Human Helminth Co-Infection: Analysis of Spatial Patterns and Risk Factors in a Brazilian Community

Detalhes bibliográficos
Autor(a) principal: Pullan, Rachel L.
Data de Publicação: 2008
Outros Autores: Bethony, Jeffrey Michael, Geiger, Stefan Michael, Cundill, Bonnie, Oliveira, Rodrigo Corrêa de, Quinnell, Rupert J., Brooker, Simon
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/6676
Resumo: Human Hookworm Vaccine Initiative (HHVI) of the Sabin Vaccine Institute, Bill & Melinda Gates Foundation, Medical Research Council DTA-funded studentship and Career Development Fellowship (081673) from the Wellcome Trust.
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spelling Pullan, Rachel L.Bethony, Jeffrey MichaelGeiger, Stefan MichaelCundill, BonnieOliveira, Rodrigo Corrêa deQuinnell, Rupert J.Brooker, Simon2013-07-10T17:58:56Z2013-07-10T17:58:56Z2008PULLAN, Rachel L et al. Human Helminth Co-Infection: Analysis of Spatial Patterns and Risk Factors in a Brazilian Community. PLoS Negl Trop Dis. 2008, 2(12): e352.https://www.arca.fiocruz.br/handle/icict/667610.1371/journal.pntd.0000352Human Hookworm Vaccine Initiative (HHVI) of the Sabin Vaccine Institute, Bill & Melinda Gates Foundation, Medical Research Council DTA-funded studentship and Career Development Fellowship (081673) from the Wellcome Trust.London School of Hygiene and Tropical Medicine. London, United KingdomFundação Oswaldo Cruz. Rene Rachou Research Centre. Belo Horizonte, MG, Brazil/ The George Washington University. Washington D.C., United States of AmericaFundação Oswaldo Cruz. Rene Rachou Research Centre. Belo Horizonte, MG, Brazil/ The George Washington University. Washington D.C., United States of AmericaLondon School of Hygiene and Tropical Medicine. London, United KingdomFundação Oswaldo Cruz. Rene Rachou Research Centre. Belo Horizonte, MG, BrazilUniversity of Leeds. Leeds, United KingdomLondon School of Hygiene and Tropical Medicine. London, United KingdomBackground: Individuals living in areas endemic for helminths are commonly infected with multiple species. Despite increasing emphasis given to the potential health impacts of polyparasitism, few studies have investigated the relative importance of household and environmental factors on the risk of helminth co-infection. Here, we present an investigation of exposure-related risk factors as sources of heterogeneity in the distribution of co-infection with Necator americanus and Schistosoma mansoniin a region of southeastern Brazil. Methodology: Cross-sectional parasitological and socio-economic data from a community-based household survey were combined with remotely sensed environmental data using a geographical information system. Geo-statistical methods were used to explore patterns of mono- and co-infection with N. Americanus and S. mansoniin the region. Bayesian hierarchical models were then developed to identify risk factors for mono- and co-infection in relation to community-based survey data to assess their roles in explaining observed heterogeneity in mono and co-infection with these two helminth species. Principal Findings: The majority of individuals h ad N. americanus (71.1%) and/or S. mansoni(50.3%) infection; 41.0% of individuals were co-infected with both helminths. Prevalence of co-infection with these two species varied substantially across the study area, and there was strong evidence of household clustering. Hierarchical multinomial models demonstrated that relative socio-economic status, household crowding, living in the eastern watershed and high Normalized Difference Vegetation Index (NDVI) were significantly associated with N. americanus and S. mansonico-infection. These risk factors could, however, only account for an estimated 32% of variability between households. Conclusions: Our results demonstrate that variability in risk of N. americanus and S. mansoni co-infection between households cannot be entirely explained by exposure-related risk factors, emphasizing the possible role of other household factors in the heterogeneous distribution of helminth co-infection. Untangling the relative contribution of intrinsic host factors from household and environmental determinants therefore remains critical to our understanding of helminth epidemiology.engHuman Helminth Co-Infection: Analysis of Spatial Patterns and Risk Factors in a Brazilian Communityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehelmintiasisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL127. PULLAN RL,BETHONY JM.pdf127. PULLAN RL,BETHONY JM.pdfapplication/pdf242579https://www.arca.fiocruz.br/bitstream/icict/6676/1/127.%20PULLAN%20RL%2cBETHONY%20JM.pdf855a5d9ede1a84a2347578d2bdcf8b63MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/6676/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXT127. PULLAN RL,BETHONY JM.pdf.txt127. 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dc.title.pt_BR.fl_str_mv Human Helminth Co-Infection: Analysis of Spatial Patterns and Risk Factors in a Brazilian Community
title Human Helminth Co-Infection: Analysis of Spatial Patterns and Risk Factors in a Brazilian Community
spellingShingle Human Helminth Co-Infection: Analysis of Spatial Patterns and Risk Factors in a Brazilian Community
Pullan, Rachel L.
helmintiasis
title_short Human Helminth Co-Infection: Analysis of Spatial Patterns and Risk Factors in a Brazilian Community
title_full Human Helminth Co-Infection: Analysis of Spatial Patterns and Risk Factors in a Brazilian Community
title_fullStr Human Helminth Co-Infection: Analysis of Spatial Patterns and Risk Factors in a Brazilian Community
title_full_unstemmed Human Helminth Co-Infection: Analysis of Spatial Patterns and Risk Factors in a Brazilian Community
title_sort Human Helminth Co-Infection: Analysis of Spatial Patterns and Risk Factors in a Brazilian Community
author Pullan, Rachel L.
author_facet Pullan, Rachel L.
Bethony, Jeffrey Michael
Geiger, Stefan Michael
Cundill, Bonnie
Oliveira, Rodrigo Corrêa de
Quinnell, Rupert J.
Brooker, Simon
author_role author
author2 Bethony, Jeffrey Michael
Geiger, Stefan Michael
Cundill, Bonnie
Oliveira, Rodrigo Corrêa de
Quinnell, Rupert J.
Brooker, Simon
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pullan, Rachel L.
Bethony, Jeffrey Michael
Geiger, Stefan Michael
Cundill, Bonnie
Oliveira, Rodrigo Corrêa de
Quinnell, Rupert J.
Brooker, Simon
dc.subject.en.pt_BR.fl_str_mv helmintiasis
topic helmintiasis
description Human Hookworm Vaccine Initiative (HHVI) of the Sabin Vaccine Institute, Bill & Melinda Gates Foundation, Medical Research Council DTA-funded studentship and Career Development Fellowship (081673) from the Wellcome Trust.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2013-07-10T17:58:56Z
dc.date.available.fl_str_mv 2013-07-10T17:58:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv PULLAN, Rachel L et al. Human Helminth Co-Infection: Analysis of Spatial Patterns and Risk Factors in a Brazilian Community. PLoS Negl Trop Dis. 2008, 2(12): e352.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/6676
dc.identifier.doi.pt_BR.fl_str_mv 10.1371/journal.pntd.0000352
identifier_str_mv PULLAN, Rachel L et al. Human Helminth Co-Infection: Analysis of Spatial Patterns and Risk Factors in a Brazilian Community. PLoS Negl Trop Dis. 2008, 2(12): e352.
10.1371/journal.pntd.0000352
url https://www.arca.fiocruz.br/handle/icict/6676
dc.language.iso.fl_str_mv eng
language eng
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