Mitochondrial genome instability in colorectal adenoma and adenocarcinoma

Detalhes bibliográficos
Autor(a) principal: Araujo, Luiza Ferreira de
Data de Publicação: 2015
Outros Autores: Fonseca, Aline Simonete, Muys, Bruna Rodrigues, Plaça, Jessica Rodrigues, Bueno, Rafaela de Barros e Lima, Lorenzi, Julio Cesar Cetrulo, Santos, Anemari Ramos Dinarte dos, Molfetta, Greice Andreotti de, Zanette, Dalila Lucíola, Souza, Jorge Estefano Santana de, Valente, Valeria, Silva Junior, Wilson Araujo da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20949
Resumo: Zanette, Dalila Lucíola “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Araujo, Luiza Ferreira deFonseca, Aline SimoneteMuys, Bruna RodriguesPlaça, Jessica RodriguesBueno, Rafaela de Barros e LimaLorenzi, Julio Cesar CetruloSantos, Anemari Ramos Dinarte dosMolfetta, Greice Andreotti deZanette, Dalila LucíolaSouza, Jorge Estefano Santana deValente, ValeriaSilva Junior, Wilson Araujo da2017-09-11T19:41:06Z2017-09-11T19:41:06Z2015ARAUJO, L. F. et al. Mitochondrial genome instability in colorectal adenoma and adenocarcinoma. Tumor Biology, v. 36, n. 11, p. 8869-8879, 2015.1010-4283https://www.arca.fiocruz.br/handle/icict/2094910.1007/s13277-015-3640-7Zanette, Dalila Lucíola “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.The National Council for Scientific and Technological Development (CNPq), grant #573754/2008-0; by grants #2008/57877-3 and #2013/08135-2, São Paulo Research Foundation (FAPESP); and by Research Support of the University Sao Paulo, CISBi-NAP/USP #12.1.25441.01.2.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, BrazilCenter for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, BrazilCenter for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, Brazil / Center for Medical Genomics. Center for Integrative Systems Biology. Ribeirão Preto, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, Brazil / Center for Medical Genomics. Center for Integrative Systems Biology. Ribeirão Preto, SP, BrazilCenter for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, Brazil / Center for Medical Genomics. Center for Integrative Systems Biology. Ribeirão Preto, SP, BrazilCenter for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, Brazil / Center for Medical Genomics. Center for Integrative Systems Biology. Ribeirão Preto, SP, Brazil / University of São Paulo State. Faculty of Pharmaceutical Science of Araraquara. Department of Clinical Analysis. Araraquara, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / Center for Cell-Based. Therapy Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem cell and Cell Therapy. Ribeirão Preto, SP, Brazil / Center for Medical Genomics. Center for Integrative Systems Biology. Ribeirão Preto, SP, BrazilMitochondrial dysfunction is regarded as a hallmark of cancer progression. In the current study, we evaluated mitochondrial genome instability and copy number in colorectal cancer using Next Generation Sequencing approach and qPCR, respectively. The results revealed higher levels of heteroplasmy and depletion of the relative mtDNA copy number in colorectal adenocarcinoma. Adenocarcinoma samples also presented an increased number of mutations in nuclear genes encoding proteins which functions are related with mitochondria fusion, fission and localization. Moreover, we found a set of mitochondrial and nuclear genes, which cooperate in the same mitochondrial function simultaneously mutated in adenocarcinoma. In summary, these results support an important role for mitochondrial function and genomic instability in colorectal tumorigenesis.engSpringer VerlagGenoma mitocondrialCâncer colorretalHeteroplasmiaInstabilidade do genomaMitochondrial genomeColorectal