Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study

Detalhes bibliográficos
Autor(a) principal: Ferreira, Stephany Vasco
Data de Publicação: 2016
Outros Autores: Xavier, Flávia Caló Aquino, Freitas, Maria da Conceição Andrade de, Nunes, Fábio Daumas, Gurgel, Clarissa Araújo, Cangussu, Maria Cristina Teixeira, Martins, Manoela Domingues, Freitas, Valéria Souza, Santos, Jean Nunes dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18351
Resumo: CNPq
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spelling Ferreira, Stephany VascoXavier, Flávia Caló AquinoFreitas, Maria da Conceição Andrade deNunes, Fábio DaumasGurgel, Clarissa AraújoCangussu, Maria Cristina TeixeiraMartins, Manoela DominguesFreitas, Valéria SouzaSantos, Jean Nunes dos2017-04-10T19:15:06Z2017-04-10T19:15:06Z2016FERREIRA, S. V. et al. Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study. Pathology – Research and Practice, v. 212, p. 761–766. 2016.0344-0338https://www.arca.fiocruz.br/handle/icict/1835110.1016/j.prp.2016.05.007CNPqFederal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, BrazilFederal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, BrazilState University of Southwest Bahia. School of Dentistry. Jequié, BA, BrazilUniversity of São Paulo. School of Dentistry. Laboratory of Molecular Pathology. São Paulo, SP, BrazilFederal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, BrazilFederal University of Bahia. School of Dentistry. Department of Dental Public Health. Salvador, BA, BrazilFederal University of Rio Grande do Sul. School of Dentistry. Department of Oral Pahology. Porto Alegre, RGS, BrazilState Universitiy of Feira de Santana. School of Dentistry. Department of Health. Feira de Santana, BA, BrazilFederal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, BrazilIn view of the similarity of clinicopathological features between reactive lesions of the oral cavity, the objective of the present study was to investigate the density of MCs (mast cells) and microvessels in a series of these lesions. Thirty-seven cases of reactive lesions including fibrous hyperplasia (FH, n=10), inflammatory fibrous hyperplasia (IFH, n=10), peripheral giant cell lesion (PGCL, n=10) and lobular capillary hemangioma (LCH, n=7) were investigated using immunohistochemistry for mast cell tryptase and CD34. For comparative purposes, central giant cell lesions (CGCL, n=5) were included. A higher MC density was observed in LCH (37.01), while CGCL exhibited the lowest density (n=8.14). There was a significant difference in MC density when all reactive lesions were compared to CGCL (p=0.001). The largest mean density of microvessels was observed in LCH (n=21.69). The smallest number was observed in CGCL (n=6.24). There was a significant difference in microvessel density when the reactive lesions were compared to CGCL (p=0.003). There was a significant and direct correlation between the density of MCs and microvessels only for IFH (p=0.048) and CGCL (p=0.005). A significant and direct correlation between the mean density of MCs and microvessels was observed when the reactive lesions were analyzed as a whole (p=0.005). Our results suggest that mast cells contribute to the connective tissue framework and angiogenic function, as well as the development, of reactive lesions of the oral cavity, including FH, IFH, LCH and PGCL.engElsevierMastócitosAngiogêneseLesões orais reativasMast cellsAngiogenesisOral reactive lesionsInvolvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18351/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFerreira SV Involvement of mast....pdfFerreira SV Involvement of 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dc.title.pt_BR.fl_str_mv Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study
title Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study
spellingShingle Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study
Ferreira, Stephany Vasco
Mastócitos
Angiogênese
Lesões orais reativas
Mast cells
Angiogenesis
Oral reactive lesions
title_short Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study
title_full Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study
title_fullStr Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study
title_full_unstemmed Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study
title_sort Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study
author Ferreira, Stephany Vasco
author_facet Ferreira, Stephany Vasco
Xavier, Flávia Caló Aquino
Freitas, Maria da Conceição Andrade de
Nunes, Fábio Daumas
Gurgel, Clarissa Araújo
Cangussu, Maria Cristina Teixeira
Martins, Manoela Domingues
Freitas, Valéria Souza
Santos, Jean Nunes dos
author_role author
author2 Xavier, Flávia Caló Aquino
Freitas, Maria da Conceição Andrade de
Nunes, Fábio Daumas
Gurgel, Clarissa Araújo
Cangussu, Maria Cristina Teixeira
Martins, Manoela Domingues
Freitas, Valéria Souza
Santos, Jean Nunes dos
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, Stephany Vasco
Xavier, Flávia Caló Aquino
Freitas, Maria da Conceição Andrade de
Nunes, Fábio Daumas
Gurgel, Clarissa Araújo
Cangussu, Maria Cristina Teixeira
Martins, Manoela Domingues
Freitas, Valéria Souza
Santos, Jean Nunes dos
dc.subject.other.pt_BR.fl_str_mv Mastócitos
Angiogênese
Lesões orais reativas
topic Mastócitos
Angiogênese
Lesões orais reativas
Mast cells
Angiogenesis
Oral reactive lesions
dc.subject.en.pt_BR.fl_str_mv Mast cells
Angiogenesis
Oral reactive lesions
description CNPq
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-04-10T19:15:06Z
dc.date.available.fl_str_mv 2017-04-10T19:15:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERREIRA, S. V. et al. Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study. Pathology – Research and Practice, v. 212, p. 761–766. 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18351
dc.identifier.issn.pt_BR.fl_str_mv 0344-0338
dc.identifier.doi.none.fl_str_mv 10.1016/j.prp.2016.05.007
identifier_str_mv FERREIRA, S. V. et al. Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study. Pathology – Research and Practice, v. 212, p. 761–766. 2016.
0344-0338
10.1016/j.prp.2016.05.007
url https://www.arca.fiocruz.br/handle/icict/18351
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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