An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/47472 |
Resumo: | Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil. |
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Ramos, Aline de SouzaFerreira, José Luiz PintoSilva, Jefferson Rocha de AndradeCruz, Jefferson D. daOliveira, Danielle L. deSilva, Maria Athana Mpalantinos daBasso, Silvia L.Amaral, Ana Claudia Fernandes2021-06-01T12:33:40Z2021-06-01T12:33:40Z2019RAMOS, Aline de Souza et al. An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis. Arabian Journal of Chemistry, v. 12, n. 4, p. 525-530, 2019.1878-5352https://www.arca.fiocruz.br/handle/icict/4747210.1016/j.arabjc.2017.05.002porElsevierAn experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Amazonas. Departamento de Química. Laboratório de Cromatografia. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil.Fundação de Tecnologia do Estado do Acre. Laboratório de Produtos Naturais. Rio Branco, AC, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil.The species of the genus Simaba (Simaroubaceae) are found in almost all Brazil and they are used by local population for the treatment of ulcers and malaria. The genus is characterized by the presence of quassinoids and canthinone alkaloids. There is a great interest in canthinones due to important biological activities associated with this class of alkaloids. In this study, methods were developed for obtaining enriched fractions of canthinone alkaloids from Simaba aff. paraensis using experimental factorial design analyzed by gas chromatography. Three alkaloids were detected: canthin-6-one, 4,5-dimethoxycanthin-6-one and the major 9-methoxycanthin-6-one. Within the experimental domain, factorial designs 22 helped establish the minimum amount of solvent and minimum time necessary to obtain extracts enriched in canthinone alkaloids from S. aff. paraensis barks by two extraction methods. These results represent a reduction in costs for obtaining canthinone alkaloids described for the first time in S. aff. paraensis.Medicinal Plantβ-Carboline AlkaloidsExtraction ProcessGC-MSinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83093https://www.arca.fiocruz.br/bitstream/icict/47472/1/license.txt34529d73b0c3f33b39c969c511d590fbMD51ORIGINAL1-s2.0-S1878535217300904-main.pdf1-s2.0-S1878535217300904-main.pdfapplication/pdf597664https://www.arca.fiocruz.br/bitstream/icict/47472/2/1-s2.0-S1878535217300904-main.pdf1c4ac5e01eb6ac22448e75dd69f24901MD52TEXT1-s2.0-S1878535217300904-main.pdf.txt1-s2.0-S1878535217300904-main.pdf.txtExtracted texttext/plain27770https://www.arca.fiocruz.br/bitstream/icict/47472/3/1-s2.0-S1878535217300904-main.pdf.txtee5fd43fe5dec6c073b470a3c1f9e252MD53icict/474722021-06-09 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dc.title.pt_BR.fl_str_mv |
An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis |
title |
An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis |
spellingShingle |
An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis Ramos, Aline de Souza Medicinal Plant β-Carboline Alkaloids Extraction Process GC-MS |
title_short |
An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis |
title_full |
An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis |
title_fullStr |
An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis |
title_full_unstemmed |
An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis |
title_sort |
An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis |
author |
Ramos, Aline de Souza |
author_facet |
Ramos, Aline de Souza Ferreira, José Luiz Pinto Silva, Jefferson Rocha de Andrade Cruz, Jefferson D. da Oliveira, Danielle L. de Silva, Maria Athana Mpalantinos da Basso, Silvia L. Amaral, Ana Claudia Fernandes |
author_role |
author |
author2 |
Ferreira, José Luiz Pinto Silva, Jefferson Rocha de Andrade Cruz, Jefferson D. da Oliveira, Danielle L. de Silva, Maria Athana Mpalantinos da Basso, Silvia L. Amaral, Ana Claudia Fernandes |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Ramos, Aline de Souza Ferreira, José Luiz Pinto Silva, Jefferson Rocha de Andrade Cruz, Jefferson D. da Oliveira, Danielle L. de Silva, Maria Athana Mpalantinos da Basso, Silvia L. Amaral, Ana Claudia Fernandes |
dc.subject.en.pt_BR.fl_str_mv |
Medicinal Plant β-Carboline Alkaloids Extraction Process GC-MS |
topic |
Medicinal Plant β-Carboline Alkaloids Extraction Process GC-MS |
description |
Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019 |
dc.date.accessioned.fl_str_mv |
2021-06-01T12:33:40Z |
dc.date.available.fl_str_mv |
2021-06-01T12:33:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
RAMOS, Aline de Souza et al. An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis. Arabian Journal of Chemistry, v. 12, n. 4, p. 525-530, 2019. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/47472 |
dc.identifier.issn.pt_BR.fl_str_mv |
1878-5352 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.arabjc.2017.05.002 |
identifier_str_mv |
RAMOS, Aline de Souza et al. An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis. Arabian Journal of Chemistry, v. 12, n. 4, p. 525-530, 2019. 1878-5352 10.1016/j.arabjc.2017.05.002 |
url |
https://www.arca.fiocruz.br/handle/icict/47472 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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