Changing Mortality Profile among HIV-Infected Patients in Rio de Janeiro, Brazil: Shifting from AIDS to Non-AIDS Related Conditions in the HAART Era
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/29861 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. |
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Grinsztejn, BeatrizLuz, Paula MendesPacheco, Antonio G.Santos, Desiree V. G.Velasque, LucianeMoreira, Ronaldo I.Guimarães, Maria Regina C.Nunes, Estevão P.Lemos, Alberto S.Ribeiro, Sayonara R.Campos, Dayse P.Vitoria, Marco A. A.Veloso, Valdiléa G.2018-11-05T17:43:36Z2018-11-05T17:43:36Z2013GRINSZTEJN, Beatriz. et al. Changing mortality profile among HIV-infected patients in Rio de Janeiro, Brazil: shifting from AIDS to non-AIDS related conditions in the HAART Era. PloS one, v. 8, n. 4, p. e59768, 2013.1932-6203https://www.arca.fiocruz.br/handle/icict/2986110.1371/journal.pone.0059768engChanging Mortality Profile among HIV-Infected Patients in Rio de Janeiro, Brazil: Shifting from AIDS to Non-AIDS Related Conditions in the HAART Erainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Programa de Computação Cientifica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil./ Universidade Federal do Estado do Rio de Janeiro. Departamento de Matemática e Estatística. Rio de Janeiro, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.World Health Organization. HIV Department. Geneva, SwitzerlandFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.INTRODUCTION: We describe temporal trends in the mortality rates and factors associated with AIDS and non-AIDS related mortality at the Evandro Chagas Clinical Research Institute (IPEC), Oswaldo Cruz Foundation (FIOCRUZ). METHODS: Adult patients enrolling from 1986 through 2009 with a minimum follow up of 60 days were included. Vital status was exhaustively checked using patients' medical charts, through active contact with individuals and family members and by linkage with the Rio de Janeiro Mortality database using a previously validated algorithm. The CoDe protocol was used to establish the cause of death. Extended Cox proportional hazards models were used for multivariate modeling. RESULTS: A total of 3530 individuals met the inclusion criteria, out of which 868 (24.6%) deceased; median follow up per patient was 3.9 years (interquartile range 1.7-9.2 years). The dramatic decrease in the overall mortality rates was driven by AIDS-related causes that decreased from 9.19 deaths/100PYs n 1986-1991 to 1.35/100PYs in 2007-2009. Non-AIDS related mortality rates remained stable overtime, at around 1 death/100PYs. Immunodeficiency significantly increased the hazard of both AIDS-related and non-AIDS-related causes of death, while HAART use was strongly associated with a lower hazard of death from either cause. CONCLUSIONS: Our results confirm the remarkable decrease in AIDS-related mortality as the HIV epidemic evolved and alerts to the conditions not traditionally related to HIV/AIDS which are now becoming more frequent, needing careful monitoring.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/29861/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALChanging Mortality Profile_Beatriz_Griinsztejn_INI_LapClin-AIDS_2013.PDFChanging Mortality Profile_Beatriz_Griinsztejn_INI_LapClin-AIDS_2013.PDFapplication/pdf186137https://www.arca.fiocruz.br/bitstream/icict/29861/2/Changing%20Mortality%20Profile_Beatriz_Griinsztejn_INI_LapClin-AIDS_2013.PDFbc2533344cac4fedce8c3a25ee8437c3MD52TEXTChanging Mortality Profile_Beatriz_Griinsztejn_INI_LapClin-AIDS_2013.PDF.txtChanging Mortality 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| dc.title.pt_BR.fl_str_mv |
Changing Mortality Profile among HIV-Infected Patients in Rio de Janeiro, Brazil: Shifting from AIDS to Non-AIDS Related Conditions in the HAART Era |
| title |
Changing Mortality Profile among HIV-Infected Patients in Rio de Janeiro, Brazil: Shifting from AIDS to Non-AIDS Related Conditions in the HAART Era |
| spellingShingle |
Changing Mortality Profile among HIV-Infected Patients in Rio de Janeiro, Brazil: Shifting from AIDS to Non-AIDS Related Conditions in the HAART Era Grinsztejn, Beatriz |
| title_short |
Changing Mortality Profile among HIV-Infected Patients in Rio de Janeiro, Brazil: Shifting from AIDS to Non-AIDS Related Conditions in the HAART Era |
| title_full |
Changing Mortality Profile among HIV-Infected Patients in Rio de Janeiro, Brazil: Shifting from AIDS to Non-AIDS Related Conditions in the HAART Era |
| title_fullStr |
Changing Mortality Profile among HIV-Infected Patients in Rio de Janeiro, Brazil: Shifting from AIDS to Non-AIDS Related Conditions in the HAART Era |
| title_full_unstemmed |
Changing Mortality Profile among HIV-Infected Patients in Rio de Janeiro, Brazil: Shifting from AIDS to Non-AIDS Related Conditions in the HAART Era |
| title_sort |
Changing Mortality Profile among HIV-Infected Patients in Rio de Janeiro, Brazil: Shifting from AIDS to Non-AIDS Related Conditions in the HAART Era |
| author |
Grinsztejn, Beatriz |
| author_facet |
Grinsztejn, Beatriz Luz, Paula Mendes Pacheco, Antonio G. Santos, Desiree V. G. Velasque, Luciane Moreira, Ronaldo I. Guimarães, Maria Regina C. Nunes, Estevão P. Lemos, Alberto S. Ribeiro, Sayonara R. Campos, Dayse P. Vitoria, Marco A. A. Veloso, Valdiléa G. |
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author |
| author2 |
Luz, Paula Mendes Pacheco, Antonio G. Santos, Desiree V. G. Velasque, Luciane Moreira, Ronaldo I. Guimarães, Maria Regina C. Nunes, Estevão P. Lemos, Alberto S. Ribeiro, Sayonara R. Campos, Dayse P. Vitoria, Marco A. A. Veloso, Valdiléa G. |
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author author author author author author author author author author author author |
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Grinsztejn, Beatriz Luz, Paula Mendes Pacheco, Antonio G. Santos, Desiree V. G. Velasque, Luciane Moreira, Ronaldo I. Guimarães, Maria Regina C. Nunes, Estevão P. Lemos, Alberto S. Ribeiro, Sayonara R. Campos, Dayse P. Vitoria, Marco A. A. Veloso, Valdiléa G. |
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Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. |
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2013 |
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2013 |
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2018-11-05T17:43:36Z |
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2018-11-05T17:43:36Z |
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GRINSZTEJN, Beatriz. et al. Changing mortality profile among HIV-infected patients in Rio de Janeiro, Brazil: shifting from AIDS to non-AIDS related conditions in the HAART Era. PloS one, v. 8, n. 4, p. e59768, 2013. |
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https://www.arca.fiocruz.br/handle/icict/29861 |
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1932-6203 |
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10.1371/journal.pone.0059768 |
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GRINSZTEJN, Beatriz. et al. Changing mortality profile among HIV-infected patients in Rio de Janeiro, Brazil: shifting from AIDS to non-AIDS related conditions in the HAART Era. PloS one, v. 8, n. 4, p. e59768, 2013. 1932-6203 10.1371/journal.pone.0059768 |
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