Pharmacologic prevention and treatment of delirium in intensive care patients: a systematic review

Detalhes bibliográficos
Autor(a) principal: Serafim, Rodrigo B.
Data de Publicação: 2015
Outros Autores: Bozza, Fernando A., Soares, Marcio, Brasil, Pedro Emanuel A. A. do, Tura, Bernardo R., Ely, E. Wesley, Salluh, Jorge I. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34915
Resumo: 2020-08-21
id CRUZ_be768d5da5acf3c9a611fbbbb2e7117e
oai_identifier_str oai:www.arca.fiocruz.br:icict/34915
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Serafim, Rodrigo B.Bozza, Fernando A.Soares, MarcioBrasil, Pedro Emanuel A. A. doTura, Bernardo R.Ely, E. WesleySalluh, Jorge I. F.2019-08-21T12:18:15Z2019-08-21T12:18:15Z2015SERAFIM, Rodrigo B. et al. Pharmacologic prevention and treatment of delirium in intensive care patients: a systematic review. Journal of Critical Care, v. 30, n. 4, p. 799-807, Aug. 2015.0883-9441https://www.arca.fiocruz.br/handle/icict/3491510.1016/j.jcrc.2015.04.005engElsevierPharmacologic prevention and treatment of delirium in intensive care patients: a systematic reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-08-21D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Hospital Copa D’Or. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brazil.D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Instituto Nacional de Câncer. Postgraduate Program. Rio de Janeiro, RJ, Brazil.D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.D’Or Institute for Research and Education. Rio de Janeiro, RJ, BrazilVanderbilt University School of Medicin. Nashville, TN, USA / Veteran Affairs Tennessee Valley Geriatric Research Education Clinical Center. Nashville, TN, USA.D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brazil.Purpose: The purpose of the study is to determine if pharmacologic approaches are effective in prevention and treatment of delirium in critically ill patients. Materials and methods: We performed a systematic search to identify publications (from January 1980 to September 2014) that evaluated the pharmacologic interventions to treat or prevent delirium in intensive careunit (ICU) patients. Results: From 2646 citations, 15 studies on prevention (6729 patients) and 7 studies on treatment (1784 patients) were selected and analyzed. Among studies that evaluated surgical patients, the pharmacologic interventions were associated with a reduction in delirium prevalence, ICU length of stay, and duration of mechanical ventilation, but with high heterogeneity (respectively, I2= 81%, P=.0013; I2=97%, Pb.001; and I2= 97%). Considering treatment studies, only 1 demonstrated a significant decrease in ICU length of stay using dexmedetomidine compared to haloperidol (Relative Risk, 0.62 [1.29-0.06]; I2= 97%), and only 1 found a shorter time to resolution of delirium using quetiapine (1.0 [confidence interval, 0.5-3.0] vs 4.5 [confidence interval, 2.0-7.0] days; P= .001). Conclusion: The use of antipsychotics for surgical ICU patients and dexmedetomidine for mechanically ventilated patients as a preventive strategy may reduce the prevalence of delirium in the ICU. None of the studied agents that were used for delirium treatment improved major clinical outcome, including mortality.DeliriumPreventionICUSurgicalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/34915/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Serafim_Rodrigo_etal_INI_2015.pdfve_Serafim_Rodrigo_etal_INI_2015.pdfapplication/pdf1137477https://www.arca.fiocruz.br/bitstream/icict/34915/2/ve_Serafim_Rodrigo_etal_INI_2015.pdfdcaf65d901fad1be73bf4e4b4e821d8aMD52TEXTve_Serafim_Rodrigo_etal_INI_2015.pdf.txtve_Serafim_Rodrigo_etal_INI_2015.pdf.txtExtracted texttext/plain47195https://www.arca.fiocruz.br/bitstream/icict/34915/3/ve_Serafim_Rodrigo_etal_INI_2015.pdf.txte23e9d1b164d6832d43d1ce812f484b2MD53icict/349152021-03-24 16:32:35.642oai:www.arca.fiocruz.br:icict/34915Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:35Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Pharmacologic prevention and treatment of delirium in intensive care patients: a systematic review
title Pharmacologic prevention and treatment of delirium in intensive care patients: a systematic review
spellingShingle Pharmacologic prevention and treatment of delirium in intensive care patients: a systematic review
Serafim, Rodrigo B.
Delirium
Prevention
ICU
Surgical
title_short Pharmacologic prevention and treatment of delirium in intensive care patients: a systematic review
title_full Pharmacologic prevention and treatment of delirium in intensive care patients: a systematic review
title_fullStr Pharmacologic prevention and treatment of delirium in intensive care patients: a systematic review
title_full_unstemmed Pharmacologic prevention and treatment of delirium in intensive care patients: a systematic review
title_sort Pharmacologic prevention and treatment of delirium in intensive care patients: a systematic review
author Serafim, Rodrigo B.
author_facet Serafim, Rodrigo B.
Bozza, Fernando A.
Soares, Marcio
Brasil, Pedro Emanuel A. A. do
Tura, Bernardo R.
Ely, E. Wesley
Salluh, Jorge I. F.
author_role author
author2 Bozza, Fernando A.
Soares, Marcio
Brasil, Pedro Emanuel A. A. do
Tura, Bernardo R.
Ely, E. Wesley
Salluh, Jorge I. F.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Serafim, Rodrigo B.
Bozza, Fernando A.
Soares, Marcio
Brasil, Pedro Emanuel A. A. do
Tura, Bernardo R.
Ely, E. Wesley
Salluh, Jorge I. F.
dc.subject.en.pt_BR.fl_str_mv Delirium
Prevention
ICU
Surgical
topic Delirium
Prevention
ICU
Surgical
description 2020-08-21
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-08-21T12:18:15Z
dc.date.available.fl_str_mv 2019-08-21T12:18:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SERAFIM, Rodrigo B. et al. Pharmacologic prevention and treatment of delirium in intensive care patients: a systematic review. Journal of Critical Care, v. 30, n. 4, p. 799-807, Aug. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34915
dc.identifier.issn.pt_BR.fl_str_mv 0883-9441
dc.identifier.doi.none.fl_str_mv 10.1016/j.jcrc.2015.04.005
identifier_str_mv SERAFIM, Rodrigo B. et al. Pharmacologic prevention and treatment of delirium in intensive care patients: a systematic review. Journal of Critical Care, v. 30, n. 4, p. 799-807, Aug. 2015.
0883-9441
10.1016/j.jcrc.2015.04.005
url https://www.arca.fiocruz.br/handle/icict/34915
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/34915/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/34915/2/ve_Serafim_Rodrigo_etal_INI_2015.pdf
https://www.arca.fiocruz.br/bitstream/icict/34915/3/ve_Serafim_Rodrigo_etal_INI_2015.pdf.txt
bitstream.checksum.fl_str_mv 8a4605be74aa9ea9d79846c1fba20a33
dcaf65d901fad1be73bf4e4b4e821d8a
e23e9d1b164d6832d43d1ce812f484b2
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009312984858624

Registros relacionados