Revisiting the Genetic Ancestry of Brazilians Using Autosomal AIM-Indels
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/12570 |
Resumo: | Universidade do Estado do Rio de Janeiro. Laboratório de Diagnóstica DNA. Rio de Janeiro, RJ, Brasil. |
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Manta, Fernanda Saloum de NevesPereira, RuyVianna, RomuloAraújo, Alfredo Rodolfo Beuttenmüller deGitai, Daniel Leite GóesSilva, Dayse Aparecida daWolfgramm, Eldamária de VargasPontes, Isabel da MotaAguiar, José IvanMoraes, Milton OzórioCarvalho, Elizeu Fagundes deGusmão, Leonor2016-01-21T10:33:13Z2016-01-21T10:33:13Z2013MANTA, Fernanda Saloum de Neves; et al. Revisiting the Genetic Ancestry of Brazilians Using Autosomal AIM-Indels. Plos One, v.8, n.9, e75145, 11p, Sept. 2013.https://www.arca.fiocruz.br/handle/icict/1257010.1371/journal.pone.00751451932-6203engPublic Library of ScienceRevisiting the Genetic Ancestry of Brazilians Using Autosomal AIM-Indelsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Rio de Janeiro. Laboratório de Diagnóstica DNA. Rio de Janeiro, RJ, Brasil.University of Porto (IPATIMUP). Institute of Molecular Pathology and Immunology. Porto, Portugal.Universidade do Estado do Rio de Janeiro. Laboratório de Diagnóstica DNA. Rio de Janeiro, RJ, Brasil.Universidade de Pernambuco. Laboratório de Identificação Humana. Recife, PE, Brasil.Universidade Federal de Alagoas. Instituto de Ciências Biológicas e da Saúde. AL, Brasil.Universidade do Estado do Rio de Janeiro. Laboratório de Diagnóstica DNA. Rio de Janeiro, RJ, Brasil.Universidade Federal do Espírito Santo. Centro de Ciências Humanas e Naturais. Departamento de Ciências Biológicas. Núcleo de Genética Humana e Molecular. Vitória, ES, Brasil.Universidade Federal do Amazonas. Centro de Apoio Multidisciplinar. Laboratório de Diagnóstico Molecular. AM, Brasil.Universidade Federal do Mato Grosso do Sul. Faculdade de Ciências Médicas. Departamento de Medicina Interna. Campo Grande, MS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Laboratório de Diagnóstica DNA. Rio de Janeiro, RJ, Brasil / University of Porto (IPATIMUP). Institute of Molecular Pathology and Immunology. Porto, Portugal.There are many different studies that contribute to the global picture of the ethnic heterogeneity in Brazilian populations. These studies use different types of genetic markers and are focused on the comparison of populations at different levels. In some of them, each geographical region is treated as a single homogeneous population, whereas other studies create different subdivisions: political (e.g., pooling populations by State), demographic (e.g., urban and rural), or ethnic (e.g., culture, self-declaration, or skin colour). In this study, we performed an enhanced reassessment of the genetic ancestry of ~ 1,300 Brazilians characterised for 46 autosomal Ancestry Informative Markers (AIMs). In addition, 798 individuals from twelve Brazilian populations representing the five geographical macro-regions of Brazil were newly genotyped, including a Native American community and a rural Amazonian community. Following an increasing North to South gradient, European ancestry was the most prevalent in all urban populations (with values up to 74%). The populations in the North consisted of a significant proportion of Native American ancestry that was about two times higher than the African contribution. Conversely, in the Northeast, Center-West and Southeast, African ancestry was the second most prevalent. At an intrapopulation level, all urban populations were highly admixed, and most of the variation in ancestry proportions was observed between individuals within each population rather than among population. Nevertheless, individuals with a high proportion of Native American ancestry are only found in the samples from Terena and Santa Isabel. Our results allowed us to further refine the genetic landscape of Brazilians while establishing the basis for the effective application of an autosomal AIM panel in forensic casework and clinical association studies within the highly admixed Brazilian populations.Genetic AncestryBrasilAncestry Informative Markers (AIMs)PopulationEthnic heterogeneityHeterogeneidade GenéticaGenética PopulacionalBrasilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12570/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmilton2_moraes_etal_IOC_2013.pdfmilton2_moraes_etal_IOC_2013.pdfapplication/pdf1626243https://www.arca.fiocruz.br/bitstream/icict/12570/2/milton2_moraes_etal_IOC_2013.pdff85cbee236dd63b4eddea3e8a3eeb821MD52TEXTmilton2_moraes_etal_IOC_2013.pdf.txtmilton2_moraes_etal_IOC_2013.