Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease

Detalhes bibliográficos
Autor(a) principal: Caria, Alex Cleber Improta
Data de Publicação: 2020
Outros Autores: Nonaka, Carolina Kymie Vasques, Cavalcante, Bruno Raphael Ribeiro, Sousa, Ricardo Augusto Leoni de, Aras Júnior, Roque, Souza, Bruno Solano de Freitas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/45859
Resumo: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–Brasil (CAPES)–Finance Code 001.
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spelling Caria, Alex Cleber ImprotaNonaka, Carolina Kymie VasquesCavalcante, Bruno Raphael RibeiroSousa, Ricardo Augusto Leoni deAras Júnior, RoqueSouza, Bruno Solano de Freitas2021-01-28T16:08:00Z2021-01-28T16:08:00Z2020CARIA, Alex Cleber Improta et al. Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease. International Journal of Molecular Sciences, v. 21, p. 1-35, 2020.1661-6596https://www.arca.fiocruz.br/handle/icict/4585910.3390/ijms2114497710.3390/ijms21144977Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–Brasil (CAPES)–Finance Code 001.Federal University of Bahia. Faculty of Medicine. Post-Graduate Program in Medicine and Health. Salvador, BA, Brazil / University Hospital Professor Edgard Santos. Salvador, BA, Brazil / São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil.D’São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Institute for Research and Education. Rio de Janeiro, RJ, Brazil.D’São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Federal University of Valleys´ Jequitinhonha and Mucuri. Physiological Science Multicentric Program. Belo Horizonte, MG, Brazil;Federal University of Bahia. Faculty of Medicine. Post-Graduate Program in Medicine and Health. Salvador, BA, Brazil / University Hospital Professor Edgard Santos. Salvador, BA, Brazil.D’São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Alzheimer disease (AD) is one of the most common neurodegenerative diseases, a ecting middle-aged and elderly individuals worldwide. AD pathophysiology involves the accumulation of beta-amyloid plaques and neurofibrillary tangles in the brain, along with chronic neuroinflammation and neurodegeneration. Physical exercise (PE) is a beneficial non-pharmacological strategy and has been described as an ally to combat cognitive decline in individuals with AD. However, the molecular mechanisms that govern the beneficial adaptations induced by PE in AD are not fully elucidated. MicroRNAs are small non-coding RNAs involved in the post-transcriptional regulation of gene expression, inhibiting or degrading their target mRNAs. MicroRNAs are involved in physiological processes that govern normal brain function and deregulated microRNA profiles are associated with the development and progression of AD. It is also known that PE changes microRNA expression profile in the circulation and in target tissues and organs. Thus, this review aimed to identify the role of deregulated microRNAs in the pathophysiology of AD and explore the possible role of the modulation of microRNAs as a molecular mechanism involved in the beneficial actions of PE in AD.engMDPIDoença de AlzheimerMicroRNAsExercício físicoAlzheimer diseaseMicroRNAsPhysical exerciseModulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/45859/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALCaria Alex Cleber Improta Modulation of....pdfCaria Alex Cleber Improta Modulation 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dc.title.pt_BR.fl_str_mv Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease
title Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease
spellingShingle Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease
Caria, Alex Cleber Improta
Doença de Alzheimer
MicroRNAs
Exercício físico
Alzheimer disease
MicroRNAs
Physical exercise
title_short Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease
title_full Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease
title_fullStr Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease
title_full_unstemmed Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease
title_sort Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease
author Caria, Alex Cleber Improta
author_facet Caria, Alex Cleber Improta
Nonaka, Carolina Kymie Vasques
Cavalcante, Bruno Raphael Ribeiro
Sousa, Ricardo Augusto Leoni de
Aras Júnior, Roque
Souza, Bruno Solano de Freitas
author_role author
author2 Nonaka, Carolina Kymie Vasques
Cavalcante, Bruno Raphael Ribeiro
Sousa, Ricardo Augusto Leoni de
Aras Júnior, Roque
Souza, Bruno Solano de Freitas
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Caria, Alex Cleber Improta
Nonaka, Carolina Kymie Vasques
Cavalcante, Bruno Raphael Ribeiro
Sousa, Ricardo Augusto Leoni de
Aras Júnior, Roque
Souza, Bruno Solano de Freitas
dc.subject.other.pt_BR.fl_str_mv Doença de Alzheimer
MicroRNAs
Exercício físico
topic Doença de Alzheimer
MicroRNAs
Exercício físico
Alzheimer disease
MicroRNAs
Physical exercise
dc.subject.en.pt_BR.fl_str_mv Alzheimer disease
MicroRNAs
Physical exercise
description Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–Brasil (CAPES)–Finance Code 001.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-01-28T16:08:00Z
dc.date.available.fl_str_mv 2021-01-28T16:08:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARIA, Alex Cleber Improta et al. Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease. International Journal of Molecular Sciences, v. 21, p. 1-35, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/45859
dc.identifier.issn.pt_BR.fl_str_mv 1661-6596
dc.identifier.doi.pt_BR.fl_str_mv 10.3390/ijms21144977
dc.identifier.eissn.none.fl_str_mv 10.3390/ijms21144977
identifier_str_mv CARIA, Alex Cleber Improta et al. Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease. International Journal of Molecular Sciences, v. 21, p. 1-35, 2020.
1661-6596
10.3390/ijms21144977
url https://www.arca.fiocruz.br/handle/icict/45859
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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