Enhancement of the antibiotic activity mediated by the essential oil ofOcotea odorifera (VELL) ROWHER and safrole association
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50055 |
Resumo: | aLaboratório de Microbiologia e Biologia Molecular — LMBM, Universidade Regional do Cariri, Crato, CE, BrazilbGonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), BrazilcCentro Universitário Christus — Unichristus, Fortaleza, CE, BrazildFaculdade Maurício de Nassau — UNINASSAU, Petrolina, PE, BrazilePost Graduate Programme in Sustainable Territorial Development, Federal University of Paraná — UFPR, Matinhos, BrazilfPost Graduate Programme in Agronomy, Federal University of Paraná — UFPR, Curitiba, BrazilgFerdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand, IranhDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailanda |
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Almeida, Ray Silva deRibeiro Filho, JaimeFreitas, Priscilla RamosAraújo, Ana Carolina Justino deSantos, Eduardo Lourenço dosTintino, Saulo RelisonMoura, Talysson FelisminoFerreira, Vitória AssunçãoFerreira, Beatriz AssunçãoFonseca, Victor Juno AlencarLeite, Pedro Ivo PalacioSilva, Ana Cristina Albuquerque daSilva, Luiz Everson daAmaral, Wanderlei doDeschamps, CíceroSiyadatpanah, AbolghasemWilairatana, PolratCoutinho, Henrique Douglas MeloTintino, Saulo RelisonMoura, Talysson FelisminoFerreira, Vitória AssunçãoFerreira, Beatriz AssunçãoFonseca, Victor Juno AlencarLeite, Pedro Ivo PalacioSilva, Ana Cristina Albuquerque daSilva, Luiz Everson daAmaral, Wanderlei doDeschamps, CíceroSiyadatpanah, AbolghasemWilairatanah, PolratCoutinho, Henrique Douglas Melo2021-11-24T19:04:57Z2021-11-24T19:04:57Z2021ALMEIDA, Ray Silva de et al. Enhancement of the antibiotic activity mediated by the essential oil of Ocotea odorifera (VELL) ROWHER and safrole association. Journal of Infection and Public Health, 2021.1876-0341https://www.arca.fiocruz.br/handle/icict/5005510.1016/j.jiph.2021.09.028aLaboratório de Microbiologia e Biologia Molecular — LMBM, Universidade Regional do Cariri, Crato, CE, BrazilbGonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), BrazilcCentro Universitário Christus — Unichristus, Fortaleza, CE, BrazildFaculdade Maurício de Nassau — UNINASSAU, Petrolina, PE, BrazilePost Graduate Programme in Sustainable Territorial Development, Federal University of Paraná — UFPR, Matinhos, BrazilfPost Graduate Programme in Agronomy, Federal University of Paraná — UFPR, Curitiba, BrazilgFerdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand, IranhDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailanda"Múltipla ver em Notas"In a recent study, our research group demonstrated that the essential oil of Ocotea odorifera (EOOO)and its major compound safrole potentiated the action fluoroquinolones, modulating bacterial resistancepossibly due to direct inhibition of efflux pumps. Thus, in the present study, we investigated whether thesetreatments could enhance the activity of gentamicin and erythromycin against multidrug-resistant (MDR)bacteria. The EOOO was extracted by hydrodistillation, and the phytochemical analysis was performed bygas chromatography coupled to mass spectrometry (GC–MS). The antibiotic-enhancing effect of the EOOOand safrole against MDR strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa wasanalyzed by the broth microdilution method. The chemical analysis confirmed the presence of safrole as amajor component among the 16 compounds identified in the EOOO. Both the essential oil and the isolatedcompound showed clinically relevant antibacterial activities against S. aureus. Regarding the modulationof antibiotic resistance, the EOOO was found to enhance the activity of erythromycin against the strains ofP. aeruginosa and S. aureus, as well as improving the action of gentamicin against S. aureus. On the otherhand, safrole potentiated the activity of gentamicin against the S. aureus strain alone. It is concluded,therefore, that the EOOO and safrole can enhance the activity of macrolides and aminoglycosides, andas such are useful in the development of therapeutic tools to combat bacterial resistance against theseclasses of antibiotics.engElsevierMacrolídeosAminoglicosídeosRresistência aos antibióticosSafrolOcoteaMacrolidesAminoglycosidesAntibiotic resistance modulationSafroleOcotea odoriferaaEnhancement of the antibiotic activity mediated by the essential oil ofOcotea odorifera (VELL) ROWHER and safrole associationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/50055/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALAlmeida, Ray Silva de Enhancement....pdfAlmeida, Ray Silva de 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| dc.title.pt_BR.fl_str_mv |
Enhancement of the antibiotic activity mediated by the essential oil ofOcotea odorifera (VELL) ROWHER and safrole association |
| title |
Enhancement of the antibiotic activity mediated by the essential oil ofOcotea odorifera (VELL) ROWHER and safrole association |
| spellingShingle |
