Acute paracoccidioidomycosis worsened by immunosuppressive therapy due to a misdiagnosis of Crohn’s disease

Detalhes bibliográficos
Autor(a) principal: Falcão, Eduardo Mastrangelo Marinho
Data de Publicação: 2023
Outros Autores: Medeiros, Manuela da Costa, Freitas, Andrea d´Ávila, Soares, João Carlos de Almeida, Pimentel, Maria Inês Fernandes, Quintella, Leonardo Pereira, Freitas, Dayvison Francis Saraiva, Macedo, Priscila Marques de, Valle, Antônio Carlos Francesconi do
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58413
Resumo: Ethics statement - The Research Ethics Committee of the Evandro Chagas National Institute of Infectious Diseases (INI/FIOCRUZ), a reference center for PCM in Rio de Janeiro State, Brazil approved this study (appreciation number 26066619.0.0000.5262), and a written formal consent was obtained from the patient.
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spelling Falcão, Eduardo Mastrangelo MarinhoMedeiros, Manuela da CostaFreitas, Andrea d´ÁvilaSoares, João Carlos de AlmeidaPimentel, Maria Inês FernandesQuintella, Leonardo PereiraFreitas, Dayvison Francis SaraivaMacedo, Priscila Marques deValle, Antônio Carlos Francesconi do2023-05-16T00:22:41Z2023-05-16T00:22:41Z2023FALCÃO, Eduardo Mastrangelo Marinho et al. Acute paracoccidioidomycosis worsened by immunosuppressive therapy due to a misdiagnosis of Crohn's disease. v. 17, n. 1, p. 1-7, Jan. 2023.1935-2727https://www.arca.fiocruz.br/handle/icict/5841310.1371/journal.pntd.00110231935-2735Ethics statement - The Research Ethics Committee of the Evandro Chagas National Institute of Infectious Diseases (INI/FIOCRUZ), a reference center for PCM in Rio de Janeiro State, Brazil approved this study (appreciation number 26066619.0.0000.5262), and a written formal consent was obtained from the patient.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory on Infectious Dermatology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Department of Inpatient Health Care. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Department of Inpatient Health Care. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Department of Gastroenterology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research and Surveillance on Leishmaniasis. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Anatomical Pathology Service. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory on Infectious Dermatology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory on Infectious Dermatology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory on Infectious Dermatology. Rio de Janeiro, RJ, Brazil.Paracoccidioidomycosis (PCM) is a systemic mycosis endemic in Latin America, mostly in Brazil. The involvement of the gastrointestinal tract is uncommon and usually associated with the acute form. Recently, a cluster of acute PCM cases has been described in Rio de Janeiro, Brazil. We report a 42-year-old male, resident of Rio de Janeiro, presenting chronic diarrhea and abdominal pain in the past 3 years, previously diagnosed as Chron´s disease. When immunosuppressive therapy was prescribed, the patient evolved with worsening of the previous symptoms in addition to odynophagia, 20 kg-weight loss, disseminated skin lesions, diffuse lymphadenopathy and adrenal insufficiency. Histopathological and mycological examination of a skin lesion were compatible with PCM. Itraconazole was prescribed in high doses (400 mg/day). After seven months of treatment, the patient presented with acute abdominal pain which led to an emergent appendectomy, revealing the presence of the fungus. After 24 months, the patient reached clinical cure and recovered from adrenal insufficiency. We emphasize the importance of PCM as a differential diagnosis in patients with chronic diarrhea. The risk of fungal infections should be considered prior to initiating immunosupressive therapies, particularly in endemic areas.engPublic Library of ScienceAcute paracoccidioidomycosis worsened by immunosuppressive therapy due to a misdiagnosis of Crohn’s diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleParacoccidioidomycosisCrohn’s diseaseSystemic mycosisGastrointestinal tractFungal infectionsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58413/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Falcão_Eduardo_etal_INI_2023.pdfve_Falcão_Eduardo_etal_INI_2023.pdfapplication/pdf2133907https://www.arca.fiocruz.br/bitstream/icict/58413/2/ve_Falc%c3%a3o_Eduardo_etal_INI_2023.pdff25adb28033014c7901af8f813fae19fMD52icict/584132023-10-05 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dc.title.en_US.fl_str_mv Acute paracoccidioidomycosis worsened by immunosuppressive therapy due to a misdiagnosis of Crohn’s disease
