Candida infective endocarditis: an observational cohort study with a focus on therapy

Detalhes bibliográficos
Autor(a) principal: Arnold, Christopher J.
Data de Publicação: 2015
Outros Autores: Johnson, Melissa, Bayer, Arnold S., Bradley, Suzanne, Giannitsioti, Efthymia, Miró, José M., Tornos, Pilar, Tattevin, Pierre, Strahilevitz, Jacob, Spelman, Denis, Athan, Eugene, Nacinovich, Francisco, Fortes, Claudio Q., Lamas, Cristiane, Barsic, Bruno, Fernández-Hidalgo, Nuria, Muñoz, Patricia, Chu, Vivian H., ICE Investigators
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34734
Resumo: Cristiane Lamas. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Arnold, Christopher J.Johnson, MelissaBayer, Arnold S.Bradley, SuzanneGiannitsioti, EfthymiaMiró, José M.Tornos, PilarTattevin, PierreStrahilevitz, JacobSpelman, DenisAthan, EugeneNacinovich, FranciscoFortes, Claudio Q.Lamas, CristianeBarsic, BrunoFernández-Hidalgo, NuriaMuñoz, PatriciaChu, Vivian H.ICE Investigators2019-08-12T15:13:58Z2019-08-12T15:13:58Z2015ARNOLD, Christopher J. et al. Candida infective endocarditis: an observational cohort study with a focus on therapy. Antimicrobial Agents and Chemotherapy, v. 59, n. 4, p. 2365-2373, Apr. 2015.0066-4804https://www.arca.fiocruz.br/handle/icict/3473410.1128/AAC.04867-141098-6596Cristiane Lamas. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2020-02-12Duke University Medical Center. Durham, NC, USA.Duke University Medical Center. Durham, NC, USA.Harbor-UCLA Medical Center. Los Angeles, CA, USA.University of Michigan. Ann Arbor, MI, USA / VA Ann Arbor Healthcare System. Ann Arbor, MI, USA.Attikon University General Hospital. Athens, Greece.University of Barcelona. Hospital Clinic-IDIBAPS. Barcelona, Spain.Universitat Autònoma de Barcelona. Hospital Universitari Vall d’Hebron. Barcelona, Spain.Pontchaillou University. Rennes, France.Hadassah-Hebrew University. Jerusalem, Israel.Alfred Hospital and Monash University. Melbourne, Australia.Barwon Health. Geelong, Australia.Instituto Cardiovascular de Buenos Aires. Buenos Aires, Argentina.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Universidade do Grande Rio. Duque de Caxias, RJ, Brasil.University Hospital for Infectious Diseases. Zagreb, Croatia.Universitat Autònoma de Barcelona. Hospital Universitari Vall d’Hebron. Barcelona, Spain.Hospital General Universitario Gregorio Marañón. Madrid, Spain.Duke University Medical Center. Durham, NC, USA.Candida infective endocarditis is a rare disease with a high mortality rate. Our understanding of this infection is derived from case series, case reports, and small prospective cohorts. The purpose of this study was to evaluate the clinical features and use of different antifungal treatment regimens for Candida infective endocarditis. This prospective cohort study was based on 70 cases of Candida infective endocarditis from the International Collaboration on Endocarditis (ICE)-Prospective Cohort Study and ICE-Plus databases collected between 2000 and 2010. The majority of infections were acquired nosocomially (67%). Congestive heart failure (24%), prosthetic heart valve (46%), and previous infective endocarditis (26%) were common comorbidities. Overall mortality was high, with 36% mortality in the hospital and 59% at 1 year. On univariate analysis, older age, heart failure at baseline, persistent candidemia, nosocomial acquisition, heart failure as a complication, and intracardiac abscess were associated with higher mortality. Mortality was not affected by use of surgical therapy or choice of antifungal agent. A subgroup analysis was performed on 33 patients for whom specific antifungal therapy information was available. In this subgroup, 11 patients received amphotericin B-based therapy and 14 received echinocandin-based therapy. Despite a higher percentage of older patients and nosocomial infection in the echinocandin group, mortality rates were similar between the two groups. In conclusion, Candida infective endocarditis is associated with a high mortality rate that was not impacted by choice of antifungal therapy or by adjunctive surgical intervention. Additionally, echinocandin therapy was as effective as amphotericin B-based therapy in the small subgroup analysis.engAmerican Society for MicrobiologyCandida infective endocarditis: an observational cohort study with a focus on therapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCandida infective endocarditisTreatmentMortalityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/34734/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Arnold_Christopher_etal_INI_2015.pdfve_Arnold_Christopher_etal_INI_2015.pdfapplication/pdf206587https://www.arca.fiocruz.br/bitstream/icict/34734/2/ve_Arnold_Christopher_etal_INI_2015.pdfbd5c30f10c06aa4a457380aa0656c390MD52TEXTve_Arnold_Christopher_etal_INI_2015.pdf.txtve_Arnold_Christopher_etal_INI_2015.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Candida infective endocarditis: an observational cohort study with a focus on therapy
title Candida infective endocarditis: an observational cohort study with a focus on therapy
spellingShingle Candida infective endocarditis: an observational cohort study with a focus on therapy
Arnold, Christopher J.