cancerHeteroplasmyGenome instabilityMitochondrial genome instability in colorectal adenoma and adenocarcinomainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20949/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAraujo LF Mitochondrial genome....pdfAraujo LF Mitochondrial genome....pdfapplication/pdf1180653https://www.arca.fiocruz.br/bitstream/icict/20949/2/Araujo%20LF%20Mitochondrial%20genome....pdf46ae00e6b7e596048911d407b473eb6aMD52TEXTAraujo LF Mitochondrial 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dc.title.pt_BR.fl_str_mv Mitochondrial genome instability in colorectal adenoma and adenocarcinoma
title Mitochondrial genome instability in colorectal adenoma and adenocarcinoma
spellingShingle Mitochondrial genome instability in colorectal adenoma and adenocarcinoma
Araujo, Luiza Ferreira de
Genoma mitocondrial
Câncer colorretal
Heteroplasmia
Instabilidade do genoma
Mitochondrial genome
Colorectal cancer
Heteroplasmy
Genome instability
title_short Mitochondrial genome instability in colorectal adenoma and adenocarcinoma
title_full Mitochondrial genome instability in colorectal adenoma and adenocarcinoma
title_fullStr Mitochondrial genome instability in colorectal adenoma and adenocarcinoma
title_full_unstemmed Mitochondrial genome instability in colorectal adenoma and adenocarcinoma
title_sort Mitochondrial genome instability in colorectal adenoma and adenocarcinoma
author Araujo, Luiza Ferreira de
author_facet Araujo, Luiza Ferreira de
Fonseca, Aline Simonete
Muys, Bruna Rodrigues
Plaça, Jessica Rodrigues
Bueno, Rafaela de Barros e Lima
Lorenzi, Julio Cesar Cetrulo
Santos, Anemari Ramos Dinarte dos
Molfetta, Greice Andreotti de
Zanette, Dalila Lucíola
Souza, Jorge Estefano Santana de
Valente, Valeria
Silva Junior, Wilson Araujo da
author_role author
author2 Fonseca, Aline Simonete
Muys, Bruna Rodrigues
Plaça, Jessica Rodrigues
Bueno, Rafaela de Barros e Lima
Lorenzi, Julio Cesar Cetrulo
Santos, Anemari Ramos Dinarte dos
Molfetta, Greice Andreotti de
Zanette, Dalila Lucíola
Souza, Jorge Estefano Santana de
Valente, Valeria
Silva Junior, Wilson Araujo da
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Araujo, Luiza Ferreira de
Fonseca, Aline Simonete
Muys, Bruna Rodrigues
Plaça, Jessica Rodrigues
Bueno, Rafaela de Barros e Lima
Lorenzi, Julio Cesar Cetrulo
Santos, Anemari Ramos Dinarte dos
Molfetta, Greice Andreotti de
Zanette, Dalila Lucíola
Souza, Jorge Estefano Santana de
Valente, Valeria
Silva Junior, Wilson Araujo da
dc.subject.other.pt_BR.fl_str_mv Genoma mitocondrial
Câncer colorretal
Heteroplasmia
Instabilidade do genoma
topic Genoma mitocondrial
Câncer colorretal
Heteroplasmia
Instabilidade do genoma
Mitochondrial genome
Colorectal cancer
Heteroplasmy
Genome instability
dc.subject.en.pt_BR.fl_str_mv Mitochondrial genome
Colorectal cancer
Heteroplasmy
Genome instability
description Zanette, Dalila Lucíola “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2017-09-11T19:41:06Z
dc.date.available.fl_str_mv 2017-09-11T19:41:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ARAUJO, L. F. et al. Mitochondrial genome instability in colorectal adenoma and adenocarcinoma. Tumor Biology, v. 36, n. 11, p. 8869-8879, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20949
dc.identifier.issn.pt_BR.fl_str_mv 1010-4283
dc.identifier.doi.none.fl_str_mv 10.1007/s13277-015-3640-7
identifier_str_mv ARAUJO, L. F. et al. Mitochondrial genome instability in colorectal adenoma and adenocarcinoma. Tumor Biology, v. 36, n. 11, p. 8869-8879, 2015.
1010-4283
10.1007/s13277-015-3640-7
url https://www.arca.fiocruz.br/handle/icict/20949
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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