Complement System as a Target for Therapies to Control Liver Regeneration/Damage in Acute Liver Failure Induced by Viral Hepatitis

Detalhes bibliográficos
Autor(a) principal: Melgaço, Juliana Gil
Data de Publicação: 2018
Outros Autores: Veloso, Carlos Eduardo, Moreira, Lúcio Filgueiras Pacheco, Vitral, Claudia Lamarca, Pinto, Marcelo Alves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1155/2018/3917032
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31682
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.
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spelling Melgaço, Juliana GilVeloso, Carlos EduardoMoreira, Lúcio Filgueiras PachecoVitral, Claudia LamarcaPinto, Marcelo Alves2019-02-15T15:56:50Z2019-02-15T15:56:50Z2018MELGAÇO, Juliana Gil et al. Complement System as a Target for Therapies to Control Liver Regeneration/Damage in Acute Liver Failure Induced by Viral Hepatitis. Journal of Immunology Research, v. 2018, p. 1-9, Oct. 2018.2314-8861https://www.arca.fiocruz.br/handle/icict/3168210.1155/2018/39170322314-7156engHindawi Publishing CorporationHepatite ViralInsuficiência Hepática AgudaTerapiasControle da Regeneração do FígadoTherapiesViral HepatitisAcute Liver FailureControl Liver RegenerationComplement System as a Target for Therapies to Control Liver Regeneration/Damage in Acute Liver Failure Induced by Viral Hepatitisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Instituto Nacional do Câncer. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Hospital Federal de Bonsucesso. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Microbiologia e Parasitologia. Programa de Pós-graduação em Ciências e Biotecnologia. Laboratório de Virologia Molecular e Biotecnologia Marinha. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.The complement system plays an important role in innate immunity inducing liver diseases as well as signaling immune cell activation in local inflammation regulating immunomodulatory effects such as liver damage and/or liver regeneration. Our aim is to evaluate the role of complement components in acute liver failure (ALF) caused by viral hepatitis, involving virus-induced ALF in human subjects using peripheral blood, samples of liver tissues, and ex vivo assays. Our findings displayed low levels of C3a in plasma samples with high frequency of C3a, C5a, and C5b/9 deposition in liver parenchyma. Meanwhile, laboratory assays using HepG2 (hepatocyte cell line) showed susceptibility to plasma samples from ALF patients impairing in vitro cell proliferation and an increase in apoptotic events submitting plasma samples to heat inactivation. In summary, our data suggest that the complement system may be involved in liver dysfunction in viral-induced acute liver failure cases using ex vivo assays. In extension to our findings, we provide insights into future studies using animal models for viral-induced ALF, as well as other associated soluble components, which need further investigation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31682/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjuliana_melgaço_etal_IOC_2018.pdfjuliana_melgaço_etal_IOC_2018.pdfapplication/pdf1599812https://www.arca.fiocruz.br/bitstream/icict/31682/2/juliana_melga%c3%a7o_etal_IOC_2018.pdfe45378e2c198ae016058562e3da53eeaMD52TEXTjuliana_melgaço_etal_IOC_2018.pdf.txtjuliana_melgaço_etal_IOC_2018.pdf.txtExtracted texttext/plain39380https://www.arca.fiocruz.br/bitstream/icict/31682/3/juliana_melga%c3%a7o_etal_IOC_2018.pdf.txtfc0a7837b43e2ea4fb099e3040b919a0MD53icict/316822023-09-14 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dc.title.pt_BR.fl_str_mv Complement System as a Target for Therapies to Control Liver Regeneration/Damage in Acute Liver Failure Induced by Viral Hepatitis
title Complement System as a Target for Therapies to Control Liver Regeneration/Damage in Acute Liver Failure Induced by Viral Hepatitis
spellingShingle Complement System as a Target for Therapies to Control Liver Regeneration/Damage in Acute Liver Failure Induced by Viral Hepatitis
Melgaço, Juliana Gil
Hepatite Viral
Insuficiência Hepática Aguda
Terapias
Controle da Regeneração do Fígado
Therapies
Viral Hepatitis
Acute Liver Failure
Control Liver Regeneration
title_short Complement System as a Target for Therapies to Control Liver Regeneration/Damage in Acute Liver Failure Induced by Viral Hepatitis
title_full Complement System as a Target for Therapies to Control Liver Regeneration/Damage in Acute Liver Failure Induced by Viral Hepatitis
title_fullStr Complement System as a Target for Therapies to Control Liver Regeneration/Damage in Acute Liver Failure Induced by Viral Hepatitis
title_full_unstemmed Complement System as a Target for Therapies to Control Liver Regeneration/Damage in Acute Liver Failure Induced by Viral Hepatitis
title_sort Complement System as a Target for Therapies to Control Liver Regeneration/Damage in Acute Liver Failure Induced by Viral Hepatitis
author Melgaço, Juliana Gil
author_facet Melgaço, Juliana Gil
Veloso, Carlos Eduardo
Moreira, Lúcio Filgueiras Pacheco
Vitral, Claudia Lamarca
Pinto, Marcelo Alves
author_role author
author2 Veloso, Carlos Eduardo
Moreira, Lúcio Filgueiras Pacheco
Vitral, Claudia Lamarca
Pinto, Marcelo Alves
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Melgaço, Juliana Gil
Veloso, Carlos Eduardo
Moreira, Lúcio Filgueiras Pacheco
Vitral, Claudia Lamarca
Pinto, Marcelo Alves
dc.subject.other.pt_BR.fl_str_mv Hepatite Viral
Insuficiência Hepática Aguda
Terapias
Controle da Regeneração do Fígado
topic Hepatite Viral
Insuficiência Hepática Aguda
Terapias
Controle da Regeneração do Fígado
Therapies
Viral Hepatitis
Acute Liver Failure
Control Liver Regeneration
dc.subject.en.pt_BR.fl_str_mv Therapies
Viral Hepatitis
Acute Liver Failure
Control Liver Regeneration
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-02-15T15:56:50Z
dc.date.available.fl_str_mv 2019-02-15T15:56:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MELGAÇO, Juliana Gil et al. Complement System as a Target for Therapies to Control Liver Regeneration/Damage in Acute Liver Failure Induced by Viral Hepatitis. Journal of Immunology Research, v. 2018, p. 1-9, Oct. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31682
dc.identifier.issn.pt_BR.fl_str_mv 2314-8861
dc.identifier.doi.none.fl_str_mv 10.1155/2018/3917032
dc.identifier.eissn.none.fl_str_mv 2314-7156
identifier_str_mv MELGAÇO, Juliana Gil et al. Complement System as a Target for Therapies to Control Liver Regeneration/Damage in Acute Liver Failure Induced by Viral Hepatitis. Journal of Immunology Research, v. 2018, p. 1-9, Oct. 2018.
2314-8861
10.1155/2018/3917032
2314-7156
url https://www.arca.fiocruz.br/handle/icict/31682
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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