Therapy for ocular toxoplasmosis

Detalhes bibliográficos
Autor(a) principal: De-La-Torre, Alejandra
Data de Publicação: 2011
Outros Autores: Stanford, Miles, Curi, André, Jaffe, Glenn J., Gomez-Marin, Jorge E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37117
Resumo: 2020-11-18
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spelling De-La-Torre, AlejandraStanford, MilesCuri, AndréJaffe, Glenn J.Gomez-Marin, Jorge E.2019-11-18T14:34:02Z2019-11-18T14:34:02Z2011DE-LA-TORRE, Alejandra et al. Therapy for ocular toxoplasmosis. Ocular Immunology and Inflammation, v. 19, n. 5, p. 314-320, 2011.0927-3948https://www.arca.fiocruz.br/handle/icict/3711710.3109/09273948.2011.6089151678-8060engTaylor & FrancisTherapy for ocular toxoplasmosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-11-18Universidad del Quindío. Centro de Investigaciones Biomédicas. Grupo de Estudio en Parasitología Molecular. Armenia, Colombia.King’s College London. St. Thomas’ Campus. Rayne Institute, Department of Academic Ophthalmology. London, UK.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Duke Eye Center. Duke Reading Center. Durham, NC, USA.Universidad del Quindío. Centro de Investigaciones Biomédicas. Grupo de Estudio en Parasitología Molecular. Armenia, Colombia.Purpose: To review current evidence for the treatment of ocular toxoplasmosis (OT). Design: Narrative review and expert recommendations. Methods: Meta-analysis and selected original articles from the medical literature were reviewed critically. Expert recommendations were analyzed. Results: Numerous observational studies suggest a benefit of short-term antimicrobial therapy for toxoplasmic retinochoroiditis in immunocompetent patients, although its efficacy has not been proven in randomized clinical trials. A randomized clinical trial revealed that intermittent trimethoprim/sulfamethoxazole treatment could decrease the rate of recurrence in high-risk patients. Intravitreal injection of clindamycin and dexamethasone was an acceptable alternative to the classic treatment for OT in a randomized clinical trial. Conclusions: Opinions about therapy differ and controversy remains about its type, efficacy, and length. Intravitreal therapy may be promising for OT. A recent description of the presence of parasitemia in patients with active and inactive ocular toxoplasmosis raises new questions that need to be explored.AntibioticsOcular toxoplasmosisRecurrencesSteroidsTherapyTreatmentUveitisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/37117/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_De-La-Torre_Alejandra_etal INI_2011.pdfve_De-La-Torre_Alejandra_etal INI_2011.pdfapplication/pdf716556https://www.arca.fiocruz.br/bitstream/icict/37117/2/ve_De-La-Torre_Alejandra_etal%20INI_2011.pdf40401d3c7d7f66a2073c0c510bb6f1b8MD52TEXTve_De-La-Torre_Alejandra_etal INI_2011.pdf.txtve_De-La-Torre_Alejandra_etal INI_2011.pdf.txtExtracted texttext/plain39596https://www.arca.fiocruz.br/bitstream/icict/37117/3/ve_De-La-Torre_Alejandra_etal%20INI_2011.pdf.txtbaacd3fc93a659385f619fbb755701fdMD53icict/371172021-03-24 16:32:39.363oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:39Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Therapy for ocular toxoplasmosis
title Therapy for ocular toxoplasmosis
spellingShingle Therapy for ocular toxoplasmosis
De-La-Torre, Alejandra
Antibiotics
Ocular toxoplasmosis
Recurrences
Steroids
Therapy
Treatment
Uveitis
title_short Therapy for ocular toxoplasmosis
title_full Therapy for ocular toxoplasmosis
title_fullStr Therapy for ocular toxoplasmosis
title_full_unstemmed Therapy for ocular toxoplasmosis
title_sort Therapy for ocular toxoplasmosis
author De-La-Torre, Alejandra
author_facet De-La-Torre, Alejandra
Stanford, Miles
Curi, André
Jaffe, Glenn J.
Gomez-Marin, Jorge E.
author_role author
author2 Stanford, Miles
Curi, André
Jaffe, Glenn J.
Gomez-Marin, Jorge E.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv De-La-Torre, Alejandra
Stanford, Miles
Curi, André
Jaffe, Glenn J.
Gomez-Marin, Jorge E.
dc.subject.en.pt_BR.fl_str_mv Antibiotics
Ocular toxoplasmosis
Recurrences
Steroids
Therapy
Treatment
Uveitis
topic Antibiotics
Ocular toxoplasmosis
Recurrences
Steroids
Therapy
Treatment
Uveitis
description 2020-11-18
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2019-11-18T14:34:02Z
dc.date.available.fl_str_mv 2019-11-18T14:34:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DE-LA-TORRE, Alejandra et al. Therapy for ocular toxoplasmosis. Ocular Immunology and Inflammation, v. 19, n. 5, p. 314-320, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37117
dc.identifier.issn.pt_BR.fl_str_mv 0927-3948
dc.identifier.doi.none.fl_str_mv 10.3109/09273948.2011.608915
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv DE-LA-TORRE, Alejandra et al. Therapy for ocular toxoplasmosis. Ocular Immunology and Inflammation, v. 19, n. 5, p. 314-320, 2011.
0927-3948
10.3109/09273948.2011.608915
1678-8060
url https://www.arca.fiocruz.br/handle/icict/37117
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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