New strategies for acute liver failure: focus on xenotransplantation therapy

Detalhes bibliográficos
Autor(a) principal: Alves, Luiz Anastácio
Data de Publicação: 2010
Outros Autores: Bonavita, André, Quaresma, Kátia, Torres, Elenilde, Pacheco, Paulo Anastácio Furtado, Cotta-de-Almeida, Vinícius, Saraiva, Roberto Magalhães
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32132
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.
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spelling Alves, Luiz AnastácioBonavita, AndréQuaresma, KátiaTorres, ElenildePacheco, Paulo Anastácio FurtadoCotta-de-Almeida, ViníciusSaraiva, Roberto Magalhães2019-03-18T13:03:06Z2019-03-18T13:03:06Z2010ALVES, Luiz Anastácio et al. New strategies for acute liver failure: focus on xenotransplantation therapy. Cell Medicine, v. 1, p. 47-54, 2010.2155-1790https://www.arca.fiocruz.br/handle/icict/3213210.3727/215517910X5166462155-1790engCognizant Communication CorporationNew strategies for acute liver failure: focus on xenotransplantation therapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Rio de Janeiro, RJ, Brasil.Acute liver failure (ALF) has a poor prognosis and, despite intensive care support, reported average survival is only 10-40%. The most common causes responsible for ALF are viral hepatitis (mainly hepatitis A and B) and acetaminophen poisoning. Hepatic transplantation is the only appropriate treatment for patients with unlikely survival with supportive care alone. Survival rates after transplantation can be as high as 80-90% at the end of the first year. However, there is a shortage of donors and is not uncommon that no appropriate donor matches with the patient in time to avoid death. Therefore, new technologies are in constant development, including blood purification therapies as plasmapheresis, hemodiafiltration, and bioartificial liver support. However, they are still of limited efficacy or at an experimental level, and new strategies are welcome. Accordingly, cell transplantation has been developed to serve as a possible bridge to spontaneous recovery or liver transplantation. Xenotransplant of adult hepatocytes offers an interesting alternative. Moreover, the development of transgenic pigs with less immunogenic cells associated with new immunosuppressor strategies has allowed the development of this area. This article reviews some of the newly developed techniques, with focus on xenotransplant of adult hepatocytes, which might have clinical benefits as future treatment for ALF.XenotransplantationAcute liver failureCell therapySurvivalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/32132/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Alves_Luiz_etal_INI_2010.pdfve_Alves_Luiz_etal_INI_2010.pdfapplication/pdf6199860https://www.arca.fiocruz.br/bitstream/icict/32132/2/ve_Alves_Luiz_etal_INI_2010.pdf4d883283eb60e10f14086d3f8957930fMD52TEXTve_Alves_Luiz_etal_INI_2010.pdf.txtve_Alves_Luiz_etal_INI_2010.pdf.txtExtracted texttext/plain38842https://www.arca.fiocruz.br/bitstream/icict/32132/3/ve_Alves_Luiz_etal_INI_2010.pdf.txtaedf2cf08484d8ae13c7304525f2d1b7MD53icict/321322019-04-04 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dc.title.pt_BR.fl_str_mv New strategies for acute liver failure: focus on xenotransplantation therapy
title New strategies for acute liver failure: focus on xenotransplantation therapy
spellingShingle New strategies for acute liver failure: focus on xenotransplantation therapy
Alves, Luiz Anastácio
Xenotransplantation
Acute liver failure
Cell therapy
Survival
title_short New strategies for acute liver failure: focus on xenotransplantation therapy
title_full New strategies for acute liver failure: focus on xenotransplantation therapy
title_fullStr New strategies for acute liver failure: focus on xenotransplantation therapy
title_full_unstemmed New strategies for acute liver failure: focus on xenotransplantation therapy
title_sort New strategies for acute liver failure: focus on xenotransplantation therapy
author Alves, Luiz Anastácio
author_facet Alves, Luiz Anastácio
Bonavita, André
Quaresma, Kátia
Torres, Elenilde
Pacheco, Paulo Anastácio Furtado
Cotta-de-Almeida, Vinícius
Saraiva, Roberto Magalhães
author_role author
author2 Bonavita, André
Quaresma, Kátia
Torres, Elenilde
Pacheco, Paulo Anastácio Furtado
Cotta-de-Almeida, Vinícius
Saraiva, Roberto Magalhães
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Alves, Luiz Anastácio
Bonavita, André
Quaresma, Kátia
Torres, Elenilde
Pacheco, Paulo Anastácio Furtado
Cotta-de-Almeida, Vinícius
Saraiva, Roberto Magalhães
dc.subject.en.pt_BR.fl_str_mv Xenotransplantation
Acute liver failure
Cell therapy
Survival
topic Xenotransplantation
Acute liver failure
Cell therapy
Survival
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2019-03-18T13:03:06Z
dc.date.available.fl_str_mv 2019-03-18T13:03:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALVES, Luiz Anastácio et al. New strategies for acute liver failure: focus on xenotransplantation therapy. Cell Medicine, v. 1, p. 47-54, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32132
dc.identifier.issn.pt_BR.fl_str_mv 2155-1790
dc.identifier.doi.none.fl_str_mv 10.3727/215517910X516646
dc.identifier.eissn.none.fl_str_mv 2155-1790
identifier_str_mv ALVES, Luiz Anastácio et al. New strategies for acute liver failure: focus on xenotransplantation therapy. Cell Medicine, v. 1, p. 47-54, 2010.
2155-1790
10.3727/215517910X516646
url https://www.arca.fiocruz.br/handle/icict/32132
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cognizant Communication Corporation
publisher.none.fl_str_mv Cognizant Communication Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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