An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis

Detalhes bibliográficos
Autor(a) principal: Ramos, Aline de Souza
Data de Publicação: 2019
Outros Autores: Ferreira, José Luiz Pinto, Silva, Jefferson Rocha de Andrade, Cruz, Jefferson D. da, Oliveira, Danielle L. de, Silva, Maria Athana Mpalantinos da, Basso, Silvia L., Amaral, Ana Claudia Fernandes
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/47472
Resumo: Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil.
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spelling Ramos, Aline de SouzaFerreira, José Luiz PintoSilva, Jefferson Rocha de AndradeCruz, Jefferson D. daOliveira, Danielle L. deSilva, Maria Athana Mpalantinos daBasso, Silvia L.Amaral, Ana Claudia Fernandes2021-06-01T12:33:40Z2021-06-01T12:33:40Z2019RAMOS, Aline de Souza et al. An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis. Arabian Journal of Chemistry, v. 12, n. 4, p. 525-530, 2019.1878-5352https://www.arca.fiocruz.br/handle/icict/4747210.1016/j.arabjc.2017.05.002porElsevierAn experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Amazonas. Departamento de Química. Laboratório de Cromatografia. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil.Fundação de Tecnologia do Estado do Acre. Laboratório de Produtos Naturais. Rio Branco, AC, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil.The species of the genus Simaba (Simaroubaceae) are found in almost all Brazil and they are used by local population for the treatment of ulcers and malaria. The genus is characterized by the presence of quassinoids and canthinone alkaloids. There is a great interest in canthinones due to important biological activities associated with this class of alkaloids. In this study, methods were developed for obtaining enriched fractions of canthinone alkaloids from Simaba aff. paraensis using experimental factorial design analyzed by gas chromatography. Three alkaloids were detected: canthin-6-one, 4,5-dimethoxycanthin-6-one and the major 9-methoxycanthin-6-one. Within the experimental domain, factorial designs 22 helped establish the minimum amount of solvent and minimum time necessary to obtain extracts enriched in canthinone alkaloids from S. aff. paraensis barks by two extraction methods. These results represent a reduction in costs for obtaining canthinone alkaloids described for the first time in S. aff. paraensis.Medicinal Plantβ-Carboline AlkaloidsExtraction ProcessGC-MSinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83093https://www.arca.fiocruz.br/bitstream/icict/47472/1/license.txt34529d73b0c3f33b39c969c511d590fbMD51ORIGINAL1-s2.0-S1878535217300904-main.pdf1-s2.0-S1878535217300904-main.pdfapplication/pdf597664https://www.arca.fiocruz.br/bitstream/icict/47472/2/1-s2.0-S1878535217300904-main.pdf1c4ac5e01eb6ac22448e75dd69f24901MD52TEXT1-s2.0-S1878535217300904-main.pdf.txt1-s2.0-S1878535217300904-main.pdf.txtExtracted texttext/plain27770https://www.arca.fiocruz.br/bitstream/icict/47472/3/1-s2.0-S1878535217300904-main.pdf.txtee5fd43fe5dec6c073b470a3c1f9e252MD53icict/474722021-06-09 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dc.title.pt_BR.fl_str_mv An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis
title An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis
spellingShingle An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis
Ramos, Aline de Souza
Medicinal Plant
β-Carboline Alkaloids
Extraction Process
GC-MS
title_short An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis
title_full An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis
title_fullStr An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis
title_full_unstemmed An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis
title_sort An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis
author Ramos, Aline de Souza
author_facet Ramos, Aline de Souza
Ferreira, José Luiz Pinto
Silva, Jefferson Rocha de Andrade
Cruz, Jefferson D. da
Oliveira, Danielle L. de
Silva, Maria Athana Mpalantinos da
Basso, Silvia L.
Amaral, Ana Claudia Fernandes
author_role author
author2 Ferreira, José Luiz Pinto
Silva, Jefferson Rocha de Andrade
Cruz, Jefferson D. da
Oliveira, Danielle L. de
Silva, Maria Athana Mpalantinos da
Basso, Silvia L.
Amaral, Ana Claudia Fernandes
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ramos, Aline de Souza
Ferreira, José Luiz Pinto
Silva, Jefferson Rocha de Andrade
Cruz, Jefferson D. da
Oliveira, Danielle L. de
Silva, Maria Athana Mpalantinos da
Basso, Silvia L.
Amaral, Ana Claudia Fernandes
dc.subject.en.pt_BR.fl_str_mv Medicinal Plant
β-Carboline Alkaloids
Extraction Process
GC-MS
topic Medicinal Plant
β-Carboline Alkaloids
Extraction Process
GC-MS
description Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2021-06-01T12:33:40Z
dc.date.available.fl_str_mv 2021-06-01T12:33:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RAMOS, Aline de Souza et al. An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis. Arabian Journal of Chemistry, v. 12, n. 4, p. 525-530, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/47472
dc.identifier.issn.pt_BR.fl_str_mv 1878-5352
dc.identifier.doi.none.fl_str_mv 10.1016/j.arabjc.2017.05.002
identifier_str_mv RAMOS, Aline de Souza et al. An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis. Arabian Journal of Chemistry, v. 12, n. 4, p. 525-530, 2019.
1878-5352
10.1016/j.arabjc.2017.05.002
url https://www.arca.fiocruz.br/handle/icict/47472
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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