In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae)

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Ana Carolina Borges da Cruz
Data de Publicação: 2019
Outros Autores: Oliveira, Felipe P. de, Dias, Rosane Borges, Sales, Caroline Brandi Schlaepfer, Rocha, Clarissa Araújo Gurgel, Soares, Milena Botelho Pereira, Costa, Emmanoel Vilaça, Silva, Felipe Moura Araujo da, Gomes, Waldireny Rocha, Koolen, Hector Henrique Ferreira, Bezerra, Daniel Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31583
Resumo: Brazilian agencies Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB)
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spelling Rodrigues, Ana Carolina Borges da CruzOliveira, Felipe P. deDias, Rosane BorgesSales, Caroline Brandi SchlaepferRocha, Clarissa Araújo GurgelSoares, Milena Botelho PereiraCosta, Emmanoel VilaçaSilva, Felipe Moura Araujo daGomes, Waldireny RochaKoolen, Hector Henrique FerreiraBezerra, Daniel Pereira2019-02-12T17:15:38Z2019-02-12T17:15:38Z2019RODRIGUES, Ana Carolina Borges da Cruz et al. In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae). Journal of Ethnopharmacology, v. 231, p. 516–524, 2019.0378-8741https://www.arca.fiocruz.br/handle/icict/3158310.1016/j.jep.2018.11.008Brazilian agencies Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB)Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Federal University of Bahia. Institute of Health Sciences. Department of Biomorphology. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, Brazil.Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brazil.Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brazil.Federal University of Amazonas. Health and Biotechnology Institute. Coari, AM, Brazil.Amazonas State University. Metabolomics and Mass Spectrometry Research Group. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Salacia impressifolia (Miers) A. C. Smith (family Celastraceae) is a traditional medicinal plant found in the Amazon Rainforest known as "miraruíra", "cipó-miraruíra" or "panu" and is traditionally used to treat dengue, flu, inflammation, pain, diabetes, male impotency, renal affections, rheumatism and cancer. Aim of the study: The aim of this study was to investigate in vitro and in vivo anti-leukemia activity of the stem bark of S. impressifolia in experimental models. Materials and methods: The in vitro cytotoxic activity of extracts, fractions and quinonemethide triterpenes (22-hydroxytingenone, tingenone and pristimerin) from the stem bark of S. impressifolia in cultured cancer cells was determined. The in vivo antitumor activity of the ethyl acetate extract (EAE) and of its fraction (FEAE.3) from the stem bark of S. impressifolia was assessed in C.B-17 severe combined immunodeficient (SCID) mice engrafted with human promyelocytic leukemia HL-60 cells. Results: The extract EAE, its fraction FEAE.3, and quinonemethide triterpenes exhibited potent cytotoxicity against cancer cell lines, including in vitro anti-leukemia activity against HL-60 and K-562 cells. Moreover, extract EAE and its fraction FEAE.3 inhibited the in vivo development of HL-60 cells engrafted in C.B-17 SCID mice. Tumor mass inhibition rates were measured as 40.4% and 81.5% for the extract EAE (20 mg/kg) and for its fraction FEAE.3 (20 mg/kg), respectively. Conclusions: Ethyl acetate extract and its fraction from the stem bark of S. impressifolia exhibit in vitro and in vivo anti-leukemia activity that can be attributed to their quinonemethide triterpenes. These data confirm the ethnopharmacological use of this species and may contribute to the development of a novel anticancer herbal medicine.engElsevierSalacia impressionifoliaCelastraceaeAnti-leucemiaHL-60Salacia impressifoliaCelastraceaeAnti-leukemiaHL-60In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31583/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRodrigues A.C. In vitro and in vivo anti... 2019.pdfRodrigues A.C. 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dc.title.pt_BR.fl_str_mv In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae)
title In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae)
spellingShingle In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae)
Rodrigues, Ana Carolina Borges da Cruz
Salacia impressionifolia
Celastraceae
Anti-leucemia
HL-60
Salacia impressifolia
Celastraceae
Anti-leukemia
HL-60
title_short In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae)
title_full In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae)
title_fullStr In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae)
title_full_unstemmed In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae)
title_sort In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae)
author Rodrigues, Ana Carolina Borges da Cruz
author_facet Rodrigues, Ana Carolina Borges da Cruz
Oliveira, Felipe P. de
Dias, Rosane Borges
Sales, Caroline Brandi Schlaepfer
Rocha, Clarissa Araújo Gurgel
Soares, Milena Botelho Pereira
Costa, Emmanoel Vilaça
Silva, Felipe Moura Araujo da
Gomes, Waldireny Rocha
Koolen, Hector Henrique Ferreira
Bezerra, Daniel Pereira
author_role author
author2 Oliveira, Felipe P. de
Dias, Rosane Borges
Sales, Caroline Brandi Schlaepfer
Rocha, Clarissa Araújo Gurgel
Soares, Milena Botelho Pereira
Costa, Emmanoel Vilaça
Silva, Felipe Moura Araujo da
Gomes, Waldireny Rocha
Koolen, Hector Henrique Ferreira
Bezerra, Daniel Pereira
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, Ana Carolina Borges da Cruz
Oliveira, Felipe P. de
Dias, Rosane Borges
Sales, Caroline Brandi Schlaepfer
Rocha, Clarissa Araújo Gurgel
Soares, Milena Botelho Pereira
Costa, Emmanoel Vilaça
Silva, Felipe Moura Araujo da
Gomes, Waldireny Rocha
Koolen, Hector Henrique Ferreira
Bezerra, Daniel Pereira
dc.subject.other.pt_BR.fl_str_mv Salacia impressionifolia
Celastraceae
Anti-leucemia
HL-60
topic Salacia impressionifolia
Celastraceae
Anti-leucemia
HL-60
Salacia impressifolia
Celastraceae
Anti-leukemia
HL-60
dc.subject.en.pt_BR.fl_str_mv Salacia impressifolia
Celastraceae
Anti-leukemia
HL-60
description Brazilian agencies Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB)
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-02-12T17:15:38Z
dc.date.available.fl_str_mv 2019-02-12T17:15:38Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RODRIGUES, Ana Carolina Borges da Cruz et al. In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae). Journal of Ethnopharmacology, v. 231, p. 516–524, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31583
dc.identifier.issn.pt_BR.fl_str_mv 0378-8741
dc.identifier.doi.none.fl_str_mv 10.1016/j.jep.2018.11.008
identifier_str_mv RODRIGUES, Ana Carolina Borges da Cruz et al. In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae). Journal of Ethnopharmacology, v. 231, p. 516–524, 2019.
0378-8741
10.1016/j.jep.2018.11.008
url https://www.arca.fiocruz.br/handle/icict/31583
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Elsevier
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