Enhancement of the antibiotic activity mediated by the essential oil ofOcotea odorifera (VELL) ROWHER and safrole association Almeida, Ray Silva de Macrolídeos Aminoglicosídeos Rresistência aos antibióticos Safrol Ocotea Macrolides Aminoglycosides Antibiotic resistance modulation Safrole Ocotea odoriferaa |
| title_short |
Enhancement of the antibiotic activity mediated by the essential oil ofOcotea odorifera (VELL) ROWHER and safrole association |
| title_full |
Enhancement of the antibiotic activity mediated by the essential oil ofOcotea odorifera (VELL) ROWHER and safrole association |
| title_fullStr |
Enhancement of the antibiotic activity mediated by the essential oil ofOcotea odorifera (VELL) ROWHER and safrole association |
| title_full_unstemmed |
Enhancement of the antibiotic activity mediated by the essential oil ofOcotea odorifera (VELL) ROWHER and safrole association |
| title_sort |
Enhancement of the antibiotic activity mediated by the essential oil ofOcotea odorifera (VELL) ROWHER and safrole association |
| author |
Almeida, Ray Silva de |
| author_facet |
Almeida, Ray Silva de Ribeiro Filho, Jaime Freitas, Priscilla Ramos Araújo, Ana Carolina Justino de Santos, Eduardo Lourenço dos Tintino, Saulo Relison Moura, Talysson Felismino Ferreira, Vitória Assunção Ferreira, Beatriz Assunção Fonseca, Victor Juno Alencar Leite, Pedro Ivo Palacio Silva, Ana Cristina Albuquerque da Silva, Luiz Everson da Amaral, Wanderlei do Deschamps, Cícero Siyadatpanah, Abolghasem Wilairatana, Polrat Coutinho, Henrique Douglas Melo Wilairatanah, Polrat |
| author_role |
author |
| author2 |
Ribeiro Filho, Jaime Freitas, Priscilla Ramos Araújo, Ana Carolina Justino de Santos, Eduardo Lourenço dos Tintino, Saulo Relison Moura, Talysson Felismino Ferreira, Vitória Assunção Ferreira, Beatriz Assunção Fonseca, Victor Juno Alencar Leite, Pedro Ivo Palacio Silva, Ana Cristina Albuquerque da Silva, Luiz Everson da Amaral, Wanderlei do Deschamps, Cícero Siyadatpanah, Abolghasem Wilairatana, Polrat Coutinho, Henrique Douglas Melo Wilairatanah, Polrat |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Almeida, Ray Silva de Ribeiro Filho, Jaime Freitas, Priscilla Ramos Araújo, Ana Carolina Justino de Santos, Eduardo Lourenço dos Tintino, Saulo Relison Moura, Talysson Felismino Ferreira, Vitória Assunção Ferreira, Beatriz Assunção Fonseca, Victor Juno Alencar Leite, Pedro Ivo Palacio Silva, Ana Cristina Albuquerque da Silva, Luiz Everson da Amaral, Wanderlei do Deschamps, Cícero Siyadatpanah, Abolghasem Wilairatana, Polrat Coutinho, Henrique Douglas Melo Tintino, Saulo Relison Moura, Talysson Felismino Ferreira, Vitória Assunção Ferreira, Beatriz Assunção Fonseca, Victor Juno Alencar Leite, Pedro Ivo Palacio Silva, Ana Cristina Albuquerque da Silva, Luiz Everson da Amaral, Wanderlei do Deschamps, Cícero Siyadatpanah, Abolghasem Wilairatanah, Polrat Coutinho, Henrique Douglas Melo |
| dc.subject.other.pt_BR.fl_str_mv |
Macrolídeos Aminoglicosídeos Rresistência aos antibióticos Safrol Ocotea |
| topic |
Macrolídeos Aminoglicosídeos Rresistência aos antibióticos Safrol Ocotea Macrolides Aminoglycosides Antibiotic resistance modulation Safrole Ocotea odoriferaa |
| dc.subject.en.pt_BR.fl_str_mv |
Macrolides Aminoglycosides Antibiotic resistance modulation Safrole Ocotea odoriferaa |
| description |
aLaboratório de Microbiologia e Biologia Molecular — LMBM, Universidade Regional do Cariri, Crato, CE, BrazilbGonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), BrazilcCentro Universitário Christus — Unichristus, Fortaleza, CE, BrazildFaculdade Maurício de Nassau — UNINASSAU, Petrolina, PE, BrazilePost Graduate Programme in Sustainable Territorial Development, Federal University of Paraná — UFPR, Matinhos, BrazilfPost Graduate Programme in Agronomy, Federal University of Paraná — UFPR, Curitiba, BrazilgFerdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand, IranhDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailanda |
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2021 |
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2021-11-24T19:04:57Z |
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2021-11-24T19:04:57Z |
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2021 |
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ALMEIDA, Ray Silva de et al. Enhancement of the antibiotic activity mediated by the essential oil of Ocotea odorifera (VELL) ROWHER and safrole association. Journal of Infection and Public Health, 2021. |
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https://www.arca.fiocruz.br/handle/icict/50055 |
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1876-0341 |
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10.1016/j.jiph.2021.09.028 |
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ALMEIDA, Ray Silva de et al. Enhancement of the antibiotic activity mediated by the essential oil of Ocotea odorifera (VELL) ROWHER and safrole association. Journal of Infection and Public Health, 2021. 1876-0341 10.1016/j.jiph.2021.09.028 |
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