Impaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV/AIDS Patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/41918 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. |
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Silva-Freitas, Maria LucianaCorrêa-Castro, GabrielaCota, Glaucia FernandesGiacoia-Gripp, CarmemRabello, Ana Lucia TelesDutra, Juliana TeixeiraVasconcelos, Zilton Farias Meira deSavino, WilsonDa-Cruz, Alda MariaSantos-Oliveira, Joanna Reis2020-06-26T19:05:11Z2020-06-26T19:05:11Z2020SILVA-FREITAS, Maria Luciana et al. Impaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV/AIDS Patients. Frontiers in Immunology, v. 11, p. 1-14, 2020.1664-3224https://www.arca.fiocruz.br/handle/icict/4191810.3389/fimmu.2020.00953engFrontiers Research FoundationImpaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV/AIDS Patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil /Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro. Núcleo de Ciências Biomédicas Aplicadas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Centro de Referência em Leishmanioses. Belo Horizonte, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Centro de Referência em Leishmanioses. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Laboratório de Alta Complexidade. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Laboratório de Alta Complexidade. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa do Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro. Rede de Pesquisas em Saúde do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil/Rede de Pesquisas em Saúde do Estado do Rio de Janeiro / FAPERJ, Rio de Janeiro, RJ, Brazil / Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Disciplina de Parasitologia. Rio de Janeiro,RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro. Núcleo de Ciências Biomédicas Aplicadas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.Background: Visceral leishmaniasis/HIV-co-infected patients (VL/HIV) accounts for around 8% of VL reported cases in Brazil. Relapses of Leishmania infection after anti-leishmanial treatment constitute a great challenge in the clinical practice because of the disease severity and drug resistance. We have shown that non-relapsing-VL/HIV (NR-) evolved with increase of CD4+ T-cell counts and reduction of activated CD4+ and CD8+ T cells after anti-leishmanial treatment. This immune profile was not observed in relapsing-VL/HIV patients (R-), indicating a more severe immunological compromising degree. Elevated activation status may be related to a deficient immune reconstitution and could help to explain the frequent relapses in VL/HIV co-infection. Our aim was to evaluate if this gain of T cells was related to changes in the peripheral TCRVβ repertoire and inflammatory status, as well as the possible thymus involvement in the replenishment of these newly formed T lymphocytes. Methods: VL/HIV patients, grouped into non-relapsing (NR- = 6) and relapsing (R- = 12) were evaluated from the active phase up to 12 months post-treatment (mpt). HIV-infected patients (non-VL) and healthy subjects (HS) were included. The TCRVβ repertoire was evaluated ex vivo by flow cytometry, whereas the plasmatic cytokine levels were assessed by Luminex assay. To evaluate the thymic output, DNA was extracted from PBMCs for TCR rearrangement excision circles (TREC) quantification by qPCR. Results: VL/HIV cases presented an altered mobilization profile (expansions or retractions) of the TCRVβ families when compared to HS independent of the follow-up phase (p < 0.05). TCRVβ repertoire on CD4+ T-cells was more homogeneous in the NR-VL/HIV cases, but heterogeneous on CD8+ T-cells, since different Vβ-families were mobilized. NR-VL/HIV had the inflammatory pattern reduced after 6 mpt. Importantly, VL/HIV patients showed number of TREC copies lower than controls during all follow-up. An increase of recent thymic emigrants was observed in NR-VL/HIV individuals at 10 mpt compared to R- patients (p < 0.01), who maintained lower TREC contents than the HIV controls. Conclusions: VL/HIV patients that maintain the thymic function, thus generating new T-cells, seem able to replenish the T lymphocyte compartment with effector cells, then enabling parasite control.Visceral leishmaniasis/HIV-1 co-infectionThymic outputTCRVβ repertoireRelapsesImmune responseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/41918/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALImpaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV_AIDS Patients.pdfImpaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV_AIDS Patients.pdfapplication/pdf1231904https://www.arca.fiocruz.br/bitstream/icict/41918/2/Impaired%20Thymic%20Output%20Can%20Be%20Related%20to%20the%20Low%20Immune%20Reconstitution%20and%20T%20Cell%20Repertoire%20Disturbances%20in%20Relapsing%20Visceral%20Leishmaniasis%20Associated%20HIV_AIDS%20Patients.pdf72b17f8827a88aa3c42e13a3c100a719MD52TEXTImpaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV_AIDS Patients.pdf.txtImpaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV_AIDS Patients.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Impaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV/AIDS Patients |
| title |
Impaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV/AIDS Patients |
| spellingShingle |
Impaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV/AIDS Patients Silva-Freitas, Maria Luciana Visceral leishmaniasis/HIV-1 co-infection Thymic output TCRVβ repertoire Relapses Immune response |
| title_short |
Impaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV/AIDS Patients |
| title_full |
Impaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV/AIDS Patients |
| title_fullStr |
Impaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV/AIDS Patients |
| title_full_unstemmed |
Impaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV/AIDS Patients |
| title_sort |
Impaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV/AIDS Patients |
| author |
Silva-Freitas, Maria Luciana |
| author_facet |
Silva-Freitas, Maria Luciana Corrêa-Castro, Gabriela Cota, Glaucia Fernandes Giacoia-Gripp, Carmem Rabello, Ana Lucia Teles Dutra, Juliana Teixeira Vasconcelos, Zilton Farias Meira de Savino, Wilson Da-Cruz, Alda Maria Santos-Oliveira, Joanna Reis |
| author_role |
author |
| author2 |
Corrêa-Castro, Gabriela Cota, Glaucia Fernandes Giacoia-Gripp, Carmem Rabello, Ana Lucia Teles Dutra, Juliana Teixeira Vasconcelos, Zilton Farias Meira de Savino, Wilson Da-Cruz, Alda Maria Santos-Oliveira, Joanna Reis |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva-Freitas, Maria Luciana Corrêa-Castro, Gabriela Cota, Glaucia Fernandes Giacoia-Gripp, Carmem Rabello, Ana Lucia Teles Dutra, Juliana Teixeira Vasconcelos, Zilton Farias Meira de Savino, Wilson Da-Cruz, Alda Maria Santos-Oliveira, Joanna Reis |
| dc.subject.en.pt_BR.fl_str_mv |
Visceral leishmaniasis/HIV-1 co-infection Thymic output TCRVβ repertoire Relapses Immune response |
| topic |
Visceral leishmaniasis/HIV-1 co-infection Thymic output TCRVβ repertoire Relapses Immune response |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. |
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2020 |
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2020-06-26T19:05:11Z |
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2020-06-26T19:05:11Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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SILVA-FREITAS, Maria Luciana et al. Impaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV/AIDS Patients. Frontiers in Immunology, v. 11, p. 1-14, 2020. |
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https://www.arca.fiocruz.br/handle/icict/41918 |
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1664-3224 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fimmu.2020.00953 |
| identifier_str_mv |
SILVA-FREITAS, Maria Luciana et al. Impaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV/AIDS Patients. Frontiers in Immunology, v. 11, p. 1-14, 2020. 1664-3224 10.3389/fimmu.2020.00953 |
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Frontiers Research Foundation |
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Frontiers Research Foundation |
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