Thiosemicarbazones as Aedes aegypti larvicidal

Detalhes bibliográficos
Autor(a) principal: Silva, João Bosco Paraiso da
Data de Publicação: 2015
Outros Autores: Navarro, Daniela Maria do Amaral Ferraz, Silva, Aluizio Galdaino da, Santos, Geanne Karla Novis, Dutra, Kamilla de Andrade, Moreira, Diogo Rodrigo de Magalhães, Ramos, Mozart Neves, Espíndola, José Wanderlan Pontes, Oliveira, Ana Daura Travassos de, Brondani, Dalci José, Leite, Ana Cristina Lima, Hernandes, Marcelo Zaldini, Pereira, Valéria R. A, Rocha, Lucas F. da, Castro, Maria Carolina Accioly Brelaz de, Oliveira, Beatriz Coutinho de, Lan, Que, Merz, Kenneth M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20539
Resumo: Moreira, Diogo Rodrigo de Magalhães “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. a Departamento de Química Fundamental, Centro de Ciências Exatas e da Natureza, Universidade Federal de Pernambuco, 50670-901, Recife, PE, Brazil b Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, 50740-521, Recife, PE, Brazil c Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, 50670-420, Recife, PE, Brazil d Department of Entomology, University of WisconsineMadison, 1630 Linden Drive, Madison, WI 53706, USA e Quantum Theory Project, University of Florida, 2234 New Physics Building, Gainesville, PO Box 118435, Florida, USA
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spelling Silva, João Bosco Paraiso daNavarro, Daniela Maria do Amaral FerrazSilva, Aluizio Galdaino daSantos, Geanne Karla NovisDutra, Kamilla de AndradeMoreira, Diogo Rodrigo de MagalhãesRamos, Mozart NevesEspíndola, José Wanderlan PontesOliveira, Ana Daura Travassos deBrondani, Dalci JoséLeite, Ana Cristina LimaHernandes, Marcelo ZaldiniPereira, Valéria R. ARocha, Lucas F. daCastro, Maria Carolina Accioly Brelaz deOliveira, Beatriz Coutinho deLan, QueMerz, Kenneth M2017-08-08T16:48:00Z2017-08-08T16:48:00Z2015SILVA, J. B. P. et al. Thiosemicarbazones as Aedes aegypti larvicidal. European Journal of Medicinal Chemistry, v. 100, p. 162e175, 2015.0223-5234https://www.arca.fiocruz.br/handle/icict/2053910.1016/j.ejmech.2015.04.061Moreira, Diogo Rodrigo de Magalhães “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. a Departamento de Química Fundamental, Centro de Ciências Exatas e da Natureza, Universidade Federal de Pernambuco, 50670-901, Recife, PE, Brazil b Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, 50740-521, Recife, PE, Brazil c Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, 50670-420, Recife, PE, Brazil d Department of Entomology, University of WisconsineMadison, 1630 Linden Drive, Madison, WI 53706, USA e Quantum Theory Project, University of Florida, 2234 New Physics Building, Gainesville, PO Box 118435, Florida, USAFACEPE/CNPq/PRONEX, FACEPE/PPSUS-2008 and Dengue Institute/CNPqMúltipla - ver em NotasA set of aryl- and phenoxymethyl-(thio)semicarbazones were synthetized, characterized and biologically evaluated against the larvae of Aedes aegypti (A. aegypti), the vector responsible for diseases like Dengue and Yellow Fever. (Q)SAR studies were useful for predicting the activities of the compounds not included to create the QSAR model as well as to predict the features of a new compound with improved activity. Docking studies corroborated experimental evidence of AeSCP-2 as a potential target able to explain the larvicidal properties of its compounds. The trend observed between the in silico Docking scores and the in vitro pLC50 (equals -log LC50, at molar concentration) data indicated that the highest larvicidal compounds, or the compounds with the highest values for pLC50, are usually those with the higher docking scores (i.e., greater in silico affinity for the AeSCP-2 target). Determination of cytotoxicity for these compounds in mammal cells demonstrated that the top larvicide compounds are non-toxic.engElsevierAedes aegyptiLarvicidasSemicarbazonasProteína esterolina-2Aedes aegyptiLarvicideThiosemicarbazonesSterol carrier protein-2QSARDockingThiosemicarbazones as Aedes aegypti larvicidalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20539/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSilva JBP Thiosemicarbazones as aedes....pdfSilva JBP Thiosemicarbazones as aedes....pdfapplication/pdf1457719https://www.arca.fiocruz.br/bitstream/icict/20539/2/Silva%20JBP%20Thiosemicarbazones%20as%20aedes....pdfdf436b14d46c93f79a0209c9ba554a60MD52TEXTSilva JBP Thiosemicarbazones as aedes....pdf.txtSilva 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dc.title.pt_BR.fl_str_mv Thiosemicarbazones as Aedes aegypti larvicidal
