Thiosemicarbazones as Aedes aegypti larvicidal
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20539 |
Resumo: | Moreira, Diogo Rodrigo de Magalhães “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. a Departamento de Química Fundamental, Centro de Ciências Exatas e da Natureza, Universidade Federal de Pernambuco, 50670-901, Recife, PE, Brazil b Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, 50740-521, Recife, PE, Brazil c Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, 50670-420, Recife, PE, Brazil d Department of Entomology, University of WisconsineMadison, 1630 Linden Drive, Madison, WI 53706, USA e Quantum Theory Project, University of Florida, 2234 New Physics Building, Gainesville, PO Box 118435, Florida, USA |
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Silva, João Bosco Paraiso daNavarro, Daniela Maria do Amaral FerrazSilva, Aluizio Galdaino daSantos, Geanne Karla NovisDutra, Kamilla de AndradeMoreira, Diogo Rodrigo de MagalhãesRamos, Mozart NevesEspíndola, José Wanderlan PontesOliveira, Ana Daura Travassos deBrondani, Dalci JoséLeite, Ana Cristina LimaHernandes, Marcelo ZaldiniPereira, Valéria R. ARocha, Lucas F. daCastro, Maria Carolina Accioly Brelaz deOliveira, Beatriz Coutinho deLan, QueMerz, Kenneth M2017-08-08T16:48:00Z2017-08-08T16:48:00Z2015SILVA, J. B. P. et al. Thiosemicarbazones as Aedes aegypti larvicidal. European Journal of Medicinal Chemistry, v. 100, p. 162e175, 2015.0223-5234https://www.arca.fiocruz.br/handle/icict/2053910.1016/j.ejmech.2015.04.061Moreira, Diogo Rodrigo de Magalhães “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. a Departamento de Química Fundamental, Centro de Ciências Exatas e da Natureza, Universidade Federal de Pernambuco, 50670-901, Recife, PE, Brazil b Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, 50740-521, Recife, PE, Brazil c Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, 50670-420, Recife, PE, Brazil d Department of Entomology, University of WisconsineMadison, 1630 Linden Drive, Madison, WI 53706, USA e Quantum Theory Project, University of Florida, 2234 New Physics Building, Gainesville, PO Box 118435, Florida, USAFACEPE/CNPq/PRONEX, FACEPE/PPSUS-2008 and Dengue Institute/CNPqMúltipla - ver em NotasA set of aryl- and phenoxymethyl-(thio)semicarbazones were synthetized, characterized and biologically evaluated against the larvae of Aedes aegypti (A. aegypti), the vector responsible for diseases like Dengue and Yellow Fever. (Q)SAR studies were useful for predicting the activities of the compounds not included to create the QSAR model as well as to predict the features of a new compound with improved activity. Docking studies corroborated experimental evidence of AeSCP-2 as a potential target able to explain the larvicidal properties of its compounds. The trend observed between the in silico Docking scores and the in vitro pLC50 (equals -log LC50, at molar concentration) data indicated that the highest larvicidal compounds, or the compounds with the highest values for pLC50, are usually those with the higher docking scores (i.e., greater in silico affinity for the AeSCP-2 target). Determination of cytotoxicity for these compounds in mammal cells demonstrated that the top larvicide compounds are non-toxic.engElsevierAedes aegyptiLarvicidasSemicarbazonasProteína esterolina-2Aedes aegyptiLarvicideThiosemicarbazonesSterol carrier protein-2QSARDockingThiosemicarbazones as Aedes aegypti larvicidalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20539/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSilva JBP Thiosemicarbazones as aedes....pdfSilva JBP Thiosemicarbazones as aedes....pdfapplication/pdf1457719https://www.arca.fiocruz.br/bitstream/icict/20539/2/Silva%20JBP%20Thiosemicarbazones%20as%20aedes....pdfdf436b14d46c93f79a0209c9ba554a60MD52TEXTSilva JBP Thiosemicarbazones as aedes....pdf.txtSilva 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| dc.title.pt_BR.fl_str_mv |
Thiosemicarbazones as Aedes aegypti larvicidal |
| title |
Thiosemicarbazones as Aedes aegypti larvicidal |
| spellingShingle |
