Outbreak of a carbapenem-resistant XDR Acinetobacter 1 baumannii belonging to the International Clone II (IC2) in a clinical setting in Brazil, 2022
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/58922 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil. |
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Fonseca, Érica Lourenço daMorgado, Sérgio MascarenhasFreitas, Fernanda dos SantosOliveira, Priscila P. C.Monteiro, Priscilla M.Lima, Lorena S.Santos, Bianca P.Sousa, Maria Aparecida R.Assunção, Adriana O.Mascarenhas, Luís AffonsoVicente, Ana Carolina Paulo2023-06-04T19:59:37Z2023-06-04T19:59:37Z2023FONSECA, Érica Lourenço da et al. Outbreak of a carbapenem-resistant XDR Acinetobacter 1 baumannii belonging to the International Clone II (IC2) in a clinical setting in Brazil, 2022. MedRxiv, p. 1-25, May 2023.https://www.arca.fiocruz.br/handle/icict/5892210.1101/2023.05.12.23289862engmedRxiv preprintClone internacionalExtensivamente resistente a drogasBraço AOXA-23Resistência à TgeciclinaInternational cloneCRABExtensively drug resistancearmAOXA-23Tgecycline resistanceOutbreak of a carbapenem-resistant XDR Acinetobacter 1 baumannii belonging to the International Clone II (IC2) in a clinical setting in Brazil, 2022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.Hospital São Francisco na Providência na Providência de Deus. Comitê de Controle de Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Hospital São Francisco na Providência na Providência de Deus. Comitê de Controle de Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Hospital São Francisco na Providência na Providência de Deus. Comitê de Controle de Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Hospital São Francisco na Providência na Providência de Deus. Comitê de Controle de Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Hospital São Francisco na Providência na Providência de Deus. Comitê de Controle de Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Hospital São Francisco na Providência na Providência de Deus. Comitê de Controle de Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Hospital São Francisco na Providência na Providência de Deus. Comitê de Controle de Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.Carbapenem-resistant Acinetobacter baumannii (CRAB) is a leading cause of nosocomial infections worldwide, and the occurrence of extensively drug-resistant XDR) lineages among them is increasing. Most of A. baumannii pandemic lineages, known as International clones, are represented by MDR/XDR CRAB strains. The IC2 isconsidered one of the most successful and widespread pandemic clones, however, it is rare in South America, where IC1, IC4 and IC5 are prevalent. In Brazil, besides sporadic reports, an IC2 outbreak was reported only once in São Paulo city during the COVID-19 pandemics. This study characterized an outbreak caused by IC2 strains (n=16) in a hospital in Rio de Janeiro in 2022. MLST (MLST Pasteur scheme) analysis revealed that all strains recovered from nosocomial infections belonged to ST2 and corresponded to CRAB presenting the XDR phenotype. In general, this broad resistance spectrum was explained by the presence of several antibiotic resistance genes (ARGs) (armA, blaTEM, blaOXA-23, blaOXA-66, and aacA4-catB8-aadA1-qacEΔ1/sul1 carried in class 1 integron). Interestingly, the strains characterized here presented a broader resistance spectrum compared to those of the unique other and contemporary IC2 outbreak in Brazil, although they shared most of the ARGs. This study stressed the possibility of the successful establishment of IC2 in Brazilian clinical settings during and after the COVID-19 pandemics in response to a series of events, such as the overuse of antibiotics, during that period.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58922/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALEricaFonseca_AnaCarolinaVicente_etal_IOC_2023.pdfEricaFonseca_AnaCarolinaVicente_etal_IOC_2023.pdfapplication/pdf115367https://www.arca.fiocruz.br/bitstream/icict/58922/2/EricaFonseca_AnaCarolinaVicente_etal_IOC_2023.pdfd20e8b79e8f9f8616b010dae4033bf89MD52icict/589222023-06-05 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| dc.title.en_US.fl_str_mv |
