Long-term treatment of NZB mice with anti-CD4 results in wasting disease, lymphoid atrophy and chronic diarrhea

• Autor(a) principal: Oliveira, Geraldo Gileno de Sá
• Data de Publicação: 2010
• Outros Autores: Holton, John, Lydyard, Peter M
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
• Texto Completo: https://www.arca.fiocruz.br/handle/icict/1751
• topic: Diareia cronica; Anti-CD4; Modelo animal; Camundongos NZB; anti-CD4; Chronic Diarrhea; Animal model; NZB mice; Helical bacteria; Antígenos CD4; Diarreia; Escherichia coli; Camundongos Endogâmicos NZB; Modelos animais

In this paper, we have shown that long-term treatment of NZB mice with anti-CD4 antibody results in four major pathological effects: firstly the development of a severe wasting disease; secondly lymphoid atrophy of the thymus, spleen, mesenteric lymph node and Peyers patches (PP); thirdly, severe chronic ulcerative colitis and fourthly a neutrophilia with neutrophil infiltration in the spleen, liver and mesenteric lymph nodes. At the same time, mice subjected to anti-CD4 treatment showed a reduction in the microbial diversity in ileal walls and contents, as well as in colonic contents, together with overgrowth of E. coli in the intestinal lumen and wall. In addition, there was the appearance of large numbers of spiral shaped bacteria on the mucosal surface often associated with colonic ulceration.