Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/9289 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brasil |
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Assis, Tália Santana Machado deBraga, Alexandre Sérgio da CostaPedras, Mariana JunqueiraOliveira, Edward José deBarral, Aldina Maria PradoSiqueira, Isadora Cristina deCosta, Carlos Henrique NeryCosta, Dorcas LamounierHolanda, Thiago AyresSoares, Vítor Yamashiro RochaSilva, Mauro Roberto Biá daCaldas, Arlene de Jesus MendesRomero, Gustavo Adolfo SierraRabello, Ana Lúcia Teles2014-12-23T16:53:44Z2014-12-23T16:53:44Z2011ASSIS, T. S. M. et al. Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 105, n. 2, p. 81-85, 2011.1878-3503https://www.arca.fiocruz.br/handle/icict/928910.1016/j.trstmh.2010.09.004engOxford University PressMulti-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital da Criança. Obras Sociais de Irmã Dulce. Salvador, BA, BrasilUniversidade Federal do Piauí. Teresina, PI, BrasilUniversidade Federal do Piauí. Teresina, PI, BrasilUniversidade Federal do Piauí. Teresina, PI, BrasilUniversidade Federal do Piauí. Teresina, PI, BrasilUniversidade Federal do Piauí. Teresina, PI, BrasilUniversidade Federal do Maranhão. São Luís, MA, BrasilUniversidade de Brasília. Brasília, DF, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, BrasilThe diagnosis of visceral leishmaniasis (VL) is still a major problem in Brazil and several other countries where the disease is endemic. The use of an easy-to-use and interpret, sensitive, and specific method that requires no complex infrastructure or specialized professionals, such as direct agglutination test (DAT) and the rK39-based rapid immunochromatographic test may enhance the diagnosis of disease. This study evaluated the performance of a rapid test (DiaMed- IT-LEISH®) and the DAT for the diagnosis of VL in 213 parasitologically confirmed cases and 119 controls with clinical suspicion of VL and confirmation of another etiology. The sensitivities and specificities of the rapid test were 93% and 97%, respectively and those of the DAT were 90% and 96%, respectively. The positive predictive values of the rapid test and the DAT were 98% and 97%, respectively and the negative predictive values were 89% and 84%, respectively. The Kappa index showed agreement between both methods classified as substantial (0.77). This study showed that the DAT and the rapid test can be used to diagnose VL in Brazil, following a pilot study for implementation of the rapid test in the health servicesDirect agglutination testRapid test rK39Visceral leishmaniasisSensitivitySpecificity and diagnostic accuracyTestes de Aglutinação/normasLeishmaniose Visceral/diagnósticoKit de Reagentes para DiagnósticoAnimaisBrasil/epidemiologiaFemininoHumanosMasculinoPrevalênciaLeishmaniose Visceral/epidemiologiaEstudos ProspectivosPadrões de ReferênciaSensibilidade e Especificidadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9289/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALAssis T S M Multi-centric prospective....pdfAssis T S M Multi-centric prospective....pdfapplication/pdf138158https://www.arca.fiocruz.br/bitstream/icict/9289/2/Assis%20T%20S%20M%20Multi-centric%20prospective....pdfb2acfec87df42a7da4cebe03cc315af3MD52TEXTAssis T S M Multi-centric prospective....pdf.txtAssis T S M Multi-centric prospective....pdf.txtExtracted texttext/plain26036https://www.arca.fiocruz.br/bitstream/icict/9289/3/Assis%20T%20S%20M%20Multi-centric%20prospective....pdf.txt3ca1236f6997751491143309af27307eMD53icict/92892023-03-15 14:32:53.503oai:www.arca.fiocruz.br:icict/9289TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:53Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil |
title |
Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil |
spellingShingle |
Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil Assis, Tália Santana Machado de Direct agglutination test Rapid test rK39 Visceral leishmaniasis Sensitivity Specificity and diagnostic accuracy Testes de Aglutinação/normas Leishmaniose Visceral/diagnóstico Kit de Reagentes para Diagnóstico Animais Brasil/epidemiologia Feminino Humanos Masculino Prevalência Leishmaniose Visceral/epidemiologia Estudos Prospectivos Padrões de Referência Sensibilidade e Especificidade |
title_short |
Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil |
title_full |
Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil |
title_fullStr |
Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil |
title_full_unstemmed |
Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil |
title_sort |
Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil |
author |
Assis, Tália Santana Machado de |
author_facet |
Assis, Tália Santana Machado de Braga, Alexandre Sérgio da Costa Pedras, Mariana Junqueira Oliveira, Edward José de Barral, Aldina Maria Prado Siqueira, Isadora Cristina de Costa, Carlos Henrique Nery Costa, Dorcas Lamounier Holanda, Thiago Ayres Soares, Vítor Yamashiro Rocha Silva, Mauro Roberto Biá da Caldas, Arlene de Jesus Mendes Romero, Gustavo Adolfo Sierra Rabello, Ana Lúcia Teles |
author_role |
author |
author2 |
Braga, Alexandre Sérgio da Costa Pedras, Mariana Junqueira Oliveira, Edward José de Barral, Aldina Maria Prado Siqueira, Isadora Cristina de Costa, Carlos Henrique Nery Costa, Dorcas Lamounier Holanda, Thiago Ayres Soares, Vítor Yamashiro Rocha Silva, Mauro Roberto Biá da Caldas, Arlene de Jesus Mendes Romero, Gustavo Adolfo Sierra Rabello, Ana Lúcia Teles |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Assis, Tália Santana Machado de Braga, Alexandre Sérgio da Costa Pedras, Mariana Junqueira Oliveira, Edward José de Barral, Aldina Maria Prado Siqueira, Isadora Cristina de Costa, Carlos Henrique Nery Costa, Dorcas Lamounier Holanda, Thiago Ayres Soares, Vítor Yamashiro Rocha Silva, Mauro Roberto Biá da Caldas, Arlene de Jesus Mendes Romero, Gustavo Adolfo Sierra Rabello, Ana Lúcia Teles |
dc.subject.en.pt_BR.fl_str_mv |
Direct agglutination test Rapid test rK39 Visceral leishmaniasis Sensitivity Specificity and diagnostic accuracy |
topic |
Direct agglutination test Rapid test rK39 Visceral leishmaniasis Sensitivity Specificity and diagnostic accuracy Testes de Aglutinação/normas Leishmaniose Visceral/diagnóstico Kit de Reagentes para Diagnóstico Animais Brasil/epidemiologia Feminino Humanos Masculino Prevalência Leishmaniose Visceral/epidemiologia Estudos Prospectivos Padrões de Referência Sensibilidade e Especificidade |
dc.subject.decs.pt_BR.fl_str_mv |
Testes de Aglutinação/normas Leishmaniose Visceral/diagnóstico Kit de Reagentes para Diagnóstico Animais Brasil/epidemiologia Feminino Humanos Masculino Prevalência Leishmaniose Visceral/epidemiologia Estudos Prospectivos Padrões de Referência Sensibilidade e Especificidade |
description |
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brasil |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2014-12-23T16:53:44Z |
dc.date.available.fl_str_mv |
2014-12-23T16:53:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ASSIS, T. S. M. et al. Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 105, n. 2, p. 81-85, 2011. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/9289 |
dc.identifier.issn.none.fl_str_mv |
1878-3503 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.trstmh.2010.09.004 |
identifier_str_mv |
ASSIS, T. S. M. et al. Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 105, n. 2, p. 81-85, 2011. 1878-3503 10.1016/j.trstmh.2010.09.004 |
url |
https://www.arca.fiocruz.br/handle/icict/9289 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
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