Pro-cellular exhaustion markers are associated with splenic microarchitecture disorganization and parasite load in dogs with visceral leishmaniasis
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36107 |
Resumo: | 2020-04-02 |
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Souza, Tainã Luís deSilva, Aurea Virginia Andrade daPereira, Luiza de Oliveira RamosFigueiredo, Fabiano BorgesMendes Junior, Artur Augusto VelhoMenezes, Rodrigo CaldasMendes-da-Cruz, Daniella A.Boité, Mariana CôrtesCupolillo, ElisaPorrozzi, RenatoMorgado, Fernanda Nazaré2019-10-03T12:02:58Z2019-10-03T12:02:58Z2019SOUZA, Tainã Luís de et al. Pro-cellular exhaustion markers are associated with splenic microarchitecture disorganization and parasite load in dogs with visceral leishmaniasis. Nature, v. 9, p. 1-14, 2019.0028-0836https://www.arca.fiocruz.br/handle/icict/3610710.1038/s41598-019-49344-11476-4687eng0028-0836Pro-cellular exhaustion markers are associated with splenic microarchitecture disorganization and parasite load in dogs with visceral leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-04-02Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Celular. Paraná, PR, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas Sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose Rio de Janeiro. Rio de Janeiro, RJ, Brasil.In canine visceral leishmaniasis (CVL), splenic white pulp (SWP) disorganization has been associated with disease progression, reduced cytokine and chemokine expression and failure to control the parasite load. This profile is compatible with the cellular exhaustion previously shown in human visceral leishmaniasis. The present study aimed to evaluate the in situ expression of cellular exhaustion markers and their relation to clinical signs, SWP disorganization and parasite load. Forty dogs naturally infected by Leishmania infantum were grouped according to levels of SWP organization and parasite load. SWP disorganization was associated with reductions in the periarteriolar lymphatic sheath and lymphoid follicles/mm2 and worsening of the disease. Apoptotic cells expressing CTLA-4+ increased in dogs with disorganized SWP and a high parasite load. In the same group, PD-L1 and LAG-3 gene expression were reduced. A higher number of CD21+TIM-3+ B cells was detected in disorganized spleens than in organized spleens. Apoptosis is involved in periarteriolar lymphatic sheath reduction and lymphoid follicle atrophy and is associated with CTLA-4+ cell reductions in the splenic tissue of dogs with visceral leishmaniasis (VL). Failure to control the parasite load was observed, suggesting that cell exhaustion followed by T and B cell apoptosis plays a role in the immunosuppression observed in CVL.Canine visceral leishmaniasisLeishmania infantumDogsSplenic white pulpinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/36107/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Souza_Tainã_etal_INI_2019.pdfve_Souza_Tainã_etal_INI_2019.pdfapplication/pdf8741281https://www.arca.fiocruz.br/bitstream/icict/36107/2/ve_Souza_Tain%c3%a3_etal_INI_2019.pdfeae9bb248479a1454b6bb5341b535ac4MD52TEXTve_Souza_Tainã_etal_INI_2019.pdf.txtve_Souza_Tainã_etal_INI_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Pro-cellular exhaustion markers are associated with splenic microarchitecture disorganization and parasite load in dogs with visceral leishmaniasis |
title |
Pro-cellular exhaustion markers are associated with splenic microarchitecture disorganization and parasite load in dogs with visceral leishmaniasis |
spellingShingle |
Pro-cellular exhaustion markers are associated with splenic microarchitecture disorganization and parasite load in dogs with visceral leishmaniasis Souza, Tainã Luís de Canine visceral leishmaniasis Leishmania infantum Dogs Splenic white pulp |
title_short |
Pro-cellular exhaustion markers are associated with splenic microarchitecture disorganization and parasite load in dogs with visceral leishmaniasis |
title_full |
Pro-cellular exhaustion markers are associated with splenic microarchitecture disorganization and parasite load in dogs with visceral leishmaniasis |
title_fullStr |
Pro-cellular exhaustion markers are associated with splenic microarchitecture disorganization and parasite load in dogs with visceral leishmaniasis |
title_full_unstemmed |
Pro-cellular exhaustion markers are associated with splenic microarchitecture disorganization and parasite load in dogs with visceral leishmaniasis |
title_sort |
Pro-cellular exhaustion markers are associated with splenic microarchitecture disorganization and parasite load in dogs with visceral leishmaniasis |
author |
Souza, Tainã Luís de |
author_facet |
Souza, Tainã Luís de Silva, Aurea Virginia Andrade da Pereira, Luiza de Oliveira Ramos Figueiredo, Fabiano Borges Mendes Junior, Artur Augusto Velho Menezes, Rodrigo Caldas Mendes-da-Cruz, Daniella A. Boité, Mariana Côrtes Cupolillo, Elisa Porrozzi, Renato Morgado, Fernanda Nazaré |
author_role |
author |
author2 |
Silva, Aurea Virginia Andrade da Pereira, Luiza de Oliveira Ramos Figueiredo, Fabiano Borges Mendes Junior, Artur Augusto Velho Menezes, Rodrigo Caldas Mendes-da-Cruz, Daniella A. Boité, Mariana Côrtes Cupolillo, Elisa Porrozzi, Renato Morgado, Fernanda Nazaré |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Souza, Tainã Luís de Silva, Aurea Virginia Andrade da Pereira, Luiza de Oliveira Ramos Figueiredo, Fabiano Borges Mendes Junior, Artur Augusto Velho Menezes, Rodrigo Caldas Mendes-da-Cruz, Daniella A. Boité, Mariana Côrtes Cupolillo, Elisa Porrozzi, Renato Morgado, Fernanda Nazaré |
dc.subject.en.pt_BR.fl_str_mv |
Canine visceral leishmaniasis Leishmania infantum Dogs Splenic white pulp |
topic |
Canine visceral leishmaniasis Leishmania infantum Dogs Splenic white pulp |
description |
2020-04-02 |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-10-03T12:02:58Z |
dc.date.available.fl_str_mv |
2019-10-03T12:02:58Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SOUZA, Tainã Luís de et al. Pro-cellular exhaustion markers are associated with splenic microarchitecture disorganization and parasite load in dogs with visceral leishmaniasis. Nature, v. 9, p. 1-14, 2019. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/36107 |
dc.identifier.issn.pt_BR.fl_str_mv |
0028-0836 |
dc.identifier.doi.none.fl_str_mv |
10.1038/s41598-019-49344-1 |
dc.identifier.eissn.none.fl_str_mv |
1476-4687 |
identifier_str_mv |
SOUZA, Tainã Luís de et al. Pro-cellular exhaustion markers are associated with splenic microarchitecture disorganization and parasite load in dogs with visceral leishmaniasis. Nature, v. 9, p. 1-14, 2019. 0028-0836 10.1038/s41598-019-49344-1 1476-4687 |
url |
https://www.arca.fiocruz.br/handle/icict/36107 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
0028-0836 |
publisher.none.fl_str_mv |
0028-0836 |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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