Protector effect of α-thalassaemia on cholecystitis and cholecystectomy in sickle cell disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/34621 |
Resumo: | 2020-08-06 |
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Pontes, Robéria M.Costa, Elaine S.Siqueira, Patrícia F. R.Medeiros, Jussara F. F.Soares, AndréaMello, Fabiana V. deMaioli, Maria C.S. Filho, Isaac L.Alves, Liliane R.Land, Marcelo G. P.Fleury, Marcos K.2019-08-06T14:14:59Z2019-08-06T14:14:59Z2017PONTES, Robéria M. et al. Protector effect of α-thalassaemia on cholecystitis and cholecystectomy in sickle cell disease. Hematology, v. 22, n. 7, p. 444-449, 2017.1024-5332https://www.arca.fiocruz.br/handle/icict/3462110.1080/10245332.2017.12893251607-8454engTaylor & FrancisProtector effect of α-thalassaemia on cholecystitis and cholecystectomy in sickle cell diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-08-06Rio de Janeiro Federal University. Faculty of Medicine. Clinical Medicine Postgraduate Program. Rio de Janeiro, RJ, Brazil.Rio de Janeiro Federal University. Faculty of Medicine. Institute of Paediatrics and Puericulture Martagão Gesteira. Department of Pediatrics. Rio de Janeiro, RJ, Brazil / Rio de Janeiro Federal University. Faculty of Medicine. Clinical Medicine Postgraduate Program. Rio de Janeiro, RJ, Brazil.Rio de Janeiro Federal University. Faculty of Medicine. Clinical Medicine Postgraduate Program. Rio de Janeiro, RJ, Brazil / Rio de Janeiro Federal University. School of Pharmacy. Department of Clinical Analysis and Toxicology. Rio de Janeiro, RJ, Brazil.University of Rio de Janeiro. Pedro Ernesto Hospital. Internal Medicine Department. Hematology Service. Rio de Janeiro, RJ, Brazil.University of Rio de Janeiro. Pedro Ernesto Hospital. Internal Medicine Department. Hematology Service. Rio de Janeiro, RJ, Brazil.Rio de Janeiro Federal University. Faculty of Medicine. Clinical Medicine Postgraduate Program. Rio de Janeiro, RJ, Brazil.University of Rio de Janeiro. Pedro Ernesto Hospital. Internal Medicine Department. Hematology Service. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.National Institute of Cancer. Pharmacy Service. Rio de Janeiro, RJ, Brazil.Rio de Janeiro Federal University. Faculty of Medicine. Institute of Paediatrics and Puericulture Martagão Gesteira. Department of Pediatrics. Rio de Janeiro, RJ, Brazil / Rio de Janeiro Federal University. Faculty of Medicine. Clinical Medicine Postgraduate Program. Rio de Janeiro, RJ, Brazil.Rio de Janeiro Federal University. School of Pharmacy. Department of Clinical Analysis and Toxicology. Rio de Janeiro, RJ, Brazil.Objectives: Cholecystitis is one of the complications of symptomatic cholelithiasis responsible for high levels of morbidity of sickle cell disease (SCD) patients. Here, we investigated the possible protective role of single gene deletions of α-thalassaemia in the occurrence of cholelithiasis and cholecystitis in SCD patients, as well as the cholecystectomy requirements. Methods: The α-globin genotype was determined in 83 SCD patients using the multiplexpolymerase chain reaction and compared with clinical events. Results: Overall, in 23% of patients, -α3.7 deletion was found. α-Thalassaemia concomitant to SCD was an independent protective factor to cholecystitis (OR = 0.07; 95% CI: 0.01–0.66; p = 0.020) and cholecystectomy requirement (OR = 0.14; 95% CI: 0.03–0.60; p = 0.008). The risk of cholelithiasis was not affected by the α-thalassaemia concomitance. Conclusions: To the best our knowledge, our study is the first to show the protective effect of αthalassaemia on cholecystitis and cholecystectomy requirements in SCD, which may be due to an improved splenic function.α-thalassaemiaSickle cell diseaseCholelithiasisCholecystitisCholecystectomyMultiplex-PCRinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/34621/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Pontes_Robéria_eta_INI_2017.pdfve_Pontes_Robéria_eta_INI_2017.pdfapplication/pdf2020938https://www.arca.fiocruz.br/bitstream/icict/34621/2/ve_Pontes_Rob%c3%a9ria_eta_INI_2017.pdfe103f172a9473cbe39cd17edc3d6f3b6MD52TEXTve_Pontes_Robéria_eta_INI_2017.pdf.txtve_Pontes_Robéria_eta_INI_2017.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Protector effect of α-thalassaemia on cholecystitis and cholecystectomy in sickle cell disease |
