In the presence of Trypanosoma cruzi antigens, activated peripheral T lymphocytes retained in the liver induce a proinflammatory phenotypic and functional shift in intrahepatic T lymphocyte

Detalhes bibliográficos
Autor(a) principal: Meuser-Batista, Marcelo
Data de Publicação: 2020
Outros Autores: Vacani-Martins, Natalia, Cascabulho, Cynthia Machado, Beghini, Daniela Gois, Henriques-Pons, Andrea
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42834
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil. / Fundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Departamento de Anatomia Patológica e Citopatologia. Rio de Janeiro, RJ. Brasil.
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spelling Meuser-Batista, MarceloVacani-Martins, NataliaCascabulho, Cynthia MachadoBeghini, Daniela GoisHenriques-Pons, Andrea2020-08-18T20:25:15Z2020-08-18T20:25:15Z2020Meuser‐Batista, M, Vacani‐Martins, N, Cascabulho, CM, Beghini, DG, Henriques‐Pons, A. In the presence of Trypanosoma cruzi antigens, activated peripheral T lymphocytes retained in the liver induce a proinflammatory phenotypic and functional shift in intrahepatic T lymphocyte . J Leukoc Biol. 2020; 107: 695– 706. https://doi.org/10.1002/JLB.3A0220-399RR0741-5400https://www.arca.fiocruz.br/handle/icict/4283410.1002/JLB.3A0220-399RRengSociety for Leukocyte Biology [Society Publisher], Wiley [Commercial Publisher]In the presence of Trypanosoma cruzi antigens, activated peripheral T lymphocytes retained in the liver induce a proinflammatory phenotypic and functional shift in intrahepatic T lymphocyteinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil. / Fundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Departamento de Anatomia Patológica e Citopatologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil.In secondary lymphoid organs, pathogen-derived and endogenous danger molecules are recognized by pattern recognition receptors, leading to adaptive proinflammatory immune responses. This conceptual rule does not apply directly to the liver, as hepatic immune cells tolerate gut-derived bacterial molecules from the flora. Therefore, the recognition of danger and proinflammatory stimuli differs between the periphery and the liver. However, the tolerant nature of the liver must be overcome in the case of infections or cancer, for example. The central paradigm is the basis for danger recognition and the balance between inflammation and tolerance in the liver. Here, we observed functional integration, with activated peripheral T lymphocytes playing a role in the induction of a proinflammatory environment in the liver in the presence of Trypanosoma cruzi antigens. When only parasite extract was orally administered, it led to the up-regulation of hepatic tolerance markers, but oral treatment plus adoptively transferred activated splenic T lymphocytes led to a proinflammatory response. Moreover, treated/recipient mice showed increased levels of TNF, IFN-γ, IL-6, and CCL2 in the liver and increased numbers of effector and/or effector memory T lymphocytes and F4/80+ cells. There was a reduction in FoxP3+ Treg cells, NKT cells, and γδ T lymphocytes with increased liver damage in the presence of activated peripheral T cells. Our results show that the induction of a proinflammatory liver response against T. cruzi danger molecules is at least partially dependent on cooperation with activated peripheral T cells.Trypanosoma. cruzihepatic T lymphocytesliver immune responseperipheral T cellspathogen‐associated molecular pattern (PAMP)hepatic immunoregulationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42834/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJLB-107-695.pdfJLB-107-695.pdfapplication/pdf3922026https://www.arca.fiocruz.br/bitstream/icict/42834/2/JLB-107-695.pdf6e72bf780794d2078850565e751765d2MD52TEXTJLB-107-695.pdf.txtJLB-107-695.pdf.txtExtracted texttext/plain54427https://www.arca.fiocruz.br/bitstream/icict/42834/3/JLB-107-695.pdf.txt8ccdbab2363fe73945d92f403700b5e3MD53icict/428342020-08-19 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dc.title.pt_BR.fl_str_mv In the presence of Trypanosoma cruzi antigens, activated peripheral T lymphocytes retained in the liver induce a proinflammatory phenotypic and functional shift in intrahepatic T lymphocyte
