Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins

Detalhes bibliográficos
Autor(a) principal: Ghosh, Anil K.
Data de Publicação: 2009
Outros Autores: Devenport, Martin, Jethwaney, Deepa, Kalume, Dario E., Pandey, Akhilesh, Anderson, Vernon E., Sultan, Ali A., Kumar, Nirbhay, Jacobs-Lorena, Marcelo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27561
Resumo: Johns Hopkins School of Public Health. Malaria Research Institute. Department of Molecular Microbiology and Immunology. Baltimore, Maryland, USA.
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spelling Ghosh, Anil K.Devenport, MartinJethwaney, DeepaKalume, Dario E.Pandey, AkhileshAnderson, Vernon E.Sultan, Ali A.Kumar, NirbhayJacobs-Lorena, Marcelo2018-07-17T13:31:20Z2018-07-17T13:31:20Z2009GHOSH, Anil K. et al. Malaria Parasite Invasion of the Mosquito Salivary Gland Requires Interaction between the Plasmodium TRAP and the Anopheles Saglin Proteins. PLoS Pathog., v.5, n.1, e1000265, 13p,, Jan. 2009.1553-7366https://www.arca.fiocruz.br/handle/icict/2756110.1371/journal.ppat.10002651553-7374engPublic Library of ScienceMaláriaInvasão da ParasitaGlândula salivarMosquitosMalaria parasite invasionMosquito salivary glandAnopheles SaglinPlasmodium TRAPMalaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteinsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleJohns Hopkins School of Public Health. Malaria Research Institute. Department of Molecular Microbiology and Immunology. Baltimore, Maryland, USA.Johns Hopkins School of Public Health. Malaria Research Institute. Department of Molecular Microbiology and Immunology. Baltimore, Maryland, USA.Harvard School of Public Health. Department of Immunology and Infectious Diseases. Boston, Massachussetts, USA.Johns Hopkins School of Medicine. Departments of Biological Chemistry, Pathology, and Oncology. Baltimore, Maryland, USA / McKusick-Nathans Institute of Genetic Medicine. Baltimore, Maryland, USA .Johns Hopkins School of Medicine. Departments of Biological Chemistry, Pathology, and Oncology. Baltimore, Maryland, USA / McKusick-Nathans Institute of Genetic Medicine. Baltimore, Maryland, USA .Case Western Reserve University. Department of Biochemistry. Cleveland, Ohio, USA.Harvard School of Public Health. Department of Immunology and Infectious Diseases. Boston, Massachussetts, USA.Johns Hopkins School of Public Health. Malaria Research Institute. Department of Molecular Microbiology and Immunology. Baltimore, Maryland, USA.Johns Hopkins School of Public Health. Malaria Research Institute. Department of Molecular Microbiology and Immunology. Baltimore, Maryland, USA.SM1 is a twelve-amino-acid peptide that binds tightly to the Anopheles salivary gland and inhibits its invasion by Plasmodium sporozoites. By use of UV-crosslinking experiments between the peptide and its salivary gland target protein, we have identified the Anopheles salivary protein, saglin, as the receptor for SM1. Furthermore, by use of an anti-SM1 antibody, we have determined that the peptide is a mimotope of the Plasmodium sporozoite Thrombospondin Related Anonymous Protein (TRAP). TRAP binds to saglin with high specificity. Point mutations in TRAP's binding domain A abrogate binding, and binding is competed for by the SM1 peptide. Importantly, in vivo down-regulation of saglin expression results in strong inhibition of salivary gland invasion. Together, the results suggest that saglin/TRAP interaction is crucial for salivary gland invasion by Plasmodium sporozoites.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27561/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALDarioE_kalume_etal_IOC_2009.pdfDarioE_kalume_etal_IOC_2009.pdfapplication/pdf1710657https://www.arca.fiocruz.br/bitstream/icict/27561/2/DarioE_kalume_etal_IOC_2009.pdf631cf6c14a0e36d7fa0d18ac11420e39MD52TEXTDarioE_kalume_etal_IOC_2009.pdf.txtDarioE_kalume_etal_IOC_2009.pdf.txtExtracted texttext/plain71951https://www.arca.fiocruz.br/bitstream/icict/27561/3/DarioE_kalume_etal_IOC_2009.pdf.txt206849b4e5ac4184dce0b1568c7c4320MD53icict/275612018-08-15 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dc.title.pt_BR.fl_str_mv Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins
title Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins
spellingShingle Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins
Ghosh, Anil K.
Malária
Invasão da Parasita
Glândula salivar
Mosquitos
Malaria parasite invasion
Mosquito salivary gland
Anopheles Saglin
Plasmodium TRAP
title_short Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins
title_full Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins
title_fullStr Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins
title_full_unstemmed Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins
title_sort Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins
author Ghosh, Anil K.
author_facet Ghosh, Anil K.
Devenport, Martin
Jethwaney, Deepa
Kalume, Dario E.
Pandey, Akhilesh
Anderson, Vernon E.
Sultan, Ali A.
Kumar, Nirbhay
Jacobs-Lorena, Marcelo
author_role author
author2 Devenport, Martin
Jethwaney, Deepa
Kalume, Dario E.
Pandey, Akhilesh
Anderson, Vernon E.
Sultan, Ali A.
Kumar, Nirbhay
Jacobs-Lorena, Marcelo
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ghosh, Anil K.
Devenport, Martin
Jethwaney, Deepa
Kalume, Dario E.
Pandey, Akhilesh
Anderson, Vernon E.
Sultan, Ali A.
Kumar, Nirbhay
Jacobs-Lorena, Marcelo
dc.subject.other.pt_BR.fl_str_mv Malária
Invasão da Parasita
Glândula salivar
Mosquitos
topic Malária
Invasão da Parasita
Glândula salivar
Mosquitos
Malaria parasite invasion
Mosquito salivary gland
Anopheles Saglin
Plasmodium TRAP
dc.subject.en.pt_BR.fl_str_mv Malaria parasite invasion
Mosquito salivary gland
Anopheles Saglin
Plasmodium TRAP
description Johns Hopkins School of Public Health. Malaria Research Institute. Department of Molecular Microbiology and Immunology. Baltimore, Maryland, USA.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2018-07-17T13:31:20Z
dc.date.available.fl_str_mv 2018-07-17T13:31:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GHOSH, Anil K. et al. Malaria Parasite Invasion of the Mosquito Salivary Gland Requires Interaction between the Plasmodium TRAP and the Anopheles Saglin Proteins. PLoS Pathog., v.5, n.1, e1000265, 13p,, Jan. 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27561
dc.identifier.issn.pt_BR.fl_str_mv 1553-7366
dc.identifier.doi.none.fl_str_mv 10.1371/journal.ppat.1000265
dc.identifier.eissn.none.fl_str_mv 1553-7374
identifier_str_mv GHOSH, Anil K. et al. Malaria Parasite Invasion of the Mosquito Salivary Gland Requires Interaction between the Plasmodium TRAP and the Anopheles Saglin Proteins. PLoS Pathog., v.5, n.1, e1000265, 13p,, Jan. 2009.
1553-7366
10.1371/journal.ppat.1000265
1553-7374
url https://www.arca.fiocruz.br/handle/icict/27561
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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