Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion

Detalhes bibliográficos
Autor(a) principal: Lima, Josilene Borges T
Data de Publicação: 2010
Outros Autores: Ribeiro, Guilherme de Sousa, Cordeiro, Soraia Machado, Gouveia, Edilane Lins, Salgado, Kátia M, Spratt, Brian G, Godoy, Daniel, Reis, Mitermayer Galvão dos, Ko, Albert Icksang, Reis, Joice Neves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5814
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Lima, Josilene Borges TRibeiro, Guilherme de SousaCordeiro, Soraia MachadoGouveia, Edilane LinsSalgado, Kátia MSpratt, Brian GGodoy, DanielReis, Mitermayer Galvão dosKo, Albert IcksangReis, Joice Neves2012-11-14T19:54:31Z2012-11-14T19:54:31Z2010LIMA, J. B. et al. Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion. Journal of Infectious Diseases, v. 202, n. 10, p. 1577-1584, nov. 2010.1537-6613PMID 20932170https://www.arca.fiocruz.br/handle/icict/581410.1086/656778engPoor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilSecretaria de Saúde do Estado da Bahia. Hospital Couto Maia. Salvador, BA, BrasilImperial College London. Department of Infectious Disease Epidemiology. London, UKFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasilince the introduction of Haemophilus influenzae type b (Hib) conjugate vaccines, meningitis caused by serotypes other than Hib has gained in importance. We conducted active hospital-based surveillance for meningitis over an 11-year period in Salvador, Brazil. H. influenzae isolates were serotyped and analyzed by polymerase chain reaction, pulsed-field gel electrophoresis, and DNA sequencing to identify strains with a specific deletion (IS1016) in the bexA gene (IS1016-bexA). We identified 43 meningitis cases caused by non-type b H. influenzae: 28 (65%) were caused by type a (Hia), 9 (21%) were caused by noncapsulated strains, and 3 (7%) each were caused by types e and f. Hia isolates clustered in 2 clonal groups; clonal group A strains (n = 9) had the IS1016-bexA deletion. Among children <5 years of age, meningitis caused by Hia from clonal group A had higher case-fatality than meningitis caused by clonal group B. Despite small numbers, these results indicate that the presence of the IS1016-bexA deletion is associated with enhanced virulence in non-type b H. influenzae.Haemophilus influenzaenon-type b H. influenzaeMeningitisHib conjugate vaccineVirulenceIS1016-bexA deletionMolecular epidemiologyTransportadores de Cassetes de Ligação de ATP/genéticaProteínas de Bactérias/genéticaHaemophilus/genéticaMeningite por HaemophilusVirulencia/genéticainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALLima Josilene et al.pdfLima Josilene et al.pdfapplication/pdf1281768https://www.arca.fiocruz.br/bitstream/icict/5814/1/Lima%20Josilene%20et%20al.pdf8f3d780dd2627af3074616cd65ffd73eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5814/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTLima Josilene et al.pdf.txtLima Josilene et al.pdf.txtExtracted texttext/plain38825https://www.arca.fiocruz.br/bitstream/icict/5814/5/Lima%20Josilene%20et%20al.pdf.txt05be078e5848be3efcd40f954a90d24bMD55THUMBNAILLima Josilene et al.pdf.jpgLima Josilene et al.pdf.jpgGenerated Thumbnailimage/jpeg2351https://www.arca.fiocruz.br/bitstream/icict/5814/4/Lima%20Josilene%20et%20al.pdf.jpgdfad7313a4373932fa4ef669f70a15d0MD54icict/58142023-03-15 14:32:58.259oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
title Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
spellingShingle Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
Lima, Josilene Borges T
Haemophilus influenzae
non-type b H. influenzae
Meningitis
Hib conjugate vaccine
Virulence
IS1016-bexA deletion
Molecular epidemiology
Transportadores de Cassetes de Ligação de ATP/genética
Proteínas de Bactérias/genética
Haemophilus/genética
Meningite por Haemophilus
Virulencia/genética
title_short Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
title_full Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
title_fullStr Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
title_full_unstemmed Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
title_sort Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
author Lima, Josilene Borges T
author_facet Lima, Josilene Borges T
Ribeiro, Guilherme de Sousa
Cordeiro, Soraia Machado
Gouveia, Edilane Lins
Salgado, Kátia M
Spratt, Brian G
Godoy, Daniel
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Reis, Joice Neves
author_role author
author2 Ribeiro, Guilherme de Sousa
Cordeiro, Soraia Machado
Gouveia, Edilane Lins
Salgado, Kátia M
Spratt, Brian G
Godoy, Daniel
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Reis, Joice Neves
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Josilene Borges T
Ribeiro, Guilherme de Sousa
Cordeiro, Soraia Machado
Gouveia, Edilane Lins
Salgado, Kátia M
Spratt, Brian G
Godoy, Daniel
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Reis, Joice Neves
dc.subject.en.pt_BR.fl_str_mv Haemophilus influenzae
non-type b H. influenzae
Meningitis
Hib conjugate vaccine
Virulence
IS1016-bexA deletion
Molecular epidemiology
topic Haemophilus influenzae
non-type b H. influenzae
Meningitis
Hib conjugate vaccine
Virulence
IS1016-bexA deletion
Molecular epidemiology
Transportadores de Cassetes de Ligação de ATP/genética
Proteínas de Bactérias/genética
Haemophilus/genética
Meningite por Haemophilus
Virulencia/genética
dc.subject.decs.pt_BR.fl_str_mv Transportadores de Cassetes de Ligação de ATP/genética
Proteínas de Bactérias/genética
Haemophilus/genética
Meningite por Haemophilus
Virulencia/genética
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2012-11-14T19:54:31Z
dc.date.available.fl_str_mv 2012-11-14T19:54:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv LIMA, J. B. et al. Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion. Journal of Infectious Diseases, v. 202, n. 10, p. 1577-1584, nov. 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5814
dc.identifier.issn.none.fl_str_mv 1537-6613
dc.identifier.other.none.fl_str_mv PMID 20932170
dc.identifier.doi.none.fl_str_mv 10.1086/656778
identifier_str_mv LIMA, J. B. et al. Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion. Journal of Infectious Diseases, v. 202, n. 10, p. 1577-1584, nov. 2010.
1537-6613
PMID 20932170
10.1086/656778
url https://www.arca.fiocruz.br/handle/icict/5814
dc.language.iso.fl_str_mv eng
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