Prediabetes induces more severe acute COVID-19 associated with IL-6 production without worsening long-term symptoms

Detalhes bibliográficos
Autor(a) principal: Silva, Icaro Bonyek
Data de Publicação: 2022
Outros Autores: Silva, Thiago Cerqueira, Nunes, Sara, Machado, Antônio Fernando Araújo, Cruz, Márrcio Rivison Silva, Pereira, Blenda, Estrela, Leilane, Silva, Jéssica, Isis, Ananda, Barral, Aldina, Oliveira, Pablo Rafael Silveira, Khouri, Ricardo, Serezani, C. Henrique, Brodskyn, Cláudia, Caldas, Juliana Ribeiro, Barral Netto, Manoel, Boaventura, Viviane, Tavares, Natalia Machado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/54492
Resumo: Inova Fiocruz – Fundação Oswaldo Cruz. Coordenação de Aperfeiçoamento de Pessoal da Nível Superior - Brésil (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo à Projeto de Pesquisa do Estado da Bahia (FAPESB)
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spelling Silva, Icaro BonyekSilva, Thiago CerqueiraNunes, SaraMachado, Antônio Fernando AraújoCruz, Márrcio Rivison SilvaPereira, BlendaEstrela, LeilaneSilva, JéssicaIsis, AnandaBarral, AldinaOliveira, Pablo Rafael SilveiraKhouri, RicardoSerezani, C. HenriqueBrodskyn, CláudiaCaldas, Juliana RibeiroBarral Netto, ManoelBoaventura, VivianeTavares, Natalia Machado2022-08-08T17:19:06Z2022-08-08T17:19:06Z2022SILVA, Icaro Bonyek et al. Prediabetes induces more severe acute COVID-19 associated with IL-6 production without worsening long-term symptoms. Frontiers in Endocrinology, v. 13, p. 1-9, 2022.1664-2392https://www.arca.fiocruz.br/handle/icict/5449210.3389/fendo.2022.896378Inova Fiocruz – Fundação Oswaldo Cruz. Coordenação de Aperfeiçoamento de Pessoal da Nível Superior - Brésil (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo à Projeto de Pesquisa do Estado da Bahia (FAPESB)Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Federal de Educação. Ciência e Tecnologia Baiano. Xique-Xique, BA, Brasil / Faculdade de Santa Cruz da Bahia. Escola de enfermagem. Itaberaba, BA, Brasil,Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Universidade Salvador. Escola de Ciências da Saúde. Salvador, BA, Brasil.Universidade Salvador. Escola de Ciências da Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Instituto de Investigação em Imunologia. São Paulo, SP, Brasil.Universidade Federal do Bahia. Instituto de Ciências Biológicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN, United States.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Instituto de Investigação em Imunologia. São Paulo, SP, Brasil.Universidade Salvador. Escola de Ciências da Saúde. Salvador, BA, Brasil. Hospital São Rafael. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Instituto de Investigação em Imunologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Instituto de Investigação em Imunologia. São Paulo, SP, Brasil.Aims: Pre-existing conditions, such as age, hypertension, obesity, and diabetes, constitute known risk factors for severe COVID-19. However, the impact of prediabetes mellitus (PDM) on COVID-19 severity is less clear. This study aimed to evaluate the influence of PDM in the acute and long-term phases of COVID-19. Materials and methods: We compared inflammatory mediators, laboratory and clinical parameters and symptoms in COVID-19 patients with prediabetes (PDM) and without diabetes (NDM) during the acute phase of infection and at three months post-hospitalization. Results: Patients with PDM had longer hospital stays and required intensive care unit admission more frequently than NDM. Upon hospitalization, PDM patients exhibited higher serum levels of interleukin 6 (IL-6), which is related to reduced partial pressure of oxygen (PaO2) in arterial blood, oxygen saturation (SpO2) and increased COVID-19 severity. However, at three months after discharge, those with PDM did not exhibit significant alterations in laboratory parameters or residual symptoms; however, PDM was observed to influence the profile of reported symptoms. Conclusions: PDM seems to be associated with increased risk of severe COVID-19, as well as higher serum levels of IL-6, which may constitute a potential biomarker of severe COVID-19 risk in affected patients. Furthermore, while PDM correlated with more severe acute-phase COVID-19, no long-term worsening of sequelae was observed.engFrontiers MediaPrediabetic StateInflammationCOVID-19Pré-diabéticoInflamaçãoCOVID-19Interleucina-6PrediabeticInflammationCOVID-19Interleukin-6PrediabéticoInflamaciónCOVID-19Interleucina-6État prédiabétiqueInflammationSARS-CoV-2Interleukine-6Estado pré-diabéticoInflamaçãoCOVID-19Interleucina-6Prediabetes induces more severe acute COVID-19 associated with IL-6 production without worsening long-term symptomsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/54492/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSilva, Icaro Bonyek - Prediabetes Induces....pdfSilva, Icaro Bonyek - Prediabetes 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dc.title.pt_BR.fl_str_mv Prediabetes induces more severe acute COVID-19 associated with IL-6 production without worsening long-term symptoms
