Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant.

Detalhes bibliográficos
Autor(a) principal: Campos, Guilherme R F
Data de Publicação: 2022
Outros Autores: Almeida, Nathalie Bonatti Franco, Filgueiras, Priscilla Soares, Corsini, Camila Amormino, Gomes, Sarah Vieira Contin, Miranda, Daniel Alvim Pena de, Assis, Jéssica Vieira de, Silva, Thaís Bárbara de Souza, Alves, Pedro Augusto, Fernandes, Gabriel da Rocha, Oliveira, Jaquelline Germano de, Rahal, Paula, Grenfell, Rafaella Fortini Queiroz, Nogueira, Maurício L
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56478
Resumo: Faculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisas em Virologia. São José do Rio Preto, SP, Brazil.
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spelling Campos, Guilherme R FAlmeida, Nathalie Bonatti FrancoFilgueiras, Priscilla SoaresCorsini, Camila AmorminoGomes, Sarah Vieira ContinMiranda, Daniel Alvim Pena deAssis, Jéssica Vieira deSilva, Thaís Bárbara de SouzaAlves, Pedro AugustoFernandes, Gabriel da RochaOliveira, Jaquelline Germano deRahal, PaulaGrenfell, Rafaella Fortini QueirozNogueira, Maurício L2023-01-16T19:19:41Z2023-01-16T19:19:41Z2022CAMPOS, Guilherme R F et al. Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant. Commun Med,. V. 2, 76, 2022. doi: 10.1038/s43856-022-00141-4.2730-664Xhttps://www.arca.fiocruz.br/handle/icict/56478engNature PortfolioBooster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFaculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisas em Virologia. São José do Rio Preto, SP, Brazil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Diagnóstico e Terapia de Doenças Infeccionas e Câncer. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Diagnóstico e Terapia de Doenças Infeccionas e Câncer. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Diagnóstico e Terapia de Doenças Infeccionas e Câncer. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Diagnóstico e Terapia de Doenças Infeccionas e Câncer. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Diagnóstico e Terapia de Doenças Infeccionas e Câncer. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Diagnóstico e Terapia de Doenças Infeccionas e Câncer. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Imunologia de Doenças Virais. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Imunologia de Doenças Virais. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Diagnóstico e Terapia de Doenças Infeccionas e Câncer. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil.Universidade Estadual Paulista. Instituto de Biociências Letras e Ciências Exatas. Departamento de Biologia. Laboratório de Estudos Genômicos. São José do Rio Preto, SP, Brazil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Diagnóstico e Terapia de Doenças Infeccionas e Câncer. Belo Horizonte, MG, Brazil/ Department of Infectious Diseases. College of Veterinary Medicine. University of Georgia. Athens, GA USA.Faculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisas em Virologia. São José do Rio Preto, SP, Brazil/Hospital de Base. São José do Rio Preto, SP, Brazil/Department of Pathology. University of Texas Medical Branch. Galveston, TX USA.Background: The emergence of the new SARS-CoV-2 Omicron variant, which is known to have a large number of mutations when compared to other variants, brought to light the concern about vaccine escape, especially from the neutralization by antibodies induced by vaccination. Methods: Based on viral microneutralization assays, we evaluated in 90 individuals the impact on antibody neutralization induction, against Omicron variant, by a booster dose of BNT162b2 mRNA vaccine after the CoronaVac primary vaccination scheme. Results: Here we show that the percentage of seroconverted individuals 30 and 60 days after CoronaVac scheme was 16.6% and 10%, respectively. After booster dose administration, the seroconvertion rate increased to 76.6%. The neutralization mean titer against Omicron in the CoronaVac protocol decreased over time, but after the booster dose, the mean titer increased 43.1 times. Conclusions: These results indicate a positive impact of this vaccine combination in the serological immune response against SARS-CoV-2 Omicron variant.Viral infectionVirologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56478/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBooster dose of BNT162b2 after two doses.pdfBooster dose of BNT162b2 after two doses.pdfapplication/pdf188064https://www.arca.fiocruz.br/bitstream/icict/56478/2/Booster%20dose%20of%20BNT162b2%20after%20two%20doses.pdf9decff113a5a83513c12bd91530b8b86MD52icict/564782023-01-16 16:19:42.653oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-01-16T19:19:42Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.en_US.fl_str_mv Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant.
title Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant.
spellingShingle Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant.
Campos, Guilherme R F
Viral infection
Virology
title_short Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant.
title_full Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant.
title_fullStr Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant.
title_full_unstemmed Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant.
title_sort Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant.
author Campos, Guilherme R F
author_facet Campos, Guilherme R F
Almeida, Nathalie Bonatti Franco
Filgueiras, Priscilla Soares
Corsini, Camila Amormino
Gomes, Sarah Vieira Contin
Miranda, Daniel Alvim Pena de
Assis, Jéssica Vieira de
Silva, Thaís Bárbara de Souza
Alves, Pedro Augusto
Fernandes, Gabriel da Rocha
Oliveira, Jaquelline Germano de
Rahal, Paula
Grenfell, Rafaella Fortini Queiroz
Nogueira, Maurício L
author_role author
author2 Almeida, Nathalie Bonatti Franco
Filgueiras, Priscilla Soares
Corsini, Camila Amormino
Gomes, Sarah Vieira Contin
Miranda, Daniel Alvim Pena de
Assis, Jéssica Vieira de
Silva, Thaís Bárbara de Souza
Alves, Pedro Augusto
Fernandes, Gabriel da Rocha
Oliveira, Jaquelline Germano de
Rahal, Paula
Grenfell, Rafaella Fortini Queiroz
Nogueira, Maurício L
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Campos, Guilherme R F
Almeida, Nathalie Bonatti Franco
Filgueiras, Priscilla Soares
Corsini, Camila Amormino
Gomes, Sarah Vieira Contin
Miranda, Daniel Alvim Pena de
Assis, Jéssica Vieira de
Silva, Thaís Bárbara de Souza
Alves, Pedro Augusto
Fernandes, Gabriel da Rocha
Oliveira, Jaquelline Germano de
Rahal, Paula
Grenfell, Rafaella Fortini Queiroz
Nogueira, Maurício L
dc.subject.en.en_US.fl_str_mv Viral infection
Virology
topic Viral infection
Virology
description Faculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisas em Virologia. São José do Rio Preto, SP, Brazil.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-01-16T19:19:41Z
dc.date.available.fl_str_mv 2023-01-16T19:19:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CAMPOS, Guilherme R F et al. Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant. Commun Med,. V. 2, 76, 2022. doi: 10.1038/s43856-022-00141-4.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56478
dc.identifier.issn.en_US.fl_str_mv 2730-664X
identifier_str_mv CAMPOS, Guilherme R F et al. Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant. Commun Med,. V. 2, 76, 2022. doi: 10.1038/s43856-022-00141-4.
2730-664X
url https://www.arca.fiocruz.br/handle/icict/56478
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Portfolio
publisher.none.fl_str_mv Nature Portfolio
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56478/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/56478/2/Booster%20dose%20of%20BNT162b2%20after%20two%20doses.pdf
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