Second-generation pterocarpanquinones: synthesis and antileishmanial activity
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31518 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil. |
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Faiões, Viviane dos SantosFrota, Lívia C. R. M. daCunha Junior, Edézio FerreiraBarcellos, Julio C. F.Silva, Thayssa daDaher Netto, ChaquipSilva, Silvia Amaral Gonçalves daSilva, Alcides J. M. daCosta, Paulo R. R.Santos, Eduardo Caio Torres2019-02-10T18:12:16Z2019-02-10T18:12:16Z2018FAIÕES, Viviane dos Santos et al. Second-generation pterocarpanquinones: synthesis and antileishmanial activity. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, n. 35, p.1-11, 2018,1678-9199https://www.arca.fiocruz.br/handle/icict/3151810.1186/s40409-018-0174-7engBMCLeishmaniaLeishmanioseEnsaio fenotípicoDescoberta da drogaDoenças negligenciadasPterocapanoquinonaLeishmaniaPterocarpanquinoneLQ-118Phenotypic assayLeishmaniasisDrug discoveryNeglected diseasesSecond-generation pterocarpanquinones: synthesis and antileishmanial activityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Pesquisa de Produtos Naturais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Pesquisa de Produtos Naturais. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Laboratório de Imunofarmacologia Parasitária. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Laboratório de Química. Campus Professor Aloísio Teixeira. Macaé, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Laboratório de Imunofarmacologia Parasitária. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Pesquisa de Produtos Naturais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Pesquisa de Produtos Naturais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil.Despite the development of new therapies for leishmaniasis, among the 200 countries or territories reporting to the WHO, 87 were identified as endemic for Tegumentary Leishmaniasis and 75 as endemic for Visceral Leishmaniasis. The identification of antileishmanial drug candidates is essential to fill the drug discovery pipeline for leishmaniasis. In the hit molecule LQB-118 selected, the first generation of pterocarpanquinones was effective and safe against experimental visceral and cutaneous leishmaniasis via oral delivery. In this paper, we report the synthesis and antileishmanial activity of the second generation of pterocarpanoquinones.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31518/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALvivianefaioes_eduardocaio_etal_IOC_2018.pdfvivianefaioes_eduardocaio_etal_IOC_2018.pdfapplication/pdf1090485https://www.arca.fiocruz.br/bitstream/icict/31518/2/vivianefaioes_eduardocaio_etal_IOC_2018.pdfb023f0cefe92f78a28b8462781e06c7aMD52TEXTvivianefaioes_eduardocaio_etal_IOC_2018.pdf.txtvivianefaioes_eduardocaio_etal_IOC_2018.pdf.txtExtracted texttext/plain50554https://www.arca.fiocruz.br/bitstream/icict/31518/3/vivianefaioes_eduardocaio_etal_IOC_2018.pdf.txt2707e4ac93eceb99aa0c85d2d03693e4MD53icict/315182023-09-14 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| dc.title.pt_BR.fl_str_mv |
Second-generation pterocarpanquinones: synthesis and antileishmanial activity |
| title |
Second-generation pterocarpanquinones: synthesis and antileishmanial activity |
| spellingShingle |
Second-generation pterocarpanquinones: synthesis and antileishmanial activity Faiões, Viviane dos Santos Leishmania Leishmaniose Ensaio fenotípico Descoberta da droga Doenças negligenciadas Pterocapanoquinona Leishmania Pterocarpanquinone LQ-118 Phenotypic assay Leishmaniasis Drug discovery Neglected diseases |
| title_short |
Second-generation pterocarpanquinones: synthesis and antileishmanial activity |
| title_full |
Second-generation pterocarpanquinones: synthesis and antileishmanial activity |
| title_fullStr |
Second-generation pterocarpanquinones: synthesis and antileishmanial activity |
| title_full_unstemmed |
Second-generation pterocarpanquinones: synthesis and antileishmanial activity |
| title_sort |
Second-generation pterocarpanquinones: synthesis and antileishmanial activity |
| author |
Faiões, Viviane dos Santos |
| author_facet |
Faiões, Viviane dos Santos Frota, Lívia C. R. M. da Cunha Junior, Edézio Ferreira Barcellos, Julio C. F. Silva, Thayssa da Daher Netto, Chaquip Silva, Silvia Amaral Gonçalves da Silva, Alcides J. M. da Costa, Paulo R. R. Santos, Eduardo Caio Torres |
| author_role |
author |
| author2 |
Frota, Lívia C. R. M. da Cunha Junior, Edézio Ferreira Barcellos, Julio C. F. Silva, Thayssa da Daher Netto, Chaquip Silva, Silvia Amaral Gonçalves da Silva, Alcides J. M. da Costa, Paulo R. R. Santos, Eduardo Caio Torres |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Faiões, Viviane dos Santos Frota, Lívia C. R. M. da Cunha Junior, Edézio Ferreira Barcellos, Julio C. F. Silva, Thayssa da Daher Netto, Chaquip Silva, Silvia Amaral Gonçalves da Silva, Alcides J. M. da Costa, Paulo R. R. Santos, Eduardo Caio Torres |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmania Leishmaniose Ensaio fenotípico Descoberta da droga Doenças negligenciadas Pterocapanoquinona |
| topic |
Leishmania Leishmaniose Ensaio fenotípico Descoberta da droga Doenças negligenciadas Pterocapanoquinona Leishmania Pterocarpanquinone LQ-118 Phenotypic assay Leishmaniasis Drug discovery Neglected diseases |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmania Pterocarpanquinone LQ-118 Phenotypic assay Leishmaniasis Drug discovery Neglected diseases |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil. |
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2018 |
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2018 |
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2019-02-10T18:12:16Z |
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2019-02-10T18:12:16Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
FAIÕES, Viviane dos Santos et al. Second-generation pterocarpanquinones: synthesis and antileishmanial activity. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, n. 35, p.1-11, 2018, |
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https://www.arca.fiocruz.br/handle/icict/31518 |
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1678-9199 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/s40409-018-0174-7 |
| identifier_str_mv |
FAIÕES, Viviane dos Santos et al. Second-generation pterocarpanquinones: synthesis and antileishmanial activity. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, n. 35, p.1-11, 2018, 1678-9199 10.1186/s40409-018-0174-7 |
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