Prevalence of HIV type 1 drug resistance mutations in treatment-naïve and experienced patients from resource-limited settings with universal access to antiretroviral therapy: a survey in two small Brazilian cities

Detalhes bibliográficos
Autor(a) principal: Silva, Walter A. Eyer
Data de Publicação: 2008
Outros Autores: Fernandez, José Carlos Couto, Jesus, Carlos Silva de, Morgado, Mariza G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27307
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil / Hospital Universitário Gaffreé Guinle. Rio de Janeiro, RJ, Brasil / Programa Muniicipal de HIV-Aids de Saquarema,. Saquarema, RJ, Brasil / Programa Municipal de HIV-1/Aids de Santo Antonio de Pádua. Santo Antonio de Pádua, RJ, Brasil.
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spelling Silva, Walter A. EyerFernandez, José Carlos CoutoJesus, Carlos Silva deMorgado, Mariza G.2018-07-05T13:45:12Z2018-07-05T13:45:12Z2008SILVA, Walter A. Eyer; et al. Prevalence of HIV type 1 drug resistance mutations in treatment-naïve and experienced patients from resource-limited settings with universal access to antiretroviral therapy: a survey in two small Brazilian cities. Mem Inst Oswaldo Cruz, v.103, n.2, p.143-149, Mar. 2008.0074-0276https://www.arca.fiocruz.br/handle/icict/273071678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzTerapia anti-retroviralvírus da imunodeficiência humana tipo 1resistênciaBrasilantiretroviral therapyBrazilhuman immunodeficiency virus type 1resistancePrevalence of HIV type 1 drug resistance mutations in treatment-naïve and experienced patients from resource-limited settings with universal access to antiretroviral therapy: a survey in two small Brazilian citiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil / Hospital Universitário Gaffreé Guinle. Rio de Janeiro, RJ, Brasil / Programa Muniicipal de HIV-Aids de Saquarema,. Saquarema, RJ, Brasil / Programa Municipal de HIV-1/Aids de Santo Antonio de Pádua. Santo Antonio de Pádua, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil / Hospital Universitário Gaffreé Guinle. Rio de Janeiro, RJ, Brasil / Programa Muniicipal de HIV-Aids de Saquarema,. Saquarema, RJ, Brasil / Programa Municipal de HIV-1/Aids de Santo Antonio de Pádua. Santo Antonio de Pádua, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil / Hospital Universitário Gaffreé Guinle. Rio de Janeiro, RJ, Brasil / Programa Muniicipal de HIV-Aids de Saquarema,. Saquarema, RJ, Brasil / Programa Municipal de HIV-1/Aids de Santo Antonio de Pádua. Santo Antonio de Pádua, RJ, Brasil.Concerns have been raised that universal availability of antiretroviral agents in resource-limited settings might lead to the emergence and spread of resistant strains. We present the largest survey on human immunodeficiency virus type 1 (HIV-1) resistance among treatment-naïve and experienced patients followed in small, relatively underprivileged cities in Brazil with universal availability to standard of care antiretroviral combinations. Samples were collected between 2004 and 2006 from 95 patients followed in the cities of Saquarema and Santo Antonio de Pádua, state of Rio de Janeiro. A proviral fragment encompassing protease and reverse transcriptase (RT) regions was generated and drug susceptibility level was inferred. Among 50 strains from drug-naïve subjects, one (2%) had intermediate-level resistance to RT inhibitors. Among 38 patients on therapy as of sampling, 28 (73.7%) had plasma viral load (PVL) below detection limit (26 of whom without evidence of resistance mutations) and 11 (28.9%) harbored strains with reduced susceptibility. Only two strains harbored both protease and RT inhibitor mutations. Among seven patients who were off-treatment as of sampling, two (28.5%) harbored strains with reduced susceptibility to RT inhibitors. The relatively high frequency of undetectable PVL among patients on treatment and the overall low prevalence of resistance-associated mutations are reassuring. Continued surveillance, however, is necessary.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27307/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALwalter_silva_etal_IOC_2008.pdfwalter_silva_etal_IOC_2008.pdfapplication/pdf318080https://www.arca.fiocruz.br/bitstream/icict/27307/2/walter_silva_etal_IOC_2008.pdf94c1dfb901e196d08d686954bc8469c6MD52TEXTwalter_silva_etal_IOC_2008.pdf.txtwalter_silva_etal_IOC_2008.pdf.txtExtracted texttext/plain36486https://www.arca.fiocruz.br/bitstream/icict/27307/3/walter_silva_etal_IOC_2008.pdf.txt7691c3e23c446adb5003d98711c9c64aMD53icict/273072018-08-15 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dc.title.pt_BR.fl_str_mv Prevalence of HIV type 1 drug resistance mutations in treatment-naïve and experienced patients from resource-limited settings with universal access to antiretroviral therapy: a survey in two small Brazilian cities
