Differences in immune responses against Leishmania induced by infection and by immunization with killed parasite antigen: implications for vaccine discovery

Detalhes bibliográficos
Autor(a) principal: Mendonça, Sergio C. F.
Data de Publicação: 2016
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16490
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil.
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spelling Mendonça, Sergio C. F.2016-12-08T16:06:59Z2016-12-08T16:06:59Z2016MENDONÇA, Sergio C. F. Differences in immune responses against Leishmania induced by infection and by immunization with killed parasite antigen: implications for vaccine discovery. Parasites & Vectors, v.9, n.492, 9p, 2016.1756-3305https://www.arca.fiocruz.br/handle/icict/1649010.1186/s13071-016-1777-xengBioMed CentralVacinasInfecçãoImunizaçãoAntígenosImunidadeLeishmanioseImmunityLeishmaniasisAntigensInfectionImmunizationVaccinesDifferences in immune responses against Leishmania induced by infection and by immunization with killed parasite antigen: implications for vaccine discoveryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil.The leishmaniases are a group of diseases caused by different species of the protozoan genus Leishmania and transmitted by sand fly vectors. They are a major public health problem in almost all continents. There is no effective control of leishmaniasis and its geographical distribution is expanding in many countries. Great effort has been made by many scientists to develop a vaccine against leishmaniasis, but, so far, there is still no effective vaccine against the disease. The only way to generate protective immunity against leishmaniasis in humans is leishmanization, consisting of the inoculation of live virulent Leishmania as a means to acquire long-lasting immunity against subsequent infections. At present, all that we know about human immune responses to Leishmania induced by immunization with killed parasite antigens came from studies with first generation candidate vaccines (killed promastigote extracts). In the few occasions that the T cell-mediated immune responses to Leishmania induced by infection and immunization with killed parasite antigens were compared, important differences were found both in humans and in animals. This review discusses these differences and their relevance to the development of a vaccine against leishmaniasis, the major problems involved in this task, the recent prospects for the selection of candidate antigens and the use of attenuated Leishmania as live vaccines.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16490/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALsergio_mendonça_etal_IOC_2016.pdfsergio_mendonça_etal_IOC_2016.pdfapplication/pdf444773https://www.arca.fiocruz.br/bitstream/icict/16490/2/sergio_mendon%c3%a7a_etal_IOC_2016.pdf8de95ad4ccbde58fdf404826282eb60aMD52TEXTsergio_mendonça_etal_IOC_2016.pdf.txtsergio_mendonça_etal_IOC_2016.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Differences in immune responses against Leishmania induced by infection and by immunization with killed parasite antigen: implications for vaccine discovery
title Differences in immune responses against Leishmania induced by infection and by immunization with killed parasite antigen: implications for vaccine discovery
spellingShingle Differences in immune responses against Leishmania induced by infection and by immunization with killed parasite antigen: implications for vaccine discovery
Mendonça, Sergio C. F.
Vacinas
Infecção
Imunização
Antígenos
Imunidade
Leishmaniose
Immunity
Leishmaniasis
Antigens
Infection
Immunization
Vaccines
title_short Differences in immune responses against Leishmania induced by infection and by immunization with killed parasite antigen: implications for vaccine discovery
title_full Differences in immune responses against Leishmania induced by infection and by immunization with killed parasite antigen: implications for vaccine discovery
title_fullStr Differences in immune responses against Leishmania induced by infection and by immunization with killed parasite antigen: implications for vaccine discovery
title_full_unstemmed Differences in immune responses against Leishmania induced by infection and by immunization with killed parasite antigen: implications for vaccine discovery
title_sort Differences in immune responses against Leishmania induced by infection and by immunization with killed parasite antigen: implications for vaccine discovery
author Mendonça, Sergio C. F.
author_facet Mendonça, Sergio C. F.
author_role author
dc.contributor.author.fl_str_mv Mendonça, Sergio C. F.
dc.subject.other.pt_BR.fl_str_mv Vacinas
Infecção
Imunização
Antígenos
Imunidade
Leishmaniose
topic Vacinas
Infecção
Imunização
Antígenos
Imunidade
Leishmaniose
Immunity
Leishmaniasis
Antigens
Infection
Immunization
Vaccines
dc.subject.en.pt_BR.fl_str_mv Immunity
Leishmaniasis
Antigens
Infection
Immunization
Vaccines
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil.
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-12-08T16:06:59Z
dc.date.available.fl_str_mv 2016-12-08T16:06:59Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MENDONÇA, Sergio C. F. Differences in immune responses against Leishmania induced by infection and by immunization with killed parasite antigen: implications for vaccine discovery. Parasites & Vectors, v.9, n.492, 9p, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16490
dc.identifier.issn.pt_BR.fl_str_mv 1756-3305
dc.identifier.doi.none.fl_str_mv 10.1186/s13071-016-1777-x
identifier_str_mv MENDONÇA, Sergio C. F. Differences in immune responses against Leishmania induced by infection and by immunization with killed parasite antigen: implications for vaccine discovery. Parasites & Vectors, v.9, n.492, 9p, 2016.
1756-3305
10.1186/s13071-016-1777-x
url https://www.arca.fiocruz.br/handle/icict/16490
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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