Leukotriene B4 mediates neutrophil migration induced by heme
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23081 |
Resumo: | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. |
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Monteiro, Ana Paula T.Pinheiro, Carla S.Gomes, Tatiana LunaAlves, Liliane R.Monteiro, Clarissa M. MayaPorto, Barbara N.Fidalgo, Christina BarjaBenjamim, Claudia F.Peters-Golden, MarcMelo, Christianne BandeiraBozza, Marcelo T.Canetti, Claudio2017-11-09T09:53:44Z2017-11-09T09:53:44Z2011MONTEIRO, Ana Paula T. et al. Leukotriene B4 Mediates Neutrophil Migration Induced by Heme.J. Immunol., v.186, p.6562-6567, May 2011.0022-1767https://www.arca.fiocruz.br/handle/icict/2308110.4049/jimmunol.10024001550-660engAmerican Association of ImmunologistsLeucotrieno B4NeutrófilosHemeInflamaçãoLeukotriene B4NeutrophilHemeInflammationLeukotriene B4 mediates neutrophil migration induced by hemeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Departamento de Farmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, brasilUniversity of Michigan. Department of Internal Medicine, Division of Pulmonary and Critical care Medicine. Ann Arbor, MI, USA.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.High concentrations of free heme found during hemolytic events or cell damage leads to inflammation, characterized by neutrophil recruitment and production of reactive oxygen species, through mechanisms not yet elucidated. In this study, we provide evidence that heme-induced neutrophilic inflammation depends on endogenous activity of the macrophage-derived lipid mediator leukotriene B(4) (LTB(4)). In vivo, heme-induced neutrophil recruitment into the peritoneal cavity of mice was attenuated by pretreatment with 5-lipoxygenase (5-LO) inhibitors and leukotriene B(4) receptor 1 (BLT1) receptor antagonists as well as in 5-LO knockout (5-LO(-/-)) mice. Heme administration in vivo increased peritoneal levels of LTB(4) prior to and during neutrophil recruitment. Evidence that LTB(4) was synthesized by resident macrophages, but not mast cells, included the following: 1) immuno-localization of heme-induced LTB(4) was compartmentalized exclusively within lipid bodies of resident macrophages; 2) an increase in the macrophage population enhanced heme-induced neutrophil migration; 3) depletion of resident mast cells did not affect heme-induced LTB(4) production or neutrophil influx; 4) increased levels of LTB(4) were found in heme-stimulated peritoneal cavities displaying increased macrophage numbers; and 5) in vitro, heme was able to activate directly macrophages to synthesize LTB(4). Our findings uncover a crucial role of LTB(4) in neutrophil migration induced by heme and suggest that beneficial therapeutic outcomes could be achieved by targeting the 5-LO pathway in the treatment of inflammation associated with hemolytic processes.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23081/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALliliane_alves_etal_IOC_2011.pdfliliane_alves_etal_IOC_2011.pdfapplication/pdf1162327https://www.arca.fiocruz.br/bitstream/icict/23081/2/liliane_alves_etal_IOC_2011.pdf89a12a98540b379ce9ab4d420ff18be5MD52TEXTliliane_alves_etal_IOC_2011.pdf.txtliliane_alves_etal_IOC_2011.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Leukotriene B4 mediates neutrophil migration induced by heme |
| title |
Leukotriene B4 mediates neutrophil migration induced by heme |
| spellingShingle |
Leukotriene B4 mediates neutrophil migration induced by heme Monteiro, Ana Paula T. Leucotrieno B4 Neutrófilos Heme Inflamação Leukotriene B4 Neutrophil Heme Inflammation |
| title_short |
Leukotriene B4 mediates neutrophil migration induced by heme |
| title_full |
Leukotriene B4 mediates neutrophil migration induced by heme |
| title_fullStr |
Leukotriene B4 mediates neutrophil migration induced by heme |
| title_full_unstemmed |
Leukotriene B4 mediates neutrophil migration induced by heme |
| title_sort |
Leukotriene B4 mediates neutrophil migration induced by heme |
| author |
Monteiro, Ana Paula T. |
| author_facet |
Monteiro, Ana Paula T. Pinheiro, Carla S. Gomes, Tatiana Luna Alves, Liliane R. Monteiro, Clarissa M. Maya Porto, Barbara N. Fidalgo, Christina Barja Benjamim, Claudia F. Peters-Golden, Marc Melo, Christianne Bandeira Bozza, Marcelo T. Canetti, Claudio |
| author_role |
author |
| author2 |
Pinheiro, Carla S. Gomes, Tatiana Luna Alves, Liliane R. Monteiro, Clarissa M. Maya Porto, Barbara N. Fidalgo, Christina Barja Benjamim, Claudia F. Peters-Golden, Marc Melo, Christianne Bandeira Bozza, Marcelo T. Canetti, Claudio |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Monteiro, Ana Paula T. Pinheiro, Carla S. Gomes, Tatiana Luna Alves, Liliane R. Monteiro, Clarissa M. Maya Porto, Barbara N. Fidalgo, Christina Barja Benjamim, Claudia F. Peters-Golden, Marc Melo, Christianne Bandeira Bozza, Marcelo T. Canetti, Claudio |
| dc.subject.other.pt_BR.fl_str_mv |
Leucotrieno B4 Neutrófilos Heme Inflamação |
| topic |
Leucotrieno B4 Neutrófilos Heme Inflamação Leukotriene B4 Neutrophil Heme Inflammation |
| dc.subject.en.pt_BR.fl_str_mv |
Leukotriene B4 Neutrophil Heme Inflammation |
| description |
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2011 |
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2011 |
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2017-11-09T09:53:44Z |
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2017-11-09T09:53:44Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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MONTEIRO, Ana Paula T. et al. Leukotriene B4 Mediates Neutrophil Migration Induced by Heme.J. Immunol., v.186, p.6562-6567, May 2011. |
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https://www.arca.fiocruz.br/handle/icict/23081 |
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0022-1767 |
| dc.identifier.doi.none.fl_str_mv |
10.4049/jimmunol.1002400 |
| dc.identifier.eissn.none.fl_str_mv |
1550-660 |
| identifier_str_mv |
MONTEIRO, Ana Paula T. et al. Leukotriene B4 Mediates Neutrophil Migration Induced by Heme.J. Immunol., v.186, p.6562-6567, May 2011. 0022-1767 10.4049/jimmunol.1002400 1550-660 |
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American Association of Immunologists |
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American Association of Immunologists |
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