15-Deoxy-Delta-12,14-Prostaglandin J2 Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23111 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. |
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Coutinho, Diego S.Anjos-Valotta, Edna A.Nascimento, Caio V. M. F. doPires, Ana Lucia A.Napimoga, Marcelo H.Carvalho, Vinicius F.Torres, Rafael C.Silva, Patrícia M. R. eMartins, Marco A.2017-11-09T16:17:15Z2017-11-09T16:17:15Z2017COUTINHO, Diego S. et al. 15-Deoxy-Delta-12,14-Prostaglandin J2 inhibits lung inflammation and remodeling in Distinct Murine Models of asthma. Frontiers in Immunology, v.8, Article 140, 13p, June 2017.1664-3224https://www.arca.fiocruz.br/handle/icict/2311110.3389/fimmu.2017.00740engFrontiers MediaAsmaInflamação pulmonarAlérgenosPyroglyphidaeNegociaçãoasthmahouse dust miteallergen15d-PGJlung inflammationresolution15-Deoxy-Delta-12,14-Prostaglandin J2 Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthmainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Universidade Estadual da Zona Oeste. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Instituto e Centro de Pesquisa São Leopoldo Mandic. Campinas, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.15-deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) has been described as an anti-inflammatory lipid mediator in several in vitro and in vivo studies, but its effect on allergic pulmonary inflammation remains elusive. The aim of this study was to investigate the therapeutic potential of 15d-PGJ2 based on distinct murine models of allergic asthma triggered by either ovalbumin (OVA) or house dust mite extract (HDM). Characteristics of lung inflammation, airway hyper-reactivity (AHR), mucus exacerbation, and lung remodeling in sensitized A/J mice treated or not with 15d-PGJ2 were assessed. 15d-PGJ2 treatments were carried out systemically or topically given via subcutaneous injection or intranasal instillation, respectively. Analyses were carried out 24 h after the last allergen provocation. Irrespective of the route of administration, 15d-PGJ2 significantly inhibited the peribronchial accumulation of eosinophils and neutrophils, subepithelial fibrosis and also mucus exacerbation caused by either OVA or HDM challenge. The protective effect of 15d-PGJ2 occurred in parallel with inhibition of allergen-induced AHR and lung tissue production of pro-inflammatory cytokines, such as interleukin (IL)-5, IL-13, IL-17, and TNF-α. Finally, 15d-PGJ2 was found effective in inhibiting NF-κB phosphorylation upon HDM challenge as measured by Western blotting. In conclusion, our findings suggest that 15d-PGJ2 can reduce crucial features of asthma, including AHR, lung inflammation, and remodeling in distinct murine models of the disease. These effects are associated with a decrease in lung tissue generation of pro-inflammatory cytokines by a mechanism related to downregulation of NF-κB phosphorylation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23111/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALdiego_coutinho_etal_IOC_2017.pdfdiego_coutinho_etal_IOC_2017.pdfapplication/pdf16303015https://www.arca.fiocruz.br/bitstream/icict/23111/2/diego_coutinho_etal_IOC_2017.pdf5e23618e4dc7793bce93e453b7134e18MD52TEXTdiego_coutinho_etal_IOC_2017.pdf.txtdiego_coutinho_etal_IOC_2017.pdf.txtExtracted texttext/plain60474https://www.arca.fiocruz.br/bitstream/icict/23111/3/diego_coutinho_etal_IOC_2017.pdf.txt895797ffd0b0b58bd685aba602551794MD53icict/231112023-09-05 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| dc.title.pt_BR.fl_str_mv |
15-Deoxy-Delta-12,14-Prostaglandin J2 Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma |
| title |
15-Deoxy-Delta-12,14-Prostaglandin J2 Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma |
| spellingShingle |
15-Deoxy-Delta-12,14-Prostaglandin J2 Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma Coutinho, Diego S. Asma Inflamação pulmonar Alérgenos Pyroglyphidae Negociação asthma house dust mite allergen 15d-PGJ lung inflammation resolution |
| title_short |
15-Deoxy-Delta-12,14-Prostaglandin J2 Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma |
| title_full |
15-Deoxy-Delta-12,14-Prostaglandin J2 Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma |
| title_fullStr |
15-Deoxy-Delta-12,14-Prostaglandin J2 Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma |
| title_full_unstemmed |
15-Deoxy-Delta-12,14-Prostaglandin J2 Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma |
| title_sort |
15-Deoxy-Delta-12,14-Prostaglandin J2 Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma |
| author |
Coutinho, Diego S. |
| author_facet |
Coutinho, Diego S. Anjos-Valotta, Edna A. Nascimento, Caio V. M. F. do Pires, Ana Lucia A. Napimoga, Marcelo H. Carvalho, Vinicius F. Torres, Rafael C. Silva, Patrícia M. R. e Martins, Marco A. |
| author_role |
author |
| author2 |
Anjos-Valotta, Edna A. Nascimento, Caio V. M. F. do Pires, Ana Lucia A. Napimoga, Marcelo H. Carvalho, Vinicius F. Torres, Rafael C. Silva, Patrícia M. R. e Martins, Marco A. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Coutinho, Diego S. Anjos-Valotta, Edna A. Nascimento, Caio V. M. F. do Pires, Ana Lucia A. Napimoga, Marcelo H. Carvalho, Vinicius F. Torres, Rafael C. Silva, Patrícia M. R. e Martins, Marco A. |
| dc.subject.other.pt_BR.fl_str_mv |
Asma Inflamação pulmonar Alérgenos Pyroglyphidae Negociação |
| topic |
Asma Inflamação pulmonar Alérgenos Pyroglyphidae Negociação asthma house dust mite allergen 15d-PGJ lung inflammation resolution |
| dc.subject.en.pt_BR.fl_str_mv |
asthma house dust mite allergen 15d-PGJ lung inflammation resolution |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. |
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2017 |
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2017-11-09T16:17:15Z |
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2017-11-09T16:17:15Z |
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2017 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
COUTINHO, Diego S. et al. 15-Deoxy-Delta-12,14-Prostaglandin J2 inhibits lung inflammation and remodeling in Distinct Murine Models of asthma. Frontiers in Immunology, v.8, Article 140, 13p, June 2017. |
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https://www.arca.fiocruz.br/handle/icict/23111 |
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1664-3224 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fimmu.2017.00740 |
| identifier_str_mv |
COUTINHO, Diego S. et al. 15-Deoxy-Delta-12,14-Prostaglandin J2 inhibits lung inflammation and remodeling in Distinct Murine Models of asthma. Frontiers in Immunology, v.8, Article 140, 13p, June 2017. 1664-3224 10.3389/fimmu.2017.00740 |
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Frontiers Media |
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Frontiers Media |
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