Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice.

Daltro, Pâmela Santana; Alves, Paula Santana; Castro, Murilo Fagundes de; Azevedo, Carine Machado; Vasconcelos, Juliana Fraga; Allahdadi, Kyan James; Freitas, Luiz Antonio Rodrigues de; Souza, Bruno Solano de Freitas; Santos, Ricardo Ribeiro dos; Soares, Milena Botelho Pereira; Macambira, Simone Garcia

Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice.

Detalhes bibliográficos
Autor(a) principal:	Daltro, Pâmela Santana
Data de Publicação:	2015
Outros Autores:	Alves, Paula Santana, Castro, Murilo Fagundes de, Azevedo, Carine Machado, Vasconcelos, Juliana Fraga, Allahdadi, Kyan James, Freitas, Luiz Antonio Rodrigues de, Souza, Bruno Solano de Freitas, Santos, Ricardo Ribeiro dos, Soares, Milena Botelho Pereira, Macambira, Simone Garcia
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/13255
Resumo:	Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil

Metadados do item

id	CRUZ_b4dcee917e2a4894ce991785f5d23101
oai_identifier_str	oai:www.arca.fiocruz.br:icict/13255
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Daltro, Pâmela SantanaAlves, Paula SantanaCastro, Murilo Fagundes deAzevedo, Carine MachadoVasconcelos, Juliana FragaAllahdadi, Kyan JamesFreitas, Luiz Antonio Rodrigues deSouza, Bruno Solano de FreitasSantos, Ricardo Ribeiro dosSoares, Milena Botelho PereiraMacambira, Simone Garcia2016-03-23T16:47:24Z2016-03-23T16:47:24Z2015DALTRO, P. S. et al. Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice. BMC Cardiovascular Disorders, v. 15, p. 162, 2015.1471-226110.1186/s12872-015-0154-6https://www.arca.fiocruz.br/handle/icict/13255engBioMed CentralAdministration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilHospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilBackground/Objectives: High fat diet (HFD) is a major contributor to the development of obesity and cardiovascular diseases due to the induction of cardiac structural and hemodynamic abnormalities. We used a model of diabetic cardiomyopathy in C57Bl/6 mice fed with a HFD to investigate the effects of granulocyte-colony stimulating factor (G-CSF), a cytokine known for its beneficial effects in the heart, on cardiac anatomical and functional abnormalities associated with obesity and type 2 diabetes. Methods: Groups of C57Bl/6 mice were fed with standard diet (n = 8) or HFD (n = 16). After 36 weeks, HFD animals were divided into a group treated with G-CSF + standard diet (n = 8) and a vehicle control group + standard diet (n = 8). Cardiac structure and function were assessed by electrocardiography, echocardiography and treadmill tests, in addition to the evaluation of body weight, fasting glicemia, insulin and glucose tolerance at different time points. Histological analyses were performed in the heart tissue. Results: HFD consumption induced metabolic alterations characteristic of type 2 diabetes and obesity, as well as cardiac fibrosis and reduced exercise capacity. Upon returning to a standard diet, obese mice body weight returned to non-obese levels. G-CSF administration accelerated the reduction in of body weight in obese mice. Additionally, G-CSF treatment reduced insulin levels, diminished heart fibrosis, increased exercise capacity and reversed cardiac alterations, including bradycardia, elevated QRS amplitude, augmented P amplitude, increased septal wall thickness, left ventricular posterior thickening and cardiac output reduction. Conclusion: Our results indicate that G-CSF administration caused beneficial effects on obesity-associated cardiac impairment.DiabetesDiabetic cardiomyopathyObesityG-CSFDiabetes Mellitus Tipo 2/complicaçõesCardiomiopatias Diabéticas/quimioterapiaFator Estimulador de Colônias de Granulócitos/uso terapêuticoObesidade/complicaçõesAdiponectina/sangueAnimaisGlicemia/metabolismoColesterol/sangueDiabetes Mellitus Tipo 2/patologiaCardiomiopatias Diabéticas/patologiaDieta HiperlipídicaModelos Animais de DoençasFibroseHemodinâmicaInsulina/sangueMasculinoCamundongos Endogâmicos C57BLObesidade/fisiopatologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13255/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALDaltro PS Administration.pdfDaltro PS Administration.pdfapplication/pdf1867804https://www.arca.fiocruz.br/bitstream/icict/13255/2/Daltro%20PS%20Administration.pdffcda37c5e209578598c6bc17baa39bdbMD52TEXTDaltro PS Administration.pdf.txtDaltro PS Administration.pdf.txtExtracted texttext/plain49851https://www.arca.fiocruz.br/bitstream/icict/13255/3/Daltro%20PS%20Administration.pdf.txtcdbb3388bf629535836f7c1cedb3694eMD53icict/132552023-03-15 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dc.title.pt_BR.fl_str_mv	Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice.
