Cardiac effect induced by Crotalus durissus cascavella venom: Morphofunctional evidence and mechanism of action
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46367 |
Resumo: | Bahia State Research Support Foundation [FAPESB grant number 5198/2014], National Council for Scientific and Technological Development (CNPq) and Coordination for the Improvement of Higher Education Personnel (CAPES) - Finance Code 001. JSC, DFS, MBPS and MAVS are CNPq Research Fellows. |
| id |
CRUZ_bbb278fc8c991d0715b64c119e6452bf |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/46367 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Simões, Letícia O.Alves, Quiara L.Camargo, Samuel B.Araújo, Fênix A.Hora, Viviane R.S.Jesus, Rafael L.C.Barreto, Breno C.Macambira, Simone G.Soares, Milena Botelho PereiraMeira, Cássio S.Aguiar, Márcio C.Couto, Ricardo. D.Lomonte, BrunoMenezes Filho, José EvaldoCruz, Jader S.Santos, Marcos A. VannierSilva, Luciana L. Casais eSilva, Darizy F.2021-03-16T12:38:21Z2021-03-16T12:38:21Z2021SIMÕES, Letícia O. et al. Cardiac effect induced by Crotalus durissus cascavella venom: Morphofunctional evidence and mechanism of action. Toxicology Letters, v. 337, p. 121–133, 2021.0378-4274https://www.arca.fiocruz.br/handle/icict/4636710.1016/j.toxlet.2020.11.019Bahia State Research Support Foundation [FAPESB grant number 5198/2014], National Council for Scientific and Technological Development (CNPq) and Coordination for the Improvement of Higher Education Personnel (CAPES) - Finance Code 001. JSC, DFS, MBPS and MAVS are CNPq Research Fellows."Múltipla ver em Notas"Envenoming, resulting from snake bites, is a global public health problem. The present study was undertaken to investigate the influence of Crotalus durissus cascavella (Cdcas) venom on cardiac activity and the mechanisms of action underlying its effect. To investigate the inotropic and chronotropic effects induced by Cdcas, studies were performed on the left and right atria. A series of tests were conducted to investigate whether the negative inotropic effect, induced by Cdcas, was related to cardiac damage. Cdcas venom (0.1 30 mg/mL) elicited a significant negative inotropic effect. The addition of Cdcas crude venom (7.5, 15 and 30 mg/mL) did not induce significant alterations in cell proliferation, nor in the enzymatic activity of total-CK and CK MB. Ultrastructural evaluation demonstrated that cardiac cells from isoproterenol and Cdcas groups revealed discreet swelling and displaced intermyofibrillar mitochondriaengElsevierCrotalusCardiotoxicidadeProliferação de célulasMitocôndriasCrotalus durissus cascavellaCardiotoxicityAtrialCardiac effect induced by Crotalus durissus cascavella venom: Morphofunctional evidence and mechanism of actioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/46367/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALSimoes, Leticia O Cardiac effect....pdfSimoes, Leticia O Cardiac effect....pdfapplication/pdf5356949https://www.arca.fiocruz.br/bitstream/icict/46367/2/Simoes%2c%20Leticia%20O%20Cardiac%20effect....pdff3348d80797c5929f5f7de48b493a2c7MD52TEXTSimoes, Leticia O Cardiac effect....pdf.txtSimoes, Leticia O Cardiac effect....pdf.txtExtracted texttext/plain64079https://www.arca.fiocruz.br/bitstream/icict/46367/3/Simoes%2c%20Leticia%20O%20Cardiac%20effect....pdf.txt65df911d33e85be643543bcbb09dc1f4MD53icict/463672023-03-15 14:34:30.376oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:30Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Cardiac effect induced by Crotalus durissus cascavella venom: Morphofunctional evidence and mechanism of action |
| title |
Cardiac effect induced by Crotalus durissus cascavella venom: Morphofunctional evidence and mechanism of action |
| spellingShingle |
Cardiac effect induced by Crotalus durissus cascavella venom: Morphofunctional evidence and mechanism of action Simões, Letícia O. Crotalus Cardiotoxicidade Proliferação de células Mitocôndrias Crotalus durissus cascavella Cardiotoxicity Atrial |
| title_short |
Cardiac effect induced by Crotalus durissus cascavella venom: Morphofunctional evidence and mechanism of action |
| title_full |
Cardiac effect induced by Crotalus durissus cascavella venom: Morphofunctional evidence and mechanism of action |
| title_fullStr |
Cardiac effect induced by Crotalus durissus cascavella venom: Morphofunctional evidence and mechanism of action |
| title_full_unstemmed |
Cardiac effect induced by Crotalus durissus cascavella venom: Morphofunctional evidence and mechanism of action |
| title_sort |
Cardiac effect induced by Crotalus durissus cascavella venom: Morphofunctional evidence and mechanism of action |
| author |
Simões, Letícia O. |
| author_facet |
Simões, Letícia O. Alves, Quiara L. Camargo, Samuel B. Araújo, Fênix A. Hora, Viviane R.S. Jesus, Rafael L.C. Barreto, Breno C. Macambira, Simone G. Soares, Milena Botelho Pereira Meira, Cássio S. Aguiar, Márcio C. Couto, Ricardo. D. Lomonte, Bruno Menezes Filho, José Evaldo Cruz, Jader S. Santos, Marcos A. Vannier Silva, Luciana L. Casais e Silva, Darizy F. |
| author_role |
author |
| author2 |
Alves, Quiara L. Camargo, Samuel B. Araújo, Fênix A. Hora, Viviane R.S. Jesus, Rafael L.C. Barreto, Breno C. Macambira, Simone G. Soares, Milena Botelho Pereira Meira, Cássio S. Aguiar, Márcio C. Couto, Ricardo. D. Lomonte, Bruno Menezes Filho, José Evaldo Cruz, Jader S. Santos, Marcos A. Vannier Silva, Luciana L. Casais e Silva, Darizy F. |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Simões, Letícia O. Alves, Quiara L. Camargo, Samuel B. Araújo, Fênix A. Hora, Viviane R.S. Jesus, Rafael L.C. Barreto, Breno C. Macambira, Simone G. Soares, Milena Botelho Pereira Meira, Cássio S. Aguiar, Márcio C. Couto, Ricardo. D. Lomonte, Bruno Menezes Filho, José Evaldo Cruz, Jader S. Santos, Marcos A. Vannier Silva, Luciana L. Casais e Silva, Darizy F. |
| dc.subject.other.pt_BR.fl_str_mv |
Crotalus Cardiotoxicidade Proliferação de células Mitocôndrias |
| topic |
Crotalus Cardiotoxicidade Proliferação de células Mitocôndrias Crotalus durissus cascavella Cardiotoxicity Atrial |
| dc.subject.en.pt_BR.fl_str_mv |
Crotalus durissus cascavella Cardiotoxicity Atrial |
| description |
Bahia State Research Support Foundation [FAPESB grant number 5198/2014], National Council for Scientific and Technological Development (CNPq) and Coordination for the Improvement of Higher Education Personnel (CAPES) - Finance Code 001. JSC, DFS, MBPS and MAVS are CNPq Research Fellows. |
| publishDate |
2021 |
| dc.date.accessioned.fl_str_mv |
2021-03-16T12:38:21Z |
| dc.date.available.fl_str_mv |
2021-03-16T12:38:21Z |
| dc.date.issued.fl_str_mv |
2021 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
SIMÕES, Letícia O. et al. Cardiac effect induced by Crotalus durissus cascavella venom: Morphofunctional evidence and mechanism of action. Toxicology Letters, v. 337, p. 121–133, 2021. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/46367 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0378-4274 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.toxlet.2020.11.019 |
| identifier_str_mv |
SIMÕES, Letícia O. et al. Cardiac effect induced by Crotalus durissus cascavella venom: Morphofunctional evidence and mechanism of action. Toxicology Letters, v. 337, p. 121–133, 2021. 0378-4274 10.1016/j.toxlet.2020.11.019 |
| url |
https://www.arca.fiocruz.br/handle/icict/46367 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/46367/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/46367/2/Simoes%2c%20Leticia%20O%20Cardiac%20effect....pdf https://www.arca.fiocruz.br/bitstream/icict/46367/3/Simoes%2c%20Leticia%20O%20Cardiac%20effect....pdf.txt |
| bitstream.checksum.fl_str_mv |
36b51ef91c52b5338d9d29ba0cc807bc f3348d80797c5929f5f7de48b493a2c7 65df911d33e85be643543bcbb09dc1f4 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324986016956416 |