017-05-09T16:19:56Z2017-05-09T16:19:56Z2012GUNATILLEKE, Shamila S. et al. Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51. PLoS Negl Trop Dis, v.6, n.7. e1736, 16p, July 2012.1935-2727https://www.arca.fiocruz.br/handle/icict/1879710.1371/journal.pntd.00017361935-2735engPublic Library of ScienceTrypanosoma cruziDoença de ChagasTrypanosoma cruziChagas DiseaseDiverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of California San Francisco. Sandler Center for Drug Discovery. San Francisco, CA, USA / University of California San Francisco. Department of Pathology. San Francisco, CA, USA.University of California San Francisco. Sandler Center for Drug Discovery. San Francisco, CA, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.University of California San Francisco. Department of Pharmaceutical Chemistry. San Francisco, CA, USA.University of California San Francisco. Sandler Center for Drug Discovery. San Francisco, CA, USA / University of California San Francisco. Department of Pharmaceutical Chemistry. San Francisco, CA, USA.University of Western Ontario. King’s University College. London, Ontario, Canada.University of California San Francisco. Sandler Center for Drug Discovery. San Francisco, CA, USA / University of California San Francisco. Department of Pathology. San Francisco, CA, USA / University of California San Francisco. Department of Medicine. San Francisco, CA, USA.University of California San Francisco. Sandler Center for Drug Discovery. San Francisco, CA, USA / University of California San Francisco. Department of Pathology. San Francisco, CA, USA.University of California San Francisco. Small Molecule Discovery Center. San Francisco, CA, USA.University of California San Francisco. Small Molecule Discovery Center. San Francisco, CA, USA.University of California San Francisco. Small Molecule Discovery Center. San Francisco, CA, USA.University of California San Francisco. Small Molecule Discovery Center. San Francisco, CA, USA.University of California San Francisco. Sandler Center for Drug Discovery. San Francisco, CA, USA / University of California San Francisco. Department of Pathology. San Francisco, CA, USA.University of California San Francisco. Sandler Center for Drug Discovery. San Francisco, CA, USA / University of California San Francisco. Department of Pathology. San Francisco, CA, USA.Chagas Disease, a WHO- and NIH-designated neglected tropical disease, is endemic in Latin America and an emerging infection in North America and Europe as a result of population moves. Although a major cause of morbidity and mortality due to heart failure, as well as inflicting a heavy economic burden in affected regions, Chagas Disease elicits scant notice from the pharmaceutical industry because of adverse economic incentives. The discovery and development of new routes to chemotherapy for Chagas Disease is a clear priority.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18797/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALclaudia_calvet_etal_IOC_2012.pdfclaudia_calvet_etal_IOC_2012.pdfapplication/pdf3309281https://www.arca.fiocruz.br/bitstream/icict/18797/2/claudia_calvet_etal_IOC_2012.pdf51dee8c7003edf1663b0e60c3f2b0747MD52TEXTclaudia_calvet_etal_IOC_2012.pdf.txtclaudia_calvet_etal_IOC_2012.pdf.txtExtracted texttext/plain70422https://www.arca.fiocruz.br/bitstream/icict/18797/3/claudia_calvet_etal_IOC_2012.pdf.txt21dda80b4fe2e3909cee256369749064MD53icict/187972018-08-15 02:12:41.206oai:www.arca.fiocruz.br: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ório 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dc.title.pt_BR.fl_str_mv |
Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51 |
title |
Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51 |
spellingShingle |
Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51 Gunatilleke, Shamila S. Trypanosoma cruzi Doença de Chagas Trypanosoma cruzi Chagas Disease |
title_short |
Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51 |
title_full |
Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51 |
title_fullStr |
Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51 |
title_full_unstemmed |
Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51 |
title_sort |
Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51 |
author |
Gunatilleke, Shamila S. |
author_facet |
Gunatilleke, Shamila S. Calvet, Claudia M. d'Avila Johnston, Jonathan B. Chen, Chiung-Kuang Erenburg, Grigori Gut, Jiri Engel, Juan C. Ang, Kenny K. H. Mulvaney, Joseph Chen, Steven Arkin, Michelle R. McKerrow, James H. Podust, Larissa M. |
author_role |
author |
author2 |
Calvet, Claudia M. d'Avila Johnston, Jonathan B. Chen, Chiung-Kuang Erenburg, Grigori Gut, Jiri Engel, Juan C. Ang, Kenny K. H. Mulvaney, Joseph Chen, Steven Arkin, Michelle R. McKerrow, James H. Podust, Larissa M. |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gunatilleke, Shamila S. Calvet, Claudia M. d'Avila Johnston, Jonathan B. Chen, Chiung-Kuang Erenburg, Grigori Gut, Jiri Engel, Juan C. Ang, Kenny K. H. Mulvaney, Joseph Chen, Steven Arkin, Michelle R. McKerrow, James H. Podust, Larissa M. |
dc.subject.other.pt_BR.fl_str_mv |
Trypanosoma cruzi Doença de Chagas |
topic |
Trypanosoma cruzi Doença de Chagas Trypanosoma cruzi Chagas Disease |
dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Chagas Disease |
description |
University of California San Francisco. Sandler Center for Drug Discovery. San Francisco, CA, USA / University of California San Francisco. Department of Pathology. San Francisco, CA, USA. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2017-05-09T16:19:56Z |
dc.date.available.fl_str_mv |
2017-05-09T16:19:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GUNATILLEKE, Shamila S. et al. Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51. PLoS Negl Trop Dis, v.6, n.7. e1736, 16p, July 2012. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/18797 |
dc.identifier.issn.pt_BR.fl_str_mv |
1935-2727 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0001736 |
dc.identifier.eissn.none.fl_str_mv |
1935-2735 |
identifier_str_mv |
GUNATILLEKE, Shamila S. et al. Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51. PLoS Negl Trop Dis, v.6, n.7. e1736, 16p, July 2012. 1935-2727 10.1371/journal.pntd.0001736 1935-2735 |
url |
https://www.arca.fiocruz.br/handle/icict/18797 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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