Increased Pro-inflammatory Cytokines (TNF-a and IL-6) and Anti-inflammatory Compounds (sTNFRp55 and sTNFRp75) in Brazilian Patients during Exanthematic Dengue Fever
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1999 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/44021 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. |
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Pinto, Luzia M. OOliveira, Solange A.Braga, Elzinandes L. A.Nogueira, R. M. R.Kubelka, Claire F.2020-10-16T19:14:08Z2020-10-16T19:14:08Z1999PINTO, Luzia M. O. et al. Increased Pro-inflammatory Cytokines (TNF-a and IL-6) and Anti-inflammatory Compounds (sTNFRp55 and sTNFRp75) in Brazilian Patients during Exanthematic Dengue Fever. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, n. 3, p. 387-394, May/June 1999.0074-0276https://www.arca.fiocruz.br/handle/icict/4402110.1590/S0074-027619990003000191678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.DengueFator de necrose tumoral aInterleukin 6Necrose tumoral solúvelFator de receptorDengueTumor necrotis factor aInterleukin 6Soluble tumor necrosisFactor receptorIncreased Pro-inflammatory Cytokines (TNF-a and IL-6) and Anti-inflammatory Compounds (sTNFRp55 and sTNFRp75) in Brazilian Patients during Exanthematic Dengue Feverinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Disciplina de Doenças Infecto-Parasitárias. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Pro-inflammatory cytokines, tumor necrosis factor (TNF-a), interleukin-6 (IL-6) and interleukin-1b (IL-1b) as well as anti-inflammatory compounds, soluble TNF-Receptor p55 (sTNFRp55), sTNFRp75 and IL-1 receptor antagonist (sIL-1Ra), were investigated in 34 Brazilian cases of dengue fever (DF) originated from a study of exanthematic virosis. The presence of pro-inflammatory cytokines was detected in sera from these patients by ELISA. TNF-a and IL-6 levels were significantly higher than control subjects in 32% and 52% patients, respectively. To our knowledge this was the first time a receptor antagonist and soluble receptors for cytokines were detected in sera obtained during exanthematic DF without hemorrhagic manifestations. Both sTNFRp55 and sTNFRp75 were consistently elevated in 42% and 84% patients, respectively. Most patients had IL-1b levels not different from those of normal subjects, except for one case. Only 16% patients had altered levels of IL-1Ra. Previous studies in dengue hemorrhagic fever patients demonstrated production of these soluble factors; here we observed that they are found in absence of hemorrhagic manifestations. The possible role of these anti-inflammatory compounds in immune cell activation and in regulating cytokine-mediated pathogenesis during dengue infection is discussed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44021/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLuziaMOPinto_ClaireKubelka_etal_IOC_1999.pdfLuziaMOPinto_ClaireKubelka_etal_IOC_1999.pdfapplication/pdf124516https://www.arca.fiocruz.br/bitstream/icict/44021/2/LuziaMOPinto_ClaireKubelka_etal_IOC_1999.pdff306227dd631f7b93d371decc22e2e68MD52TEXTLuziaMOPinto_ClaireKubelka_etal_IOC_1999.pdf.txtLuziaMOPinto_ClaireKubelka_etal_IOC_1999.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Increased Pro-inflammatory Cytokines (TNF-a and IL-6) and Anti-inflammatory Compounds (sTNFRp55 and sTNFRp75) in Brazilian Patients during Exanthematic Dengue Fever |
| title |
Increased Pro-inflammatory Cytokines (TNF-a and IL-6) and Anti-inflammatory Compounds (sTNFRp55 and sTNFRp75) in Brazilian Patients during Exanthematic Dengue Fever |
| spellingShingle |
Increased Pro-inflammatory Cytokines (TNF-a and IL-6) and Anti-inflammatory Compounds (sTNFRp55 and sTNFRp75) in Brazilian Patients during Exanthematic Dengue Fever Pinto, Luzia M. O Dengue Fator de necrose tumoral a Interleukin 6 Necrose tumoral solúvel Fator de receptor Dengue Tumor necrotis factor a Interleukin 6 Soluble tumor necrosis Factor receptor |
| title_short |
Increased Pro-inflammatory Cytokines (TNF-a and IL-6) and Anti-inflammatory Compounds (sTNFRp55 and sTNFRp75) in Brazilian Patients during Exanthematic Dengue Fever |
| title_full |
Increased Pro-inflammatory Cytokines (TNF-a and IL-6) and Anti-inflammatory Compounds (sTNFRp55 and sTNFRp75) in Brazilian Patients during Exanthematic Dengue Fever |
| title_fullStr |
Increased Pro-inflammatory Cytokines (TNF-a and IL-6) and Anti-inflammatory Compounds (sTNFRp55 and sTNFRp75) in Brazilian Patients during Exanthematic Dengue Fever |
| title_full_unstemmed |
Increased Pro-inflammatory Cytokines (TNF-a and IL-6) and Anti-inflammatory Compounds (sTNFRp55 and sTNFRp75) in Brazilian Patients during Exanthematic Dengue Fever |
| title_sort |
Increased Pro-inflammatory Cytokines (TNF-a and IL-6) and Anti-inflammatory Compounds (sTNFRp55 and sTNFRp75) in Brazilian Patients during Exanthematic Dengue Fever |
| author |
Pinto, Luzia M. O |
| author_facet |
Pinto, Luzia M. O Oliveira, Solange A. Braga, Elzinandes L. A. Nogueira, R. M. R. Kubelka, Claire F. |
| author_role |
author |
| author2 |
Oliveira, Solange A. Braga, Elzinandes L. A. Nogueira, R. M. R. Kubelka, Claire F. |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Pinto, Luzia M. O Oliveira, Solange A. Braga, Elzinandes L. A. Nogueira, R. M. R. Kubelka, Claire F. |
| dc.subject.other.pt_BR.fl_str_mv |
Dengue Fator de necrose tumoral a Interleukin 6 Necrose tumoral solúvel Fator de receptor |
| topic |
Dengue Fator de necrose tumoral a Interleukin 6 Necrose tumoral solúvel Fator de receptor Dengue Tumor necrotis factor a Interleukin 6 Soluble tumor necrosis Factor receptor |
| dc.subject.en.pt_BR.fl_str_mv |
Dengue Tumor necrotis factor a Interleukin 6 Soluble tumor necrosis Factor receptor |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. |
| publishDate |
1999 |
| dc.date.issued.fl_str_mv |
1999 |
| dc.date.accessioned.fl_str_mv |
2020-10-16T19:14:08Z |
| dc.date.available.fl_str_mv |
2020-10-16T19:14:08Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
PINTO, Luzia M. O. et al. Increased Pro-inflammatory Cytokines (TNF-a and IL-6) and Anti-inflammatory Compounds (sTNFRp55 and sTNFRp75) in Brazilian Patients during Exanthematic Dengue Fever. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, n. 3, p. 387-394, May/June 1999. |
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https://www.arca.fiocruz.br/handle/icict/44021 |
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0074-0276 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S0074-02761999000300019 |
| dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
| identifier_str_mv |
PINTO, Luzia M. O. et al. Increased Pro-inflammatory Cytokines (TNF-a and IL-6) and Anti-inflammatory Compounds (sTNFRp55 and sTNFRp75) in Brazilian Patients during Exanthematic Dengue Fever. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, n. 3, p. 387-394, May/June 1999. 0074-0276 10.1590/S0074-02761999000300019 1678-8060 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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