The Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: A Multicenter Prospective Cohort Study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/49901 |
Resumo: | 1Laboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil, 2Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Salvador, Brazil, 3Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil, 4Curso de Medicina, Universidade Salvador, Salvador, Brazil, 5Instituto Brasileiro para Investigação da Tuberculose, Fundação José Silveira, Salvador, Brazil, 6Curso de Medicina, Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil, 7Center of Data and Knowledge Integration for Health, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil, 8Laboratório de Análise e Visualização de Dados, Fundação Oswaldo Cruz, Porto Velho, Brazil, 9Fundação Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil, 10Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil, 11Universidade Federal do Amazonas, Manaus, Brazil, 12Programa Acadêmico de Tuberculose da Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 13Laboratório de Inovações em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil, 14Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA, 15Secretaria Municipal de Saúde do Rio de Janeiro, Rio de Janeiro, Brazil, 16Laboratório de Pesquisa Clínica em Micobacteriose, Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro, Brazil, and 17Universidade Nilton Lins, Manaus, Brazil |
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Arriaga, María B.Pereira, Mariana AraújoDuarte, Beatriz BarretoNogueira, BetâniaFreire, Maria Vitória C. N. S.Queiroz, Artur Trancoso LopoRodrigues, Moreno M. S.Rocha, Michael S.Souza, Alexandra B.Gomes, Renata SpenerCarvalho, Anna Cristina C.Figueiredo, Marina C.Turner, Megan M.Durovni, BetinaSilva, José R. Lapa eKritski, Afrânio L.Cavalcante, SolangeRolla, Valeria C.Santos, Marcelo CordeiroSterling, Timothy R.Andrade, Bruno Bezerril deRegional Prospective Observational Research in Tuberculosis (RePORT)–Brazil Consortium2021-11-19T20:12:19Z2021-11-19T20:12:19Z2021ARRIAGA, María B. et al. The Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: A Multicenter Prospective Cohort Study. Journal of Infectious Diseases, 2021.0022-1899https://www.arca.fiocruz.br/handle/icict/4990110.1093/infdis/jiab4271Laboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil, 2Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Salvador, Brazil, 3Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil, 4Curso de Medicina, Universidade Salvador, Salvador, Brazil, 5Instituto Brasileiro para Investigação da Tuberculose, Fundação José Silveira, Salvador, Brazil, 6Curso de Medicina, Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil, 7Center of Data and Knowledge Integration for Health, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil, 8Laboratório de Análise e Visualização de Dados, Fundação Oswaldo Cruz, Porto Velho, Brazil, 9Fundação Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil, 10Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil, 11Universidade Federal do Amazonas, Manaus, Brazil, 12Programa Acadêmico de Tuberculose da Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 13Laboratório de Inovações em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil, 14Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA, 15Secretaria Municipal de Saúde do Rio de Janeiro, Rio de Janeiro, Brazil, 16Laboratório de Pesquisa Clínica em Micobacteriose, Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro, Brazil, and 17Universidade Nilton Lins, Manaus, BrazilIntramural Research Program of the Fundaçã o Oswaldo Cruz, Intramural Research Program of the Fundação José Silveira, Departamento de Ciência e Tecnologia, Secretaria de Ciência e Tecnologia, Ministério da Saúde, Brazil (25029.000507/2013-07); the Civilian Research and Development Foundation (DAA3-17-63144); and the National Institute of Allergy and Infectious Diseases (U01-AI069923). M. B. A. received a fellowship from the Fundação de Amparo à Pesquisa da Bahia. M. A.-P. and B. B.-D. received a fellowship from Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (finance code: 001). B. B. A., J. R. L.S., and A. L. K. are senior investigators of the Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil."Múltipla ver em Notas"Background. It is unclear whether diabetes or prediabetes affects unfavorable treatment outcomes and death in people with tuberculosis (PWTB). Methods. Culture-confirmed, drug-susceptible PWTB, enrolled in the Regional Prospective Observational Research in Tuberculosis (RePORT)–Brazil cohort between 2015 and 2019 (N = 643) were stratified based on glycemic status according to baseline glycated hemoglobin. Unfavorable tuberculosis (TB) outcome was defined as treatment failure or modification, recurrence, or death; favorable outcome was cure or treatment completion. We corroborated the findings using data from PWTB reported to the Brazilian National System of Diseases Notification (SINAN) during 2015–2019 (N = 20 989). Logistic regression models evaluated associations between glycemic status and outcomes. Results. In both cohorts, in univariate analysis, unfavorable outcomes were more frequently associated with smoking, illicit drug use, and human immunodeficiency virus infection. Diabetes, but not prediabetes, was associated with unfavorable outcomes in the RePORT-Brazil (adjusted relative risk [aRR], 2.45; P < .001) and SINAN (aRR, 1.76; P < .001) cohorts. Furthermore, diabetes was associated with high risk of death (during TB treatment) in both RePORT-Brazil (aRR, 2.16; P = .040) and SINAN (aRR, 1.93; P = .001). Conclusions. Diabetes was associated with an increased risk of unfavorable outcomes and mortality in Brazilian PWTB. Interventions to improve TB treatment outcomes in persons with diabetes are needed.engOxford University PressDiabetesPré-diabetesTratamentoMycobacterium tuberculosisDiabetesPrediabetesTreatment outcomeSINANMycobacterium tuberculosisThe Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: A Multicenter Prospective Cohort Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/49901/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALArriaga, Maria B. The effect of diabetes....pdfArriaga, Maria B. 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| dc.title.pt_BR.fl_str_mv |
The Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: A Multicenter Prospective Cohort Study |
| title |
The Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: A Multicenter Prospective Cohort Study |
| spellingShingle |
The Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: A Multicenter Prospective Cohort Study Arriaga, María B. Diabetes Pré-diabetes Tratamento Mycobacterium tuberculosis Diabetes Prediabetes Treatment outcome SINAN Mycobacterium tuberculosis |
| title_short |
The Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: A Multicenter Prospective Cohort Study |
| title_full |
The Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: A Multicenter Prospective Cohort Study |
| title_fullStr |
The Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: A Multicenter Prospective Cohort Study |
| title_full_unstemmed |
The Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: A Multicenter Prospective Cohort Study |
| title_sort |
The Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: A Multicenter Prospective Cohort Study |
| author |
Arriaga, María B. |
| author_facet |
Arriaga, María B. Pereira, Mariana Araújo Duarte, Beatriz Barreto Nogueira, Betânia Freire, Maria Vitória C. N. S. Queiroz, Artur Trancoso Lopo Rodrigues, Moreno M. S. Rocha, Michael S. Souza, Alexandra B. Gomes, Renata Spener Carvalho, Anna Cristina C. Figueiredo, Marina C. Turner, Megan M. Durovni, Betina Silva, José R. Lapa e Kritski, Afrânio L. Cavalcante, Solange Rolla, Valeria C. Santos, Marcelo Cordeiro Sterling, Timothy R. Andrade, Bruno Bezerril de Regional Prospective Observational Research in Tuberculosis (RePORT)–Brazil Consortium |
| author_role |
author |
| author2 |
Pereira, Mariana Araújo Duarte, Beatriz Barreto Nogueira, Betânia Freire, Maria Vitória C. N. S. Queiroz, Artur Trancoso Lopo Rodrigues, Moreno M. S. Rocha, Michael S. Souza, Alexandra B. Gomes, Renata Spener Carvalho, Anna Cristina C. Figueiredo, Marina C. Turner, Megan M. Durovni, Betina Silva, José R. Lapa e Kritski, Afrânio L. Cavalcante, Solange Rolla, Valeria C. Santos, Marcelo Cordeiro Sterling, Timothy R. Andrade, Bruno Bezerril de Regional Prospective Observational Research in Tuberculosis (RePORT)–Brazil Consortium |
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author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Arriaga, María B. Pereira, Mariana Araújo Duarte, Beatriz Barreto Nogueira, Betânia Freire, Maria Vitória C. N. S. Queiroz, Artur Trancoso Lopo Rodrigues, Moreno M. S. Rocha, Michael S. Souza, Alexandra B. Gomes, Renata Spener Carvalho, Anna Cristina C. Figueiredo, Marina C. Turner, Megan M. Durovni, Betina Silva, José R. Lapa e Kritski, Afrânio L. Cavalcante, Solange Rolla, Valeria C. Santos, Marcelo Cordeiro Sterling, Timothy R. Andrade, Bruno Bezerril de Regional Prospective Observational Research in Tuberculosis (RePORT)–Brazil Consortium |
| dc.subject.other.pt_BR.fl_str_mv |
Diabetes Pré-diabetes Tratamento Mycobacterium tuberculosis |
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Diabetes Pré-diabetes Tratamento Mycobacterium tuberculosis Diabetes Prediabetes Treatment outcome SINAN Mycobacterium tuberculosis |
| dc.subject.en.pt_BR.fl_str_mv |
Diabetes Prediabetes Treatment outcome SINAN Mycobacterium tuberculosis |
| description |
1Laboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil, 2Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Salvador, Brazil, 3Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil, 4Curso de Medicina, Universidade Salvador, Salvador, Brazil, 5Instituto Brasileiro para Investigação da Tuberculose, Fundação José Silveira, Salvador, Brazil, 6Curso de Medicina, Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil, 7Center of Data and Knowledge Integration for Health, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil, 8Laboratório de Análise e Visualização de Dados, Fundação Oswaldo Cruz, Porto Velho, Brazil, 9Fundação Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil, 10Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil, 11Universidade Federal do Amazonas, Manaus, Brazil, 12Programa Acadêmico de Tuberculose da Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 13Laboratório de Inovações em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil, 14Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA, 15Secretaria Municipal de Saúde do Rio de Janeiro, Rio de Janeiro, Brazil, 16Laboratório de Pesquisa Clínica em Micobacteriose, Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro, Brazil, and 17Universidade Nilton Lins, Manaus, Brazil |
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2021 |
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2021-11-19T20:12:19Z |
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2021-11-19T20:12:19Z |
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2021 |
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ARRIAGA, María B. et al. The Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: A Multicenter Prospective Cohort Study. Journal of Infectious Diseases, 2021. |
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https://www.arca.fiocruz.br/handle/icict/49901 |
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0022-1899 |
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10.1093/infdis/jiab427 |
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ARRIAGA, María B. et al. The Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: A Multicenter Prospective Cohort Study. Journal of Infectious Diseases, 2021. 0022-1899 10.1093/infdis/jiab427 |
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Oxford University Press |
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Oxford University Press |
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