Expression of VCAN and its receptors in canine mammary carcinomas with or without myoepithelial proliferation

Detalhes bibliográficos
Autor(a) principal: Figueredo, S.H.
Data de Publicação: 2021
Outros Autores: Carmo Neto, R.S., Ferreira, E., Cassali, G. D., Lima, Estrela, Damasceno, K. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/49074
Resumo: Research Center on Mammary Oncology NPqOM/HOSPMEV/UFBA and Comparative Pathology laboratory (UFMG)
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spelling Figueredo, S.H.Carmo Neto, R.S.Ferreira, E.Cassali, G. D.Lima, EstrelaDamasceno, K. A.2021-09-14T12:49:02Z2021-09-14T12:49:02Z2021FIGUEIREDO, S. H. et al. Expression of VCAN and its receptors in canine mammary carcinomas with or without myoepithelial proliferation. TitleResearch in Veterinary Science, 2021.0034-5288https://www.arca.fiocruz.br/handle/icict/49074/10.1016/j.rvsc.2021.08.010Research Center on Mammary Oncology NPqOM/HOSPMEV/UFBA and Comparative Pathology laboratory (UFMG)Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Bahia, Brasil.Federal University of Bahia. School of Veterinary Medicine and Zootechny. Department of Pathology and Clinics. Salvador, BA, BrazilFederal University of Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.Federal University of Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.Federal University of Bahia. School of Veterinary Medicine and Zootechny. Department of Pathology and Clinics. Salvador, BA, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Bahia, Brasil.The proteoglycan versican (VCAN) plays a complex role in cancer. The expression of this molecule has been related to invasion and progression in malignant mixed tumors, such as carcinoma in mixed tumors (CMT) of the canine mammary gland. In addition, its interaction with surface cell receptors EGFR, HER-2 and CD44 in malignant epithelial cells may be responsible for proliferation and cellular motility in early stages of cancer. We comparatively evaluated the expression of this proteoglycan and its receptors in in situ and invasive areas of simple carcinomas (SC) and CMT to investigate similarities and differences between these histological types. Immunohistochemistry was performed with anti-VCAN, anti-CD44, anti-EGFR and anti-HER-2 antibodies in 32 cases of SC or CMT. VCAN was highly expressed in stroma adjacent to invasive areas in SC and CMT. CMTs presented comparatively higher expression of VCAN in stroma adjacent to in situ and in invasive areas than in corresponding areas in SCs. In CMT, EGFR and HER-2 expressions were higher in situ compared to invasive areas. In contrast, increased CD44 and EGFR expression was found in invasive areas in SC compared to CMT. These results indicate that versican expression is similarly associated with invasiveness in SC and CMT, however higher levels were seen in CMT suggesting that the presence of myoepithelial proliferation in this tumor type participates in stromal composition and promoting an increase in the expression of versican.engElsevierCarcinomaCélulas epiteliaisMatriz extracelularImuno-histoquímicaAnticorposCanineCancer progressionExtracellular matrixVersicanExpression of VCAN and its receptors in canine mammary carcinomas with or without myoepithelial proliferationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/49074/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALFigueredo, S. H. Expression....pdfFigueredo, S. H. 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dc.title.pt_BR.fl_str_mv Expression of VCAN and its receptors in canine mammary carcinomas with or without myoepithelial proliferation
title Expression of VCAN and its receptors in canine mammary carcinomas with or without myoepithelial proliferation
spellingShingle Expression of VCAN and its receptors in canine mammary carcinomas with or without myoepithelial proliferation
Figueredo, S.H.
Carcinoma
Células epiteliais
Matriz extracelular
Imuno-histoquímica
Anticorpos
Canine
Cancer progression
Extracellular matrix
Versican
title_short Expression of VCAN and its receptors in canine mammary carcinomas with or without myoepithelial proliferation
title_full Expression of VCAN and its receptors in canine mammary carcinomas with or without myoepithelial proliferation
title_fullStr Expression of VCAN and its receptors in canine mammary carcinomas with or without myoepithelial proliferation
title_full_unstemmed Expression of VCAN and its receptors in canine mammary carcinomas with or without myoepithelial proliferation
title_sort Expression of VCAN and its receptors in canine mammary carcinomas with or without myoepithelial proliferation
author Figueredo, S.H.
author_facet Figueredo, S.H.
Carmo Neto, R.S.
Ferreira, E.
Cassali, G. D.
Lima, Estrela
Damasceno, K. A.
author_role author
author2 Carmo Neto, R.S.
Ferreira, E.
Cassali, G. D.
Lima, Estrela
Damasceno, K. A.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Figueredo, S.H.
Carmo Neto, R.S.
Ferreira, E.
Cassali, G. D.
Lima, Estrela
Damasceno, K. A.
dc.subject.other.pt_BR.fl_str_mv Carcinoma
Células epiteliais
Matriz extracelular
Imuno-histoquímica
Anticorpos
topic Carcinoma
Células epiteliais
Matriz extracelular
Imuno-histoquímica
Anticorpos
Canine
Cancer progression
Extracellular matrix
Versican
dc.subject.en.pt_BR.fl_str_mv Canine
Cancer progression
Extracellular matrix
Versican
description Research Center on Mammary Oncology NPqOM/HOSPMEV/UFBA and Comparative Pathology laboratory (UFMG)
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-09-14T12:49:02Z
dc.date.available.fl_str_mv 2021-09-14T12:49:02Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FIGUEIREDO, S. H. et al. Expression of VCAN and its receptors in canine mammary carcinomas with or without myoepithelial proliferation. TitleResearch in Veterinary Science, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/49074
dc.identifier.issn.pt_BR.fl_str_mv 0034-5288
dc.identifier.eissn.none.fl_str_mv /10.1016/j.rvsc.2021.08.010
identifier_str_mv FIGUEIREDO, S. H. et al. Expression of VCAN and its receptors in canine mammary carcinomas with or without myoepithelial proliferation. TitleResearch in Veterinary Science, 2021.
0034-5288
/10.1016/j.rvsc.2021.08.010
url https://www.arca.fiocruz.br/handle/icict/49074
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/49074/3/Figueredo%2c%20S.%20H.%20Expression....pdf.txt
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