title Thiosemicarbazones as Aedes aegypti larvicidal
spellingShingle Thiosemicarbazones as Aedes aegypti larvicidal
Silva, João Bosco Paraiso da
Aedes aegypti
Larvicidas
Semicarbazonas
Proteína esterolina-2
Aedes aegypti
Larvicide
Thiosemicarbazones
Sterol carrier protein-2
QSAR
Docking
title_short Thiosemicarbazones as Aedes aegypti larvicidal
title_full Thiosemicarbazones as Aedes aegypti larvicidal
title_fullStr Thiosemicarbazones as Aedes aegypti larvicidal
title_full_unstemmed Thiosemicarbazones as Aedes aegypti larvicidal
title_sort Thiosemicarbazones as Aedes aegypti larvicidal
author Silva, João Bosco Paraiso da
author_facet Silva, João Bosco Paraiso da
Navarro, Daniela Maria do Amaral Ferraz
Silva, Aluizio Galdaino da
Santos, Geanne Karla Novis
Dutra, Kamilla de Andrade
Moreira, Diogo Rodrigo de Magalhães
Ramos, Mozart Neves
Espíndola, José Wanderlan Pontes
Oliveira, Ana Daura Travassos de
Brondani, Dalci José
Leite, Ana Cristina Lima
Hernandes, Marcelo Zaldini
Pereira, Valéria R. A
Rocha, Lucas F. da
Castro, Maria Carolina Accioly Brelaz de
Oliveira, Beatriz Coutinho de
Lan, Que
Merz, Kenneth M
author_role author
author2 Navarro, Daniela Maria do Amaral Ferraz
Silva, Aluizio Galdaino da
Santos, Geanne Karla Novis
Dutra, Kamilla de Andrade
Moreira, Diogo Rodrigo de Magalhães
Ramos, Mozart Neves
Espíndola, José Wanderlan Pontes
Oliveira, Ana Daura Travassos de
Brondani, Dalci José
Leite, Ana Cristina Lima
Hernandes, Marcelo Zaldini
Pereira, Valéria R. A
Rocha, Lucas F. da
Castro, Maria Carolina Accioly Brelaz de
Oliveira, Beatriz Coutinho de
Lan, Que
Merz, Kenneth M
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, João Bosco Paraiso da
Navarro, Daniela Maria do Amaral Ferraz
Silva, Aluizio Galdaino da
Santos, Geanne Karla Novis
Dutra, Kamilla de Andrade
Moreira, Diogo Rodrigo de Magalhães
Ramos, Mozart Neves
Espíndola, José Wanderlan Pontes
Oliveira, Ana Daura Travassos de
Brondani, Dalci José
Leite, Ana Cristina Lima
Hernandes, Marcelo Zaldini
Pereira, Valéria R. A
Rocha, Lucas F. da
Castro, Maria Carolina Accioly Brelaz de
Oliveira, Beatriz Coutinho de
Lan, Que
Merz, Kenneth M
dc.subject.other.pt_BR.fl_str_mv Aedes aegypti
Larvicidas
Semicarbazonas
Proteína esterolina-2
topic Aedes aegypti
Larvicidas
Semicarbazonas
Proteína esterolina-2
Aedes aegypti
Larvicide
Thiosemicarbazones
Sterol carrier protein-2
QSAR
Docking
dc.subject.en.pt_BR.fl_str_mv Aedes aegypti
Larvicide
Thiosemicarbazones
Sterol carrier protein-2
QSAR
Docking
description Moreira, Diogo Rodrigo de Magalhães “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. a Departamento de Química Fundamental, Centro de Ciências Exatas e da Natureza, Universidade Federal de Pernambuco, 50670-901, Recife, PE, Brazil b Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, 50740-521, Recife, PE, Brazil c Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, 50670-420, Recife, PE, Brazil d Department of Entomology, University of WisconsineMadison, 1630 Linden Drive, Madison, WI 53706, USA e Quantum Theory Project, University of Florida, 2234 New Physics Building, Gainesville, PO Box 118435, Florida, USA
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2017-08-08T16:48:00Z
dc.date.available.fl_str_mv 2017-08-08T16:48:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, J. B. P. et al. Thiosemicarbazones as Aedes aegypti larvicidal. European Journal of Medicinal Chemistry, v. 100, p. 162e175, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20539
dc.identifier.issn.pt_BR.fl_str_mv 0223-5234
dc.identifier.doi.none.fl_str_mv 10.1016/j.ejmech.2015.04.061
identifier_str_mv SILVA, J. B. P. et al. Thiosemicarbazones as Aedes aegypti larvicidal. European Journal of Medicinal Chemistry, v. 100, p. 162e175, 2015.
0223-5234
10.1016/j.ejmech.2015.04.061
url https://www.arca.fiocruz.br/handle/icict/20539
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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