title Prediabetes induces more severe acute COVID-19 associated with IL-6 production without worsening long-term symptoms
spellingShingle Prediabetes induces more severe acute COVID-19 associated with IL-6 production without worsening long-term symptoms
Silva, Icaro Bonyek
Prediabetic State
Inflammation
COVID-19
Pré-diabético
Inflamação
COVID-19
Interleucina-6
Prediabetic
Inflammation
COVID-19
Interleukin-6
Prediabético
Inflamación
COVID-19
Interleucina-6
État prédiabétique
Inflammation
SARS-CoV-2
Interleukine-6
Estado pré-diabético
Inflamação
COVID-19
Interleucina-6
title_short Prediabetes induces more severe acute COVID-19 associated with IL-6 production without worsening long-term symptoms
title_full Prediabetes induces more severe acute COVID-19 associated with IL-6 production without worsening long-term symptoms
title_fullStr Prediabetes induces more severe acute COVID-19 associated with IL-6 production without worsening long-term symptoms
title_full_unstemmed Prediabetes induces more severe acute COVID-19 associated with IL-6 production without worsening long-term symptoms
title_sort Prediabetes induces more severe acute COVID-19 associated with IL-6 production without worsening long-term symptoms
author Silva, Icaro Bonyek
author_facet Silva, Icaro Bonyek
Silva, Thiago Cerqueira
Nunes, Sara
Machado, Antônio Fernando Araújo
Cruz, Márrcio Rivison Silva
Pereira, Blenda
Estrela, Leilane
Silva, Jéssica
Isis, Ananda
Barral, Aldina
Oliveira, Pablo Rafael Silveira
Khouri, Ricardo
Serezani, C. Henrique
Brodskyn, Cláudia
Caldas, Juliana Ribeiro
Barral Netto, Manoel
Boaventura, Viviane
Tavares, Natalia Machado
author_role author
author2 Silva, Thiago Cerqueira
Nunes, Sara
Machado, Antônio Fernando Araújo
Cruz, Márrcio Rivison Silva
Pereira, Blenda
Estrela, Leilane
Silva, Jéssica
Isis, Ananda
Barral, Aldina
Oliveira, Pablo Rafael Silveira
Khouri, Ricardo
Serezani, C. Henrique
Brodskyn, Cláudia
Caldas, Juliana Ribeiro
Barral Netto, Manoel
Boaventura, Viviane
Tavares, Natalia Machado
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Icaro Bonyek
Silva, Thiago Cerqueira
Nunes, Sara
Machado, Antônio Fernando Araújo
Cruz, Márrcio Rivison Silva
Pereira, Blenda
Estrela, Leilane
Silva, Jéssica
Isis, Ananda
Barral, Aldina
Oliveira, Pablo Rafael Silveira
Khouri, Ricardo
Serezani, C. Henrique
Brodskyn, Cláudia
Caldas, Juliana Ribeiro
Barral Netto, Manoel
Boaventura, Viviane
Tavares, Natalia Machado
dc.subject.mesh.pt_BR.fl_str_mv Prediabetic State
Inflammation
COVID-19
topic Prediabetic State
Inflammation
COVID-19
Pré-diabético
Inflamação
COVID-19
Interleucina-6
Prediabetic
Inflammation
COVID-19
Interleukin-6
Prediabético
Inflamación
COVID-19
Interleucina-6
État prédiabétique
Inflammation
SARS-CoV-2
Interleukine-6
Estado pré-diabético
Inflamação
COVID-19
Interleucina-6
dc.subject.other.pt_BR.fl_str_mv Pré-diabético
Inflamação
COVID-19
Interleucina-6
dc.subject.en.pt_BR.fl_str_mv Prediabetic
Inflammation
COVID-19
Interleukin-6
dc.subject.es.pt_BR.fl_str_mv Prediabético
Inflamación
COVID-19
Interleucina-6
dc.subject.fr.pt_BR.fl_str_mv État prédiabétique
Inflammation
SARS-CoV-2
Interleukine-6
dc.subject.decs.pt_BR.fl_str_mv Estado pré-diabético
Inflamação
COVID-19
Interleucina-6
description Inova Fiocruz – Fundação Oswaldo Cruz. Coordenação de Aperfeiçoamento de Pessoal da Nível Superior - Brésil (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo à Projeto de Pesquisa do Estado da Bahia (FAPESB)
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-08-08T17:19:06Z
dc.date.available.fl_str_mv 2022-08-08T17:19:06Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Icaro Bonyek et al. Prediabetes induces more severe acute COVID-19 associated with IL-6 production without worsening long-term symptoms. Frontiers in Endocrinology, v. 13, p. 1-9, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/54492
dc.identifier.issn.pt_BR.fl_str_mv 1664-2392
dc.identifier.doi.none.fl_str_mv 10.3389/fendo.2022.896378
identifier_str_mv SILVA, Icaro Bonyek et al. Prediabetes induces more severe acute COVID-19 associated with IL-6 production without worsening long-term symptoms. Frontiers in Endocrinology, v. 13, p. 1-9, 2022.
1664-2392
10.3389/fendo.2022.896378
url https://www.arca.fiocruz.br/handle/icict/54492
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/54492/1/license.txt
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