Thiosemicarbazones as Aedes aegypti larvicidal Silva, João Bosco Paraiso da Aedes aegypti Larvicidas Semicarbazonas Proteína esterolina-2 Aedes aegypti Larvicide Thiosemicarbazones Sterol carrier protein-2 QSAR Docking |
| title_short |
Thiosemicarbazones as Aedes aegypti larvicidal |
| title_full |
Thiosemicarbazones as Aedes aegypti larvicidal |
| title_fullStr |
Thiosemicarbazones as Aedes aegypti larvicidal |
| title_full_unstemmed |
Thiosemicarbazones as Aedes aegypti larvicidal |
| title_sort |
Thiosemicarbazones as Aedes aegypti larvicidal |
| author |
Silva, João Bosco Paraiso da |
| author_facet |
Silva, João Bosco Paraiso da Navarro, Daniela Maria do Amaral Ferraz Silva, Aluizio Galdaino da Santos, Geanne Karla Novis Dutra, Kamilla de Andrade Moreira, Diogo Rodrigo de Magalhães Ramos, Mozart Neves Espíndola, José Wanderlan Pontes Oliveira, Ana Daura Travassos de Brondani, Dalci José Leite, Ana Cristina Lima Hernandes, Marcelo Zaldini Pereira, Valéria R. A Rocha, Lucas F. da Castro, Maria Carolina Accioly Brelaz de Oliveira, Beatriz Coutinho de Lan, Que Merz, Kenneth M |
| author_role |
author |
| author2 |
Navarro, Daniela Maria do Amaral Ferraz Silva, Aluizio Galdaino da Santos, Geanne Karla Novis Dutra, Kamilla de Andrade Moreira, Diogo Rodrigo de Magalhães Ramos, Mozart Neves Espíndola, José Wanderlan Pontes Oliveira, Ana Daura Travassos de Brondani, Dalci José Leite, Ana Cristina Lima Hernandes, Marcelo Zaldini Pereira, Valéria R. A Rocha, Lucas F. da Castro, Maria Carolina Accioly Brelaz de Oliveira, Beatriz Coutinho de Lan, Que Merz, Kenneth M |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, João Bosco Paraiso da Navarro, Daniela Maria do Amaral Ferraz Silva, Aluizio Galdaino da Santos, Geanne Karla Novis Dutra, Kamilla de Andrade Moreira, Diogo Rodrigo de Magalhães Ramos, Mozart Neves Espíndola, José Wanderlan Pontes Oliveira, Ana Daura Travassos de Brondani, Dalci José Leite, Ana Cristina Lima Hernandes, Marcelo Zaldini Pereira, Valéria R. A Rocha, Lucas F. da Castro, Maria Carolina Accioly Brelaz de Oliveira, Beatriz Coutinho de Lan, Que Merz, Kenneth M |
| dc.subject.other.pt_BR.fl_str_mv |
Aedes aegypti Larvicidas Semicarbazonas Proteína esterolina-2 |
| topic |
Aedes aegypti Larvicidas Semicarbazonas Proteína esterolina-2 Aedes aegypti Larvicide Thiosemicarbazones Sterol carrier protein-2 QSAR Docking |
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Aedes aegypti Larvicide Thiosemicarbazones Sterol carrier protein-2 QSAR Docking |
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Moreira, Diogo Rodrigo de Magalhães “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. a Departamento de Química Fundamental, Centro de Ciências Exatas e da Natureza, Universidade Federal de Pernambuco, 50670-901, Recife, PE, Brazil b Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, 50740-521, Recife, PE, Brazil c Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, 50670-420, Recife, PE, Brazil d Department of Entomology, University of WisconsineMadison, 1630 Linden Drive, Madison, WI 53706, USA e Quantum Theory Project, University of Florida, 2234 New Physics Building, Gainesville, PO Box 118435, Florida, USA |
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2015 |
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2015 |
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2017-08-08T16:48:00Z |
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2017-08-08T16:48:00Z |
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SILVA, J. B. P. et al. Thiosemicarbazones as Aedes aegypti larvicidal. European Journal of Medicinal Chemistry, v. 100, p. 162e175, 2015. |
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https://www.arca.fiocruz.br/handle/icict/20539 |
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0223-5234 |
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10.1016/j.ejmech.2015.04.061 |
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SILVA, J. B. P. et al. Thiosemicarbazones as Aedes aegypti larvicidal. European Journal of Medicinal Chemistry, v. 100, p. 162e175, 2015. 0223-5234 10.1016/j.ejmech.2015.04.061 |
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