Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study

Detalhes bibliográficos
Autor(a) principal: Silva, Paula Simplício da
Data de Publicação: 2017
Outros Autores: Mediano, Mauro Felippe Felix, Silva, Gilberto Marcelo Sperandio da, Brito, Patricia Dias de, Cardoso, Claudia Santos de Aguiar, Almeida, Cristiane Fonseca de, Sangenis, Luiz Henrique Conde, Pinheiro, Roberta Olmo, Hasslocher-Moreno, Alejandro Marcel, Brasil, Pedro Emmanuel Alvarenga Americano do, Sousa, Andrea Silvestre de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/24962
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Serviço de Nutrição. Rio de Janeiro, RJ. Brasil.
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spelling Silva, Paula Simplício daMediano, Mauro Felippe FelixSilva, Gilberto Marcelo Sperandio daBrito, Patricia Dias deCardoso, Claudia Santos de AguiarAlmeida, Cristiane Fonseca deSangenis, Luiz Henrique CondePinheiro, Roberta OlmoHasslocher-Moreno, Alejandro MarcelBrasil, Pedro Emmanuel Alvarenga Americano doSousa, Andrea Silvestre de2018-02-27T13:26:53Z2018-02-27T13:26:53Z2017SILVA, Paula Simplício da et al. Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study. Nutrition Journal, v. 16, n. 36, p.1-9, 2017.1475-2891https://www.arca.fiocruz.br/handle/icict/2496210.1186/s12937-017-0259-0engBioMed CentralDoença de ChagasOmega-3Cardiomiopatia chagásicaCitocinasPerfil lipidicoChagas DiseaseChagas cardiomyopathyOmega-3CytokinesLipid profileOmega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Serviço de Nutrição. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Serviço de Nutrição. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Serviço de Nutrição. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Serviço de Nutrição. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de janeiro, RJ, Brasil.Fundação Oswaldo Cruz .Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de janeiro, RJ, Brasil.Background: Several studies have been focusing on the effect of omega-3 polyunsaturated fatty acids on modulation of inflammatory markers in several cardiopathies. Although immunoregulatory dysfunction has been associated to the chronic cardiac involvement in Chagas disease, there is no study examining the effects of omega-3 supplementation in these patients. We investigated the effects of omega-3 PUFAs on markers of inflammation and lipid profile in chronic Chagas cardiomyopathy patients. Methods: The present study was a single-center double-blind clinical trial including patients with chronic Chagas cardiomyopathy. Patients were randomly assigned to receive omega-3 PUFAs capsules (1.8g EPA and 1.2g DHA) or placebo (corn oil) during an 8-week period. Cytokines, fasting glucose, lipid, and anthropometric profiles were evaluated. Results: Forty-two patients (23 women and 19 men) were included in the study and there were only two losses to follow-up during the 8-week period. Most of sociodemographic and clinical characteristics were similar between the groups at baseline, except for the cytokines IL-1β, IL-6, IL-8, IL-10, IL-17α, and IFNγ. The omega-3 PUFAs group demonstrated greater improvements in serum triglycerides (-21.1 vs. -4.1; p = 0.05) and IL-10 levels (-10.6 vs. -35.7; p = 0.01) in comparison to controls after 8 weeks of intervention. No further differences were observed between groups. Conclusion: Omega-3 PUFAs supplementation may favorably affect lipid and inflammatory profile in chronic Chagas cardiomyopathy patients, demonstrated by a decrease in triglycerides and improvements on IL-10 concentration. Further studies examining the clinical effects of omega-3 fatty acids supplementation in chronic Chagas cardiomyopathy are necessary.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24962/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALroberta_pinheiro_etal_IOC_2017.pdfroberta_pinheiro_etal_IOC_2017.pdfapplication/pdf556661https://www.arca.fiocruz.br/bitstream/icict/24962/2/roberta_pinheiro_etal_IOC_2017.pdf8e737f2e5ba49873028ffa02a73a5770MD52TEXTroberta_pinheiro_etal_IOC_2017.pdf.txtroberta_pinheiro_etal_IOC_2017.pdf.txtExtracted texttext/plain40823https://www.arca.fiocruz.br/bitstream/icict/24962/3/roberta_pinheiro_etal_IOC_2017.pdf.txt8b578fdf22e2ba37dc944e58163c017dMD53icict/249622023-09-05 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dc.title.pt_BR.fl_str_mv Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study
title Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study
spellingShingle Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study
Silva, Paula Simplício da
Doença de Chagas
Omega-3
Cardiomiopatia chagásica
Citocinas
Perfil lipidico
Chagas Disease
Chagas cardiomyopathy
Omega-3
Cytokines
Lipid profile
title_short Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study
title_full Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study
title_fullStr Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study
title_full_unstemmed Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study
title_sort Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study
author Silva, Paula Simplício da
author_facet Silva, Paula Simplício da
Mediano, Mauro Felippe Felix
Silva, Gilberto Marcelo Sperandio da
Brito, Patricia Dias de
Cardoso, Claudia Santos de Aguiar
Almeida, Cristiane Fonseca de
Sangenis, Luiz Henrique Conde
Pinheiro, Roberta Olmo
Hasslocher-Moreno, Alejandro Marcel
Brasil, Pedro Emmanuel Alvarenga Americano do
Sousa, Andrea Silvestre de
author_role author
author2 Mediano, Mauro Felippe Felix
Silva, Gilberto Marcelo Sperandio da
Brito, Patricia Dias de
Cardoso, Claudia Santos de Aguiar
Almeida, Cristiane Fonseca de
Sangenis, Luiz Henrique Conde
Pinheiro, Roberta Olmo
Hasslocher-Moreno, Alejandro Marcel
Brasil, Pedro Emmanuel Alvarenga Americano do
Sousa, Andrea Silvestre de
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Paula Simplício da
Mediano, Mauro Felippe Felix
Silva, Gilberto Marcelo Sperandio da
Brito, Patricia Dias de
Cardoso, Claudia Santos de Aguiar
Almeida, Cristiane Fonseca de
Sangenis, Luiz Henrique Conde
Pinheiro, Roberta Olmo
Hasslocher-Moreno, Alejandro Marcel
Brasil, Pedro Emmanuel Alvarenga Americano do
Sousa, Andrea Silvestre de
dc.subject.other.pt_BR.fl_str_mv Doença de Chagas
Omega-3
Cardiomiopatia chagásica
Citocinas
Perfil lipidico
topic Doença de Chagas
Omega-3
Cardiomiopatia chagásica
Citocinas
Perfil lipidico
Chagas Disease
Chagas cardiomyopathy
Omega-3
Cytokines
Lipid profile
dc.subject.en.pt_BR.fl_str_mv Chagas Disease
Chagas cardiomyopathy
Omega-3
Cytokines
Lipid profile
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Serviço de Nutrição. Rio de Janeiro, RJ. Brasil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-02-27T13:26:53Z
dc.date.available.fl_str_mv 2018-02-27T13:26:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Paula Simplício da et al. Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study. Nutrition Journal, v. 16, n. 36, p.1-9, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/24962
dc.identifier.issn.pt_BR.fl_str_mv 1475-2891
dc.identifier.doi.none.fl_str_mv 10.1186/s12937-017-0259-0
identifier_str_mv SILVA, Paula Simplício da et al. Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study. Nutrition Journal, v. 16, n. 36, p.1-9, 2017.
1475-2891
10.1186/s12937-017-0259-0
url https://www.arca.fiocruz.br/handle/icict/24962
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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