PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23013 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil / Universidade Federal de Juiz de Fora. Laboratório de Biologia Celular. Juiz de Fora, MG, Brasil. |
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Almeida, Patricia E.Carneiro, Alan BritoSilva, Adriana R.Bozza, Patrícia T.2017-11-01T10:42:53Z2017-11-01T10:42:53Z2012ALMEIDA, Patricia E. et al. PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing. PPAR Research, volume 2012, Article ID 383829, 7p, 2012.1687-4757https://www.arca.fiocruz.br/handle/icict/2301310.1155/2012/3838291687-4765engHindawi Publishing CorporationReceptores Ativados por Proliferador de PeroxissomoInfecções por MicobactériaMetabolismo dos LipídeosImunidadePPARγMycobacterial InfectionLipid metabolismImmunityPPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killinginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil / Universidade Federal de Juiz de Fora. Laboratório de Biologia Celular. Juiz de Fora, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil..Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Tuberculosis continues to be a global health threat, with drug resistance and HIV coinfection presenting challenges for its control. Mycobacterium tuberculosis, the etiological agent of tuberculosis, is a highly adapted pathogen that has evolved different strategies to subvert the immune and metabolic responses of host cells. Although the significance of peroxisome proliferator-activated receptor gamma (PPARγ) activation by mycobacteria is not fully understood, recent findings are beginning to uncover a critical role for PPARγ during mycobacterial infection. Here, we will review the molecular mechanisms that regulate PPARγ expression and function during mycobacterial infection. Current evidence indicates that mycobacterial infection causes a time-dependent increase in PPARγ expression through mechanisms that involve pattern recognition receptor activation. Mycobacterial triggered increased PPARγ expression and activation lead to increased lipid droplet formation and downmodulation of macrophage response, suggesting that PPARγ expression might aid the mycobacteria in circumventing the host response acting as an escape mechanism. Indeed, inhibition of PPARγ enhances mycobacterial killing capacity of macrophages, suggesting a role of PPARγ in favoring the establishment of chronic infection. Collectively, PPARγ is emerging as a regulator of tuberculosis pathogenesis and an attractive target for the development of adjunctive tuberculosis therapies.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23013/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALpatricia_almeida_etal_IOC.2012.pdfpatricia_almeida_etal_IOC.2012.pdfapplication/pdf2583100https://www.arca.fiocruz.br/bitstream/icict/23013/2/patricia_almeida_etal_IOC.2012.pdf9dcba704014ba449eabbd9a4d08cf0abMD52TEXTpatricia_almeida_etal_IOC.2012.pdf.txtpatricia_almeida_etal_IOC.2012.pdf.txtExtracted texttext/plain42450https://www.arca.fiocruz.br/bitstream/icict/23013/3/patricia_almeida_etal_IOC.2012.pdf.txt7a03122635a57fac770c75c1c7c3a33aMD53icict/230132022-06-24 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| dc.title.pt_BR.fl_str_mv |
PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing |
| title |
PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing |
| spellingShingle |
PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing Almeida, Patricia E. Receptores Ativados por Proliferador de Peroxissomo Infecções por Micobactéria Metabolismo dos Lipídeos Imunidade PPARγ Mycobacterial Infection Lipid metabolism Immunity |
| title_short |
PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing |
| title_full |
PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing |
| title_fullStr |
PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing |
| title_full_unstemmed |
PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing |
| title_sort |
PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing |
| author |
Almeida, Patricia E. |
| author_facet |
Almeida, Patricia E. Carneiro, Alan Brito Silva, Adriana R. Bozza, Patrícia T. |
| author_role |
author |
| author2 |
Carneiro, Alan Brito Silva, Adriana R. Bozza, Patrícia T. |
| author2_role |
author author author |
| dc.contributor.author.fl_str_mv |
Almeida, Patricia E. Carneiro, Alan Brito Silva, Adriana R. Bozza, Patrícia T. |
| dc.subject.other.pt_BR.fl_str_mv |
Receptores Ativados por Proliferador de Peroxissomo Infecções por Micobactéria Metabolismo dos Lipídeos Imunidade |
| topic |
Receptores Ativados por Proliferador de Peroxissomo Infecções por Micobactéria Metabolismo dos Lipídeos Imunidade PPARγ Mycobacterial Infection Lipid metabolism Immunity |
| dc.subject.en.pt_BR.fl_str_mv |
PPARγ Mycobacterial Infection Lipid metabolism Immunity |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil / Universidade Federal de Juiz de Fora. Laboratório de Biologia Celular. Juiz de Fora, MG, Brasil. |
| publishDate |
2012 |
| dc.date.issued.fl_str_mv |
2012 |
| dc.date.accessioned.fl_str_mv |
2017-11-01T10:42:53Z |
| dc.date.available.fl_str_mv |
2017-11-01T10:42:53Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
ALMEIDA, Patricia E. et al. PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing. PPAR Research, volume 2012, Article ID 383829, 7p, 2012. |
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https://www.arca.fiocruz.br/handle/icict/23013 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1687-4757 |
| dc.identifier.doi.none.fl_str_mv |
10.1155/2012/383829 |
| dc.identifier.eissn.none.fl_str_mv |
1687-4765 |
| identifier_str_mv |
ALMEIDA, Patricia E. et al. PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing. PPAR Research, volume 2012, Article ID 383829, 7p, 2012. 1687-4757 10.1155/2012/383829 1687-4765 |
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https://www.arca.fiocruz.br/handle/icict/23013 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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Hindawi Publishing Corporation |
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Hindawi Publishing Corporation |
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