title	Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice.
spellingShingle	Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice. Daltro, Pâmela Santana Diabetes Diabetic cardiomyopathy Obesity G-CSF Diabetes Mellitus Tipo 2/complicações Cardiomiopatias Diabéticas/quimioterapia Fator Estimulador de Colônias de Granulócitos/uso terapêutico Obesidade/complicações Adiponectina/sangue Animais Glicemia/metabolismo Colesterol/sangue Diabetes Mellitus Tipo 2/patologia Cardiomiopatias Diabéticas/patologia Dieta Hiperlipídica Modelos Animais de Doenças Fibrose Hemodinâmica Insulina/sangue Masculino Camundongos Endogâmicos C57BL Obesidade/fisiopatologia
title_short	Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice.
title_full	Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice.
title_fullStr	Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice.
title_full_unstemmed	Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice.
title_sort	Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice.
author	Daltro, Pâmela Santana
author_facet	Daltro, Pâmela Santana Alves, Paula Santana Castro, Murilo Fagundes de Azevedo, Carine Machado Vasconcelos, Juliana Fraga Allahdadi, Kyan James Freitas, Luiz Antonio Rodrigues de Souza, Bruno Solano de Freitas Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira Macambira, Simone Garcia
author_role	author
author2	Alves, Paula Santana Castro, Murilo Fagundes de Azevedo, Carine Machado Vasconcelos, Juliana Fraga Allahdadi, Kyan James Freitas, Luiz Antonio Rodrigues de Souza, Bruno Solano de Freitas Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira Macambira, Simone Garcia
author2_role	author author author author author author author author author author
dc.contributor.author.fl_str_mv	Daltro, Pâmela Santana Alves, Paula Santana Castro, Murilo Fagundes de Azevedo, Carine Machado Vasconcelos, Juliana Fraga Allahdadi, Kyan James Freitas, Luiz Antonio Rodrigues de Souza, Bruno Solano de Freitas Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira Macambira, Simone Garcia
dc.subject.en.pt_BR.fl_str_mv	Diabetes Diabetic cardiomyopathy Obesity G-CSF
topic	Diabetes Diabetic cardiomyopathy Obesity G-CSF Diabetes Mellitus Tipo 2/complicações Cardiomiopatias Diabéticas/quimioterapia Fator Estimulador de Colônias de Granulócitos/uso terapêutico Obesidade/complicações Adiponectina/sangue Animais Glicemia/metabolismo Colesterol/sangue Diabetes Mellitus Tipo 2/patologia Cardiomiopatias Diabéticas/patologia Dieta Hiperlipídica Modelos Animais de Doenças Fibrose Hemodinâmica Insulina/sangue Masculino Camundongos Endogâmicos C57BL Obesidade/fisiopatologia
dc.subject.decs.pt_BR.fl_str_mv	Diabetes Mellitus Tipo 2/complicações Cardiomiopatias Diabéticas/quimioterapia Fator Estimulador de Colônias de Granulócitos/uso terapêutico Obesidade/complicações Adiponectina/sangue Animais Glicemia/metabolismo Colesterol/sangue Diabetes Mellitus Tipo 2/patologia Cardiomiopatias Diabéticas/patologia Dieta Hiperlipídica Modelos Animais de Doenças Fibrose Hemodinâmica Insulina/sangue Masculino Camundongos Endogâmicos C57BL Obesidade/fisiopatologia
description	Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil
publishDate	2015
dc.date.issued.fl_str_mv	2015
dc.date.accessioned.fl_str_mv	2016-03-23T16:47:24Z
dc.date.available.fl_str_mv	2016-03-23T16:47:24Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	DALTRO, P. S. et al. Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice. BMC Cardiovascular Disorders, v. 15, p. 162, 2015.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/13255
dc.identifier.issn.none.fl_str_mv	1471-2261 10.1186/s12872-015-0154-6
identifier_str_mv	DALTRO, P. S. et al. Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice. BMC Cardiovascular Disorders, v. 15, p. 162, 2015. 1471-2261 10.1186/s12872-015-0154-6
url	https://www.arca.fiocruz.br/handle/icict/13255
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	BioMed Central
publisher.none.fl_str_mv	BioMed Central
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/13255/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/13255/2/Daltro%20PS%20Administration.pdf https://www.arca.fiocruz.br/bitstream/icict/13255/3/Daltro%20PS%20Administration.pdf.txt
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice.

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