| title |
Protector effect of α-thalassaemia on cholecystitis and cholecystectomy in sickle cell disease |
| spellingShingle |
Protector effect of α-thalassaemia on cholecystitis and cholecystectomy in sickle cell disease Pontes, Robéria M. α-thalassaemia Sickle cell disease Cholelithiasis Cholecystitis Cholecystectomy Multiplex-PCR |
| title_short |
Protector effect of α-thalassaemia on cholecystitis and cholecystectomy in sickle cell disease |
| title_full |
Protector effect of α-thalassaemia on cholecystitis and cholecystectomy in sickle cell disease |
| title_fullStr |
Protector effect of α-thalassaemia on cholecystitis and cholecystectomy in sickle cell disease |
| title_full_unstemmed |
Protector effect of α-thalassaemia on cholecystitis and cholecystectomy in sickle cell disease |
| title_sort |
Protector effect of α-thalassaemia on cholecystitis and cholecystectomy in sickle cell disease |
| author |
Pontes, Robéria M. |
| author_facet |
Pontes, Robéria M. Costa, Elaine S. Siqueira, Patrícia F. R. Medeiros, Jussara F. F. Soares, Andréa Mello, Fabiana V. de Maioli, Maria C. S. Filho, Isaac L. Alves, Liliane R. Land, Marcelo G. P. Fleury, Marcos K. |
| author_role |
author |
| author2 |
Costa, Elaine S. Siqueira, Patrícia F. R. Medeiros, Jussara F. F. Soares, Andréa Mello, Fabiana V. de Maioli, Maria C. S. Filho, Isaac L. Alves, Liliane R. Land, Marcelo G. P. Fleury, Marcos K. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pontes, Robéria M. Costa, Elaine S. Siqueira, Patrícia F. R. Medeiros, Jussara F. F. Soares, Andréa Mello, Fabiana V. de Maioli, Maria C. S. Filho, Isaac L. Alves, Liliane R. Land, Marcelo G. P. Fleury, Marcos K. |
| dc.subject.en.pt_BR.fl_str_mv |
α-thalassaemia Sickle cell disease Cholelithiasis Cholecystitis Cholecystectomy Multiplex-PCR |
| topic |
α-thalassaemia Sickle cell disease Cholelithiasis Cholecystitis Cholecystectomy Multiplex-PCR |
| description |
2020-08-06 |
| publishDate |
2017 |
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2017 |
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2019-08-06T14:14:59Z |
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2019-08-06T14:14:59Z |
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info:eu-repo/semantics/article |
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PONTES, Robéria M. et al. Protector effect of α-thalassaemia on cholecystitis and cholecystectomy in sickle cell disease. Hematology, v. 22, n. 7, p. 444-449, 2017. |
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https://www.arca.fiocruz.br/handle/icict/34621 |
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1024-5332 |
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10.1080/10245332.2017.1289325 |
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1607-8454 |
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PONTES, Robéria M. et al. Protector effect of α-thalassaemia on cholecystitis and cholecystectomy in sickle cell disease. Hematology, v. 22, n. 7, p. 444-449, 2017. 1024-5332 10.1080/10245332.2017.1289325 1607-8454 |
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Taylor & Francis |
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Taylor & Francis |
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