Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/5814 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Lima, Josilene Borges TRibeiro, Guilherme de SousaCordeiro, Soraia MachadoGouveia, Edilane LinsSalgado, Kátia MSpratt, Brian GGodoy, DanielReis, Mitermayer Galvão dosKo, Albert IcksangReis, Joice Neves2012-11-14T19:54:31Z2012-11-14T19:54:31Z2010LIMA, J. B. et al. Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion. Journal of Infectious Diseases, v. 202, n. 10, p. 1577-1584, nov. 2010.1537-6613PMID 20932170https://www.arca.fiocruz.br/handle/icict/581410.1086/656778engPoor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilSecretaria de Saúde do Estado da Bahia. Hospital Couto Maia. Salvador, BA, BrasilImperial College London. Department of Infectious Disease Epidemiology. London, UKFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasilince the introduction of Haemophilus influenzae type b (Hib) conjugate vaccines, meningitis caused by serotypes other than Hib has gained in importance. We conducted active hospital-based surveillance for meningitis over an 11-year period in Salvador, Brazil. H. influenzae isolates were serotyped and analyzed by polymerase chain reaction, pulsed-field gel electrophoresis, and DNA sequencing to identify strains with a specific deletion (IS1016) in the bexA gene (IS1016-bexA). We identified 43 meningitis cases caused by non-type b H. influenzae: 28 (65%) were caused by type a (Hia), 9 (21%) were caused by noncapsulated strains, and 3 (7%) each were caused by types e and f. Hia isolates clustered in 2 clonal groups; clonal group A strains (n = 9) had the IS1016-bexA deletion. Among children <5 years of age, meningitis caused by Hia from clonal group A had higher case-fatality than meningitis caused by clonal group B. Despite small numbers, these results indicate that the presence of the IS1016-bexA deletion is associated with enhanced virulence in non-type b H. influenzae.Haemophilus influenzaenon-type b H. influenzaeMeningitisHib conjugate vaccineVirulenceIS1016-bexA deletionMolecular epidemiologyTransportadores de Cassetes de Ligação de ATP/genéticaProteínas de Bactérias/genéticaHaemophilus/genéticaMeningite por HaemophilusVirulencia/genéticainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALLima Josilene et al.pdfLima Josilene et al.pdfapplication/pdf1281768https://www.arca.fiocruz.br/bitstream/icict/5814/1/Lima%20Josilene%20et%20al.pdf8f3d780dd2627af3074616cd65ffd73eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5814/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTLima Josilene et al.pdf.txtLima Josilene et al.pdf.txtExtracted texttext/plain38825https://www.arca.fiocruz.br/bitstream/icict/5814/5/Lima%20Josilene%20et%20al.pdf.txt05be078e5848be3efcd40f954a90d24bMD55THUMBNAILLima Josilene et al.pdf.jpgLima Josilene et al.pdf.jpgGenerated Thumbnailimage/jpeg2351https://www.arca.fiocruz.br/bitstream/icict/5814/4/Lima%20Josilene%20et%20al.pdf.jpgdfad7313a4373932fa4ef669f70a15d0MD54icict/58142023-03-15 14:32:58.259oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion |
| title |
Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion |
| spellingShingle |
Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion Lima, Josilene Borges T Haemophilus influenzae non-type b H. influenzae Meningitis Hib conjugate vaccine Virulence IS1016-bexA deletion Molecular epidemiology Transportadores de Cassetes de Ligação de ATP/genética Proteínas de Bactérias/genética Haemophilus/genética Meningite por Haemophilus Virulencia/genética |
| title_short |
Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion |
| title_full |
Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion |
| title_fullStr |
Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion |
| title_full_unstemmed |
Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion |
| title_sort |
Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion |
| author |
Lima, Josilene Borges T |
| author_facet |
Lima, Josilene Borges T Ribeiro, Guilherme de Sousa Cordeiro, Soraia Machado Gouveia, Edilane Lins Salgado, Kátia M Spratt, Brian G Godoy, Daniel Reis, Mitermayer Galvão dos Ko, Albert Icksang Reis, Joice Neves |
| author_role |
author |
| author2 |
Ribeiro, Guilherme de Sousa Cordeiro, Soraia Machado Gouveia, Edilane Lins Salgado, Kátia M Spratt, Brian G Godoy, Daniel Reis, Mitermayer Galvão dos Ko, Albert Icksang Reis, Joice Neves |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lima, Josilene Borges T Ribeiro, Guilherme de Sousa Cordeiro, Soraia Machado Gouveia, Edilane Lins Salgado, Kátia M Spratt, Brian G Godoy, Daniel Reis, Mitermayer Galvão dos Ko, Albert Icksang Reis, Joice Neves |
| dc.subject.en.pt_BR.fl_str_mv |
Haemophilus influenzae non-type b H. influenzae Meningitis Hib conjugate vaccine Virulence IS1016-bexA deletion Molecular epidemiology |
| topic |
Haemophilus influenzae non-type b H. influenzae Meningitis Hib conjugate vaccine Virulence IS1016-bexA deletion Molecular epidemiology Transportadores de Cassetes de Ligação de ATP/genética Proteínas de Bactérias/genética Haemophilus/genética Meningite por Haemophilus Virulencia/genética |
| dc.subject.decs.pt_BR.fl_str_mv |
Transportadores de Cassetes de Ligação de ATP/genética Proteínas de Bactérias/genética Haemophilus/genética Meningite por Haemophilus Virulencia/genética |
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Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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2010 |
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2010 |
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2012-11-14T19:54:31Z |
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2012-11-14T19:54:31Z |
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LIMA, J. B. et al. Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion. Journal of Infectious Diseases, v. 202, n. 10, p. 1577-1584, nov. 2010. |
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https://www.arca.fiocruz.br/handle/icict/5814 |
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1537-6613 |
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PMID 20932170 |
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10.1086/656778 |
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LIMA, J. B. et al. Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion. Journal of Infectious Diseases, v. 202, n. 10, p. 1577-1584, nov. 2010. 1537-6613 PMID 20932170 10.1086/656778 |
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