Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40818 |
Resumo: | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia de Anticorpos Monoclonais. Rio de Janeiro, RJ, Brasil. |
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Conte, Fernando de PaivaTinoco, Bianca CorrêaChaves, Thiago SantosOliveira, Renata Carvalho deMansur, Janaina FigueiraMohana-Borges, RonaldoLemos, Elba Regina S.Neves, Patricia Cristina da CostaSilva, Rodrigo Nunes Rodrigues da2020-04-17T13:37:10Z2020-04-17T13:37:10Z2019CONDE, Fernando de Paiva et al. Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome. PLoS Neglected Tropical Diseases, v. 13, n. 12, p. 1-15, Dec. 2019.1932-2727https://www.arca.fiocruz.br/handle/icict/4081810.1371/journal.pntd.00079151935-2735engPublic Library of ScienceHantavírusEpítopos de Células BFebre hemorrágicaSindrome renalB-cell epitopesHantavirusesHemorrhagic feveRenal syndromeIdentification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia de Anticorpos Monoclonais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia de Anticorpos Monoclonais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia de Anticorpos Monoclonais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório Genômica Estrutural. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório Genômica Estrutural. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia de Anticorpos Monoclonais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia de Anticorpos Monoclonais. Rio de Janeiro, RJ, Brasil.Orthohantavirus infection is a neglected global health problem affecting approximately 200,000 people/year, spread by rodent hosts and associated to fatal human diseases, such as hemorrhagic fever with renal syndrome (HFRS) and orthohantavirus cardiopulmonary syndrome (HCPS). Circulation of HFRS-associated orthohantaviruses, such as Seoul, Gou, Amur, Dobrava and Hantaan, are supposed to be restricted to Eurasian countries even though their hosts can be a worldwide distribution. Few confirmed HFRS orthohantavirus infections in humans have been reported in American countries, but due to lower medical awareness of the symptoms of this zoonosis, it could be associated to viral underreporting or to misdiagnosis with several tropical hemorrhagic diseases. Serological evidence of orthohantavirus infections, using enzyme-linked immunosorbent assay for the presence of immunoglobulin M and G against recombinant nucleoprotein protein, remains as an essential assay for viral surveillance. In this study, we aimed to identify in silico immunogenic B-cell linear epitopes present on orthohantavirus nucleoprotein that are exclusive to HFRS-related species.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40818/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFernandoCOnte_ElbaRSLemos_etal_IOC_2019.pdfFernandoCOnte_ElbaRSLemos_etal_IOC_2019.pdfapplication/pdf1072709https://www.arca.fiocruz.br/bitstream/icict/40818/2/FernandoCOnte_ElbaRSLemos_etal_IOC_2019.pdf393a73fa83e53323842be22316d28e4aMD52TEXTFernandoCOnte_ElbaRSLemos_etal_IOC_2019.pdf.txtFernandoCOnte_ElbaRSLemos_etal_IOC_2019.pdf.txtExtracted texttext/plain55012https://www.arca.fiocruz.br/bitstream/icict/40818/3/FernandoCOnte_ElbaRSLemos_etal_IOC_2019.pdf.txte5fc65b8f56aae7571eca9fe978e4a99MD53icict/408182020-04-20 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dc.title.pt_BR.fl_str_mv |
Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome |
title |
Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome |
spellingShingle |
Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome Conte, Fernando de Paiva Hantavírus Epítopos de Células B Febre hemorrágica Sindrome renal B-cell epitopes Hantaviruses Hemorrhagic feve Renal syndrome |
title_short |
Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome |
title_full |
Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome |
title_fullStr |
Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome |
title_full_unstemmed |
Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome |
title_sort |
Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome |
author |
Conte, Fernando de Paiva |
author_facet |
Conte, Fernando de Paiva Tinoco, Bianca Corrêa Chaves, Thiago Santos Oliveira, Renata Carvalho de Mansur, Janaina Figueira Mohana-Borges, Ronaldo Lemos, Elba Regina S. Neves, Patricia Cristina da Costa Silva, Rodrigo Nunes Rodrigues da |
author_role |
author |
author2 |
Tinoco, Bianca Corrêa Chaves, Thiago Santos Oliveira, Renata Carvalho de Mansur, Janaina Figueira Mohana-Borges, Ronaldo Lemos, Elba Regina S. Neves, Patricia Cristina da Costa Silva, Rodrigo Nunes Rodrigues da |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Conte, Fernando de Paiva Tinoco, Bianca Corrêa Chaves, Thiago Santos Oliveira, Renata Carvalho de Mansur, Janaina Figueira Mohana-Borges, Ronaldo Lemos, Elba Regina S. Neves, Patricia Cristina da Costa Silva, Rodrigo Nunes Rodrigues da |
dc.subject.other.pt_BR.fl_str_mv |
Hantavírus Epítopos de Células B Febre hemorrágica Sindrome renal |
topic |
Hantavírus Epítopos de Células B Febre hemorrágica Sindrome renal B-cell epitopes Hantaviruses Hemorrhagic feve Renal syndrome |
dc.subject.en.pt_BR.fl_str_mv |
B-cell epitopes Hantaviruses Hemorrhagic feve Renal syndrome |
description |
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia de Anticorpos Monoclonais. Rio de Janeiro, RJ, Brasil. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019 |
dc.date.accessioned.fl_str_mv |
2020-04-17T13:37:10Z |
dc.date.available.fl_str_mv |
2020-04-17T13:37:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CONDE, Fernando de Paiva et al. Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome. PLoS Neglected Tropical Diseases, v. 13, n. 12, p. 1-15, Dec. 2019. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/40818 |
dc.identifier.issn.pt_BR.fl_str_mv |
1932-2727 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0007915 |
dc.identifier.eissn.none.fl_str_mv |
1935-2735 |
identifier_str_mv |
CONDE, Fernando de Paiva et al. Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome. PLoS Neglected Tropical Diseases, v. 13, n. 12, p. 1-15, Dec. 2019. 1932-2727 10.1371/journal.pntd.0007915 1935-2735 |
url |
https://www.arca.fiocruz.br/handle/icict/40818 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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Public Library of Science |
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Public Library of Science |
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