Distinct Roles of Hemocytes at Different Stages of Infection by Dengue and Zika Viruses in Aedes aegypti Mosquitoes

Detalhes bibliográficos
Autor(a) principal: Leite, Thiago Henrique Jiran Ferreira
Data de Publicação: 2021
Outros Autores: Ferreira, Álvaro Gil Araújo, Imler, Jean-Luc, Marques, João Trindade
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51546
Resumo: Universidade Federal de Minas Gerais Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia.Belo Horizonte, MG, Brazil.
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spelling Leite, Thiago Henrique Jiran FerreiraFerreira, Álvaro Gil AraújoImler, Jean-LucMarques, João Trindade2022-03-04T13:09:09Z2022-03-04T13:09:09Z2021LEITE Thiago Henrique Jiran Ferreira, et al. Distinct Roles of Hemocytes at Different Stages of Infection by Dengue and Zika Viruses in Aedes aegypti Mosquitoes. Front Immunol., v. 12, 660873, 2021. doi: 10.3389/fimmu.2021.660873. eCollection 2021.1664-3224https://www.arca.fiocruz.br/handle/icict/5154610.3389/fimmu.2021.660873. eCollection 2021.engFrontiers Research FoundationDistinct Roles of Hemocytes at Different Stages of Infection by Dengue and Zika Viruses in Aedes aegypti Mosquitoesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia.Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia.Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Mosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor. Belo Horizonte, MG, Brazil.Université de Strasbourg. Strasbourg, France.Universidade Federal de Minas Gerais Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia.Belo Horizonte, MG, Brazil/Université de Strasbourg. Strasbourg, France.Aedes aegypti mosquitoes are vectors for arboviruses of medical importance such as dengue (DENV) and Zika (ZIKV) viruses. Different innate immune pathways contribute to the control of arboviruses in the mosquito vector including RNA interference, Toll and Jak-STAT pathways. However, the role of cellular responses mediated by circulating macrophage-like cells known as hemocytes remains unclear. Here we show that hemocytes are recruited to the midgut of Ae. aegypti mosquitoes in response to DENV or ZIKV. Blockade of the phagocytic function of hemocytes using latex beads induced increased accumulation of hemocytes in the midgut and a reduction in virus infection levels in this organ. In contrast, inhibition of phagocytosis by hemocytes led to increased systemic dissemination and replication of DENV and ZIKV. Hence, our work reveals a dual role for hemocytes in Ae. aegypti mosquitoes, whereby phagocytosis is not required to control viral infection in the midgut but is essential to restrict systemic dissemination. Further understanding of the mechanism behind this duality could help the design of vector-based strategies to prevent transmission of arboviruses.Aedes aegyptiZika viruscellular immunitydengue virushemocytesmacrophage-like cellsvector mosquitoesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/51546/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALDistinct Roles of Hemocytes at Different Stages.pdfDistinct Roles of Hemocytes at Different Stages.pdfapplication/pdf5594352https://www.arca.fiocruz.br/bitstream/icict/51546/2/Distinct%20Roles%20of%20Hemocytes%20at%20Different%20Stages.pdf10bc19ace796aafd7574c9a65477f024MD52icict/515462022-03-04 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dc.title.pt_BR.fl_str_mv Distinct Roles of Hemocytes at Different Stages of Infection by Dengue and Zika Viruses in Aedes aegypti Mosquitoes
title Distinct Roles of Hemocytes at Different Stages of Infection by Dengue and Zika Viruses in Aedes aegypti Mosquitoes
spellingShingle Distinct Roles of Hemocytes at Different Stages of Infection by Dengue and Zika Viruses in Aedes aegypti Mosquitoes
Leite, Thiago Henrique Jiran Ferreira
Aedes aegypti
Zika virus
cellular immunity
dengue virus
hemocytes
macrophage-like cells
vector mosquitoes
title_short Distinct Roles of Hemocytes at Different Stages of Infection by Dengue and Zika Viruses in Aedes aegypti Mosquitoes
title_full Distinct Roles of Hemocytes at Different Stages of Infection by Dengue and Zika Viruses in Aedes aegypti Mosquitoes
title_fullStr Distinct Roles of Hemocytes at Different Stages of Infection by Dengue and Zika Viruses in Aedes aegypti Mosquitoes
title_full_unstemmed Distinct Roles of Hemocytes at Different Stages of Infection by Dengue and Zika Viruses in Aedes aegypti Mosquitoes
title_sort Distinct Roles of Hemocytes at Different Stages of Infection by Dengue and Zika Viruses in Aedes aegypti Mosquitoes
author Leite, Thiago Henrique Jiran Ferreira
author_facet Leite, Thiago Henrique Jiran Ferreira
Ferreira, Álvaro Gil Araújo
Imler, Jean-Luc
Marques, João Trindade
author_role author
author2 Ferreira, Álvaro Gil Araújo
Imler, Jean-Luc
Marques, João Trindade
author2_role author
author
author
dc.contributor.author.fl_str_mv Leite, Thiago Henrique Jiran Ferreira
Ferreira, Álvaro Gil Araújo
Imler, Jean-Luc
Marques, João Trindade
dc.subject.en.pt_BR.fl_str_mv Aedes aegypti
Zika virus
cellular immunity
dengue virus
hemocytes
macrophage-like cells
vector mosquitoes
topic Aedes aegypti
Zika virus
cellular immunity
dengue virus
hemocytes
macrophage-like cells
vector mosquitoes
description Universidade Federal de Minas Gerais Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia.Belo Horizonte, MG, Brazil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-03-04T13:09:09Z
dc.date.available.fl_str_mv 2022-03-04T13:09:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LEITE Thiago Henrique Jiran Ferreira, et al. Distinct Roles of Hemocytes at Different Stages of Infection by Dengue and Zika Viruses in Aedes aegypti Mosquitoes. Front Immunol., v. 12, 660873, 2021. doi: 10.3389/fimmu.2021.660873. eCollection 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51546
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2021.660873. eCollection 2021.
identifier_str_mv LEITE Thiago Henrique Jiran Ferreira, et al. Distinct Roles of Hemocytes at Different Stages of Infection by Dengue and Zika Viruses in Aedes aegypti Mosquitoes. Front Immunol., v. 12, 660873, 2021. doi: 10.3389/fimmu.2021.660873. eCollection 2021.
1664-3224
10.3389/fimmu.2021.660873. eCollection 2021.
url https://www.arca.fiocruz.br/handle/icict/51546
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51546/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51546/2/Distinct%20Roles%20of%20Hemocytes%20at%20Different%20Stages.pdf
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MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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