Candida infective endocarditis
Treatment
Mortality
title_short Candida infective endocarditis: an observational cohort study with a focus on therapy
title_full Candida infective endocarditis: an observational cohort study with a focus on therapy
title_fullStr Candida infective endocarditis: an observational cohort study with a focus on therapy
title_full_unstemmed Candida infective endocarditis: an observational cohort study with a focus on therapy
title_sort Candida infective endocarditis: an observational cohort study with a focus on therapy
author Arnold, Christopher J.
author_facet Arnold, Christopher J.
Johnson, Melissa
Bayer, Arnold S.
Bradley, Suzanne
Giannitsioti, Efthymia
Miró, José M.
Tornos, Pilar
Tattevin, Pierre
Strahilevitz, Jacob
Spelman, Denis
Athan, Eugene
Nacinovich, Francisco
Fortes, Claudio Q.
Lamas, Cristiane
Barsic, Bruno
Fernández-Hidalgo, Nuria
Muñoz, Patricia
Chu, Vivian H.
ICE Investigators
author_role author
author2 Johnson, Melissa
Bayer, Arnold S.
Bradley, Suzanne
Giannitsioti, Efthymia
Miró, José M.
Tornos, Pilar
Tattevin, Pierre
Strahilevitz, Jacob
Spelman, Denis
Athan, Eugene
Nacinovich, Francisco
Fortes, Claudio Q.
Lamas, Cristiane
Barsic, Bruno
Fernández-Hidalgo, Nuria
Muñoz, Patricia
Chu, Vivian H.
ICE Investigators
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Arnold, Christopher J.
Johnson, Melissa
Bayer, Arnold S.
Bradley, Suzanne
Giannitsioti, Efthymia
Miró, José M.
Tornos, Pilar
Tattevin, Pierre
Strahilevitz, Jacob
Spelman, Denis
Athan, Eugene
Nacinovich, Francisco
Fortes, Claudio Q.
Lamas, Cristiane
Barsic, Bruno
Fernández-Hidalgo, Nuria
Muñoz, Patricia
Chu, Vivian H.
ICE Investigators
dc.subject.en.pt_BR.fl_str_mv Candida infective endocarditis
Treatment
Mortality
topic Candida infective endocarditis
Treatment
Mortality
description Cristiane Lamas. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-08-12T15:13:58Z
dc.date.available.fl_str_mv 2019-08-12T15:13:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv ARNOLD, Christopher J. et al. Candida infective endocarditis: an observational cohort study with a focus on therapy. Antimicrobial Agents and Chemotherapy, v. 59, n. 4, p. 2365-2373, Apr. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34734
dc.identifier.issn.pt_BR.fl_str_mv 0066-4804
dc.identifier.doi.none.fl_str_mv 10.1128/AAC.04867-14
dc.identifier.eissn.none.fl_str_mv 1098-6596
identifier_str_mv ARNOLD, Christopher J. et al. Candida infective endocarditis: an observational cohort study with a focus on therapy. Antimicrobial Agents and Chemotherapy, v. 59, n. 4, p. 2365-2373, Apr. 2015.
0066-4804
10.1128/AAC.04867-14
1098-6596
url https://www.arca.fiocruz.br/handle/icict/34734
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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