Is the mitochondrion a promising drug target in trypanosomatids?

Detalhes bibliográficos
Autor(a) principal: Rezende, Yasmin Pedra
Data de Publicação: 2022
Outros Autores: Bombaça, Ana Cristina Souza, Menna-Barreto, Rubem Figueiredo Sadok
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51350
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
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spelling Rezende, Yasmin PedraBombaça, Ana Cristina SouzaMenna-Barreto, Rubem Figueiredo Sadok2022-02-21T19:35:42Z2022-02-21T19:35:42Z2022REZENDE, Yasmin Pedra; BOMBAÇA. Ana Cristina; MENNA-BARRETO, Rubem Figueiredo Sadok. Is the mitochondrion a promising drug target in trypanosomatids? Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, e210379, p. 1-9, 2022.0074-0206https://www.arca.fiocruz.br/handle/icict/5135010.1590/0074-027602103791678-8060engFiocruz/IOCTripanossomatídeosMitocôndriaEstresse oxidativoQuimioteraiaImportação de proteínas mitocondriaisBioenergéticaTrypanosomatidsMitochondrionOxidative stressChemotherapyMitochondrial protein importBioenergeticsIs the mitochondrion a promising drug target in trypanosomatids?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.The trypanosomatids Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are etiological agents of important neglected tropical diseases, affecting millions of people worldwide, and the drugs available for these diseases present several limitations. Novel efficient and nontoxic drugs are necessary as an alternative to the current chemotherapy. The unique mitochondrion of trypanosomatids and its peculiar features turn this organelle a potential drug target. Several phenotypic studies describe the damage in the parasite mitochondrial ultrastructure, but the molecular target is unknown. Few reports demonstrated the electron transport system (ETS) as a target due to the high similarities to mammalian orthologues, hence ETS is not a good candidate for drug intervention. On the other hand, antioxidant enzymes, such as trypanothione reductase, and an alternative oxidase (AOX) seem to be interesting targets; however no high active inhibitors were developed up to now. Finally, due to the remarkable differences to mammalian machinery, together with the high biological importance for the parasite survival, the mitochondrial import system stands out as a very promising target in trypanosomatids. Archaic translocase of the outer membrane (ATOM) and translocase of the inner membrane (TIM) complexes, which mediate both protein and tRNA import, composed by specific subunits of these parasites, could be excellent candidates, deserving studies focused on the development of specific drugs.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51350/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALYasminRezende_RubemFDMennaBarreto_AnaBombaça_IOC_2022.pdfYasminRezende_RubemFDMennaBarreto_AnaBombaça_IOC_2022.pdfapplication/pdf950152https://www.arca.fiocruz.br/bitstream/icict/51350/2/YasminRezende_RubemFDMennaBarreto_AnaBomba%c3%a7a_IOC_2022.pdf0009b88d0add7c0339560eb9419b5389MD52icict/513502023-09-05 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dc.title.pt_BR.fl_str_mv Is the mitochondrion a promising drug target in trypanosomatids?
title Is the mitochondrion a promising drug target in trypanosomatids?
spellingShingle Is the mitochondrion a promising drug target in trypanosomatids?
Rezende, Yasmin Pedra
Tripanossomatídeos
Mitocôndria
Estresse oxidativo
Quimioteraia
Importação de proteínas mitocondriais
Bioenergética
Trypanosomatids
Mitochondrion
Oxidative stress
Chemotherapy
Mitochondrial protein import
Bioenergetics
title_short Is the mitochondrion a promising drug target in trypanosomatids?
title_full Is the mitochondrion a promising drug target in trypanosomatids?
title_fullStr Is the mitochondrion a promising drug target in trypanosomatids?
title_full_unstemmed Is the mitochondrion a promising drug target in trypanosomatids?
title_sort Is the mitochondrion a promising drug target in trypanosomatids?
author Rezende, Yasmin Pedra
author_facet Rezende, Yasmin Pedra
Bombaça, Ana Cristina Souza
Menna-Barreto, Rubem Figueiredo Sadok
author_role author
author2 Bombaça, Ana Cristina Souza
Menna-Barreto, Rubem Figueiredo Sadok
author2_role author
author
dc.contributor.author.fl_str_mv Rezende, Yasmin Pedra
Bombaça, Ana Cristina Souza
Menna-Barreto, Rubem Figueiredo Sadok
dc.subject.other.pt_BR.fl_str_mv Tripanossomatídeos
Mitocôndria
Estresse oxidativo
Quimioteraia
Importação de proteínas mitocondriais
Bioenergética
topic Tripanossomatídeos
Mitocôndria
Estresse oxidativo
Quimioteraia
Importação de proteínas mitocondriais
Bioenergética
Trypanosomatids
Mitochondrion
Oxidative stress
Chemotherapy
Mitochondrial protein import
Bioenergetics
dc.subject.en.pt_BR.fl_str_mv Trypanosomatids
Mitochondrion
Oxidative stress
Chemotherapy
Mitochondrial protein import
Bioenergetics
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-02-21T19:35:42Z
dc.date.available.fl_str_mv 2022-02-21T19:35:42Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv REZENDE, Yasmin Pedra; BOMBAÇA. Ana Cristina; MENNA-BARRETO, Rubem Figueiredo Sadok. Is the mitochondrion a promising drug target in trypanosomatids? Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, e210379, p. 1-9, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51350
dc.identifier.issn.pt_BR.fl_str_mv 0074-0206
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760210379
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv REZENDE, Yasmin Pedra; BOMBAÇA. Ana Cristina; MENNA-BARRETO, Rubem Figueiredo Sadok. Is the mitochondrion a promising drug target in trypanosomatids? Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, e210379, p. 1-9, 2022.
0074-0206
10.1590/0074-02760210379
1678-8060
url https://www.arca.fiocruz.br/handle/icict/51350
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz/IOC
publisher.none.fl_str_mv Fiocruz/IOC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51350/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51350/2/YasminRezende_RubemFDMennaBarreto_AnaBomba%c3%a7a_IOC_2022.pdf
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