title Prevalence of HIV type 1 drug resistance mutations in treatment-naïve and experienced patients from resource-limited settings with universal access to antiretroviral therapy: a survey in two small Brazilian cities
spellingShingle Prevalence of HIV type 1 drug resistance mutations in treatment-naïve and experienced patients from resource-limited settings with universal access to antiretroviral therapy: a survey in two small Brazilian cities
Silva, Walter A. Eyer
Terapia anti-retroviral
vírus da imunodeficiência humana tipo 1
resistência
Brasil
antiretroviral therapy
Brazil
human immunodeficiency virus type 1
resistance
title_short Prevalence of HIV type 1 drug resistance mutations in treatment-naïve and experienced patients from resource-limited settings with universal access to antiretroviral therapy: a survey in two small Brazilian cities
title_full Prevalence of HIV type 1 drug resistance mutations in treatment-naïve and experienced patients from resource-limited settings with universal access to antiretroviral therapy: a survey in two small Brazilian cities
title_fullStr Prevalence of HIV type 1 drug resistance mutations in treatment-naïve and experienced patients from resource-limited settings with universal access to antiretroviral therapy: a survey in two small Brazilian cities
title_full_unstemmed Prevalence of HIV type 1 drug resistance mutations in treatment-naïve and experienced patients from resource-limited settings with universal access to antiretroviral therapy: a survey in two small Brazilian cities
title_sort Prevalence of HIV type 1 drug resistance mutations in treatment-naïve and experienced patients from resource-limited settings with universal access to antiretroviral therapy: a survey in two small Brazilian cities
author Silva, Walter A. Eyer
author_facet Silva, Walter A. Eyer
Fernandez, José Carlos Couto
Jesus, Carlos Silva de
Morgado, Mariza G.
author_role author
author2 Fernandez, José Carlos Couto
Jesus, Carlos Silva de
Morgado, Mariza G.
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva, Walter A. Eyer
Fernandez, José Carlos Couto
Jesus, Carlos Silva de
Morgado, Mariza G.
dc.subject.other.pt_BR.fl_str_mv Terapia anti-retroviral
vírus da imunodeficiência humana tipo 1
resistência
Brasil
topic Terapia anti-retroviral
vírus da imunodeficiência humana tipo 1
resistência
Brasil
antiretroviral therapy
Brazil
human immunodeficiency virus type 1
resistance
dc.subject.en.pt_BR.fl_str_mv antiretroviral therapy
Brazil
human immunodeficiency virus type 1
resistance
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil / Hospital Universitário Gaffreé Guinle. Rio de Janeiro, RJ, Brasil / Programa Muniicipal de HIV-Aids de Saquarema,. Saquarema, RJ, Brasil / Programa Municipal de HIV-1/Aids de Santo Antonio de Pádua. Santo Antonio de Pádua, RJ, Brasil.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2018-07-05T13:45:12Z
dc.date.available.fl_str_mv 2018-07-05T13:45:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Walter A. Eyer; et al. Prevalence of HIV type 1 drug resistance mutations in treatment-naïve and experienced patients from resource-limited settings with universal access to antiretroviral therapy: a survey in two small Brazilian cities. Mem Inst Oswaldo Cruz, v.103, n.2, p.143-149, Mar. 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27307
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv SILVA, Walter A. Eyer; et al. Prevalence of HIV type 1 drug resistance mutations in treatment-naïve and experienced patients from resource-limited settings with universal access to antiretroviral therapy: a survey in two small Brazilian cities. Mem Inst Oswaldo Cruz, v.103, n.2, p.143-149, Mar. 2008.
0074-0276
1678-8060
url https://www.arca.fiocruz.br/handle/icict/27307
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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