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Revisiting the Genetic Ancestry of Brazilians Using Autosomal AIM-Indels |
| title |
Revisiting the Genetic Ancestry of Brazilians Using Autosomal AIM-Indels |
| spellingShingle |
Revisiting the Genetic Ancestry of Brazilians Using Autosomal AIM-Indels Manta, Fernanda Saloum de Neves Genetic Ancestry Brasil Ancestry Informative Markers (AIMs) Population Ethnic heterogeneity Heterogeneidade Genética Genética Populacional Brasil |
| title_short |
Revisiting the Genetic Ancestry of Brazilians Using Autosomal AIM-Indels |
| title_full |
Revisiting the Genetic Ancestry of Brazilians Using Autosomal AIM-Indels |
| title_fullStr |
Revisiting the Genetic Ancestry of Brazilians Using Autosomal AIM-Indels |
| title_full_unstemmed |
Revisiting the Genetic Ancestry of Brazilians Using Autosomal AIM-Indels |
| title_sort |
Revisiting the Genetic Ancestry of Brazilians Using Autosomal AIM-Indels |
| author |
Manta, Fernanda Saloum de Neves |
| author_facet |
Manta, Fernanda Saloum de Neves Pereira, Ruy Vianna, Romulo Araújo, Alfredo Rodolfo Beuttenmüller de Gitai, Daniel Leite Góes Silva, Dayse Aparecida da Wolfgramm, Eldamária de Vargas Pontes, Isabel da Mota Aguiar, José Ivan Moraes, Milton Ozório Carvalho, Elizeu Fagundes de Gusmão, Leonor |
| author_role |
author |
| author2 |
Pereira, Ruy Vianna, Romulo Araújo, Alfredo Rodolfo Beuttenmüller de Gitai, Daniel Leite Góes Silva, Dayse Aparecida da Wolfgramm, Eldamária de Vargas Pontes, Isabel da Mota Aguiar, José Ivan Moraes, Milton Ozório Carvalho, Elizeu Fagundes de Gusmão, Leonor |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Manta, Fernanda Saloum de Neves Pereira, Ruy Vianna, Romulo Araújo, Alfredo Rodolfo Beuttenmüller de Gitai, Daniel Leite Góes Silva, Dayse Aparecida da Wolfgramm, Eldamária de Vargas Pontes, Isabel da Mota Aguiar, José Ivan Moraes, Milton Ozório Carvalho, Elizeu Fagundes de Gusmão, Leonor |
| dc.subject.en.pt_BR.fl_str_mv |
Genetic Ancestry Brasil Ancestry Informative Markers (AIMs) Population Ethnic heterogeneity |
| topic |
Genetic Ancestry Brasil Ancestry Informative Markers (AIMs) Population Ethnic heterogeneity Heterogeneidade Genética Genética Populacional Brasil |
| dc.subject.decs.pt_BR.fl_str_mv |
Heterogeneidade Genética Genética Populacional Brasil |
| description |
Universidade do Estado do Rio de Janeiro. Laboratório de Diagnóstica DNA. Rio de Janeiro, RJ, Brasil. |
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2013 |
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2013 |
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2016-01-21T10:33:13Z |
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2016-01-21T10:33:13Z |
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MANTA, Fernanda Saloum de Neves; et al. Revisiting the Genetic Ancestry of Brazilians Using Autosomal AIM-Indels. Plos One, v.8, n.9, e75145, 11p, Sept. 2013. |
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https://www.arca.fiocruz.br/handle/icict/12570 |
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10.1371/journal.pone.0075145 |
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1932-6203 |
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MANTA, Fernanda Saloum de Neves; et al. Revisiting the Genetic Ancestry of Brazilians Using Autosomal AIM-Indels. Plos One, v.8, n.9, e75145, 11p, Sept. 2013. 10.1371/journal.pone.0075145 1932-6203 |
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