Outbreak of a carbapenem-resistant XDR Acinetobacter 1 baumannii belonging to the International Clone II (IC2) in a clinical setting in Brazil, 2022 |
| title |
Outbreak of a carbapenem-resistant XDR Acinetobacter 1 baumannii belonging to the International Clone II (IC2) in a clinical setting in Brazil, 2022 |
| spellingShingle |
Outbreak of a carbapenem-resistant XDR Acinetobacter 1 baumannii belonging to the International Clone II (IC2) in a clinical setting in Brazil, 2022 Fonseca, Érica Lourenço da Clone internacional Extensivamente resistente a drogas Braço A OXA-23 Resistência à Tgeciclina International clone CRAB Extensively drug resistance armA OXA-23 Tgecycline resistance |
| title_short |
Outbreak of a carbapenem-resistant XDR Acinetobacter 1 baumannii belonging to the International Clone II (IC2) in a clinical setting in Brazil, 2022 |
| title_full |
Outbreak of a carbapenem-resistant XDR Acinetobacter 1 baumannii belonging to the International Clone II (IC2) in a clinical setting in Brazil, 2022 |
| title_fullStr |
Outbreak of a carbapenem-resistant XDR Acinetobacter 1 baumannii belonging to the International Clone II (IC2) in a clinical setting in Brazil, 2022 |
| title_full_unstemmed |
Outbreak of a carbapenem-resistant XDR Acinetobacter 1 baumannii belonging to the International Clone II (IC2) in a clinical setting in Brazil, 2022 |
| title_sort |
Outbreak of a carbapenem-resistant XDR Acinetobacter 1 baumannii belonging to the International Clone II (IC2) in a clinical setting in Brazil, 2022 |
| author |
Fonseca, Érica Lourenço da |
| author_facet |
Fonseca, Érica Lourenço da Morgado, Sérgio Mascarenhas Freitas, Fernanda dos Santos Oliveira, Priscila P. C. Monteiro, Priscilla M. Lima, Lorena S. Santos, Bianca P. Sousa, Maria Aparecida R. Assunção, Adriana O. Mascarenhas, Luís Affonso Vicente, Ana Carolina Paulo |
| author_role |
author |
| author2 |
Morgado, Sérgio Mascarenhas Freitas, Fernanda dos Santos Oliveira, Priscila P. C. Monteiro, Priscilla M. Lima, Lorena S. Santos, Bianca P. Sousa, Maria Aparecida R. Assunção, Adriana O. Mascarenhas, Luís Affonso Vicente, Ana Carolina Paulo |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Fonseca, Érica Lourenço da Morgado, Sérgio Mascarenhas Freitas, Fernanda dos Santos Oliveira, Priscila P. C. Monteiro, Priscilla M. Lima, Lorena S. Santos, Bianca P. Sousa, Maria Aparecida R. Assunção, Adriana O. Mascarenhas, Luís Affonso Vicente, Ana Carolina Paulo |
| dc.subject.other.en_US.fl_str_mv |
Clone internacional Extensivamente resistente a drogas Braço A OXA-23 Resistência à Tgeciclina |
| topic |
Clone internacional Extensivamente resistente a drogas Braço A OXA-23 Resistência à Tgeciclina International clone CRAB Extensively drug resistance armA OXA-23 Tgecycline resistance |
| dc.subject.en.en_US.fl_str_mv |
International clone CRAB Extensively drug resistance armA OXA-23 Tgecycline resistance |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil. |
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2023 |
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2023-06-04T19:59:37Z |
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2023-06-04T19:59:37Z |
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2023 |
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info:eu-repo/semantics/article |
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FONSECA, Érica Lourenço da et al. Outbreak of a carbapenem-resistant XDR Acinetobacter 1 baumannii belonging to the International Clone II (IC2) in a clinical setting in Brazil, 2022. MedRxiv, p. 1-25, May 2023. |
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https://www.arca.fiocruz.br/handle/icict/58922 |
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10.1101/2023.05.12.23289862 |
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FONSECA, Érica Lourenço da et al. Outbreak of a carbapenem-resistant XDR Acinetobacter 1 baumannii belonging to the International Clone II (IC2) in a clinical setting in Brazil, 2022. MedRxiv, p. 1-25, May 2023. 10.1101/2023.05.12.23289862 |
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