Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control

Detalhes bibliográficos
Autor(a) principal: Rangel, Leonardo da Silva
Data de