title In the presence of Trypanosoma cruzi antigens, activated peripheral T lymphocytes retained in the liver induce a proinflammatory phenotypic and functional shift in intrahepatic T lymphocyte
spellingShingle In the presence of Trypanosoma cruzi antigens, activated peripheral T lymphocytes retained in the liver induce a proinflammatory phenotypic and functional shift in intrahepatic T lymphocyte
Meuser-Batista, Marcelo
Trypanosoma. cruzi
hepatic T lymphocytes
liver immune response
peripheral T cells
pathogen‐associated molecular pattern (PAMP)
hepatic immunoregulation
title_short In the presence of Trypanosoma cruzi antigens, activated peripheral T lymphocytes retained in the liver induce a proinflammatory phenotypic and functional shift in intrahepatic T lymphocyte
title_full In the presence of Trypanosoma cruzi antigens, activated peripheral T lymphocytes retained in the liver induce a proinflammatory phenotypic and functional shift in intrahepatic T lymphocyte
title_fullStr In the presence of Trypanosoma cruzi antigens, activated peripheral T lymphocytes retained in the liver induce a proinflammatory phenotypic and functional shift in intrahepatic T lymphocyte
title_full_unstemmed In the presence of Trypanosoma cruzi antigens, activated peripheral T lymphocytes retained in the liver induce a proinflammatory phenotypic and functional shift in intrahepatic T lymphocyte
title_sort In the presence of Trypanosoma cruzi antigens, activated peripheral T lymphocytes retained in the liver induce a proinflammatory phenotypic and functional shift in intrahepatic T lymphocyte
author Meuser-Batista, Marcelo
author_facet Meuser-Batista, Marcelo
Vacani-Martins, Natalia
Cascabulho, Cynthia Machado
Beghini, Daniela Gois
Henriques-Pons, Andrea
author_role author
author2 Vacani-Martins, Natalia
Cascabulho, Cynthia Machado
Beghini, Daniela Gois
Henriques-Pons, Andrea
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Meuser-Batista, Marcelo
Vacani-Martins, Natalia
Cascabulho, Cynthia Machado
Beghini, Daniela Gois
Henriques-Pons, Andrea
dc.subject.en.pt_BR.fl_str_mv Trypanosoma. cruzi
hepatic T lymphocytes
liver immune response
peripheral T cells
pathogen‐associated molecular pattern (PAMP)
hepatic immunoregulation
topic Trypanosoma. cruzi
hepatic T lymphocytes
liver immune response
peripheral T cells
pathogen‐associated molecular pattern (PAMP)
hepatic immunoregulation
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil. / Fundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Departamento de Anatomia Patológica e Citopatologia. Rio de Janeiro, RJ. Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-08-18T20:25:15Z
dc.date.available.fl_str_mv 2020-08-18T20:25:15Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Meuser‐Batista, M, Vacani‐Martins, N, Cascabulho, CM, Beghini, DG, Henriques‐Pons, A. In the presence of Trypanosoma cruzi antigens, activated peripheral T lymphocytes retained in the liver induce a proinflammatory phenotypic and functional shift in intrahepatic T lymphocyte . J Leukoc Biol. 2020; 107: 695– 706. https://doi.org/10.1002/JLB.3A0220-399RR
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42834
dc.identifier.issn.pt_BR.fl_str_mv 0741-5400
dc.identifier.doi.none.fl_str_mv 10.1002/JLB.3A0220-399RR
identifier_str_mv Meuser‐Batista, M, Vacani‐Martins, N, Cascabulho, CM, Beghini, DG, Henriques‐Pons, A. In the presence of Trypanosoma cruzi antigens, activated peripheral T lymphocytes retained in the liver induce a proinflammatory phenotypic and functional shift in intrahepatic T lymphocyte . J Leukoc Biol. 2020; 107: 695– 706. https://doi.org/10.1002/JLB.3A0220-399RR
0741-5400
10.1002/JLB.3A0220-399RR
url https://www.arca.fiocruz.br/handle/icict/42834
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Society for Leukocyte Biology [Society Publisher], Wiley [Commercial Publisher]
publisher.none.fl_str_mv Society for Leukocyte Biology [Society Publisher], Wiley [Commercial Publisher]
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/42834/1/license.txt
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https://www.arca.fiocruz.br/bitstream/icict/42834/3/JLB-107-695.pdf.txt
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