title Acute paracoccidioidomycosis worsened by immunosuppressive therapy due to a misdiagnosis of Crohn’s disease
spellingShingle Acute paracoccidioidomycosis worsened by immunosuppressive therapy due to a misdiagnosis of Crohn’s disease
Falcão, Eduardo Mastrangelo Marinho
Paracoccidioidomycosis
Crohn’s disease
Systemic mycosis
Gastrointestinal tract
Fungal infections
title_short Acute paracoccidioidomycosis worsened by immunosuppressive therapy due to a misdiagnosis of Crohn’s disease
title_full Acute paracoccidioidomycosis worsened by immunosuppressive therapy due to a misdiagnosis of Crohn’s disease
title_fullStr Acute paracoccidioidomycosis worsened by immunosuppressive therapy due to a misdiagnosis of Crohn’s disease
title_full_unstemmed Acute paracoccidioidomycosis worsened by immunosuppressive therapy due to a misdiagnosis of Crohn’s disease
title_sort Acute paracoccidioidomycosis worsened by immunosuppressive therapy due to a misdiagnosis of Crohn’s disease
author Falcão, Eduardo Mastrangelo Marinho
author_facet Falcão, Eduardo Mastrangelo Marinho
Medeiros, Manuela da Costa
Freitas, Andrea d´Ávila
Soares, João Carlos de Almeida
Pimentel, Maria Inês Fernandes
Quintella, Leonardo Pereira
Freitas, Dayvison Francis Saraiva
Macedo, Priscila Marques de
Valle, Antônio Carlos Francesconi do
author_role author
author2 Medeiros, Manuela da Costa
Freitas, Andrea d´Ávila
Soares, João Carlos de Almeida
Pimentel, Maria Inês Fernandes
Quintella, Leonardo Pereira
Freitas, Dayvison Francis Saraiva
Macedo, Priscila Marques de
Valle, Antônio Carlos Francesconi do
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Falcão, Eduardo Mastrangelo Marinho
Medeiros, Manuela da Costa
Freitas, Andrea d´Ávila
Soares, João Carlos de Almeida
Pimentel, Maria Inês Fernandes
Quintella, Leonardo Pereira
Freitas, Dayvison Francis Saraiva
Macedo, Priscila Marques de
Valle, Antônio Carlos Francesconi do
dc.subject.en.en_US.fl_str_mv Paracoccidioidomycosis
Crohn’s disease
Systemic mycosis
Gastrointestinal tract
Fungal infections
topic Paracoccidioidomycosis
Crohn’s disease
Systemic mycosis
Gastrointestinal tract
Fungal infections
description Ethics statement - The Research Ethics Committee of the Evandro Chagas National Institute of Infectious Diseases (INI/FIOCRUZ), a reference center for PCM in Rio de Janeiro State, Brazil approved this study (appreciation number 26066619.0.0000.5262), and a written formal consent was obtained from the patient.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-05-16T00:22:41Z
dc.date.available.fl_str_mv 2023-05-16T00:22:41Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FALCÃO, Eduardo Mastrangelo Marinho et al. Acute paracoccidioidomycosis worsened by immunosuppressive therapy due to a misdiagnosis of Crohn's disease. v. 17, n. 1, p. 1-7, Jan. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58413
dc.identifier.issn.en_US.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0011023
dc.identifier.eissn.none.fl_str_mv 1935-2735
identifier_str_mv FALCÃO, Eduardo Mastrangelo Marinho et al. Acute paracoccidioidomycosis worsened by immunosuppressive therapy due to a misdiagnosis of Crohn's disease. v. 17, n. 1, p. 1-7, Jan. 2023.
1935-2727
10.1371/journal.pntd.0011023
1935-2735
url https://www.arca.fiocruz.br/handle/icict/58413
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58413/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/58413/2/ve_Falc%c3%a3o_Eduardo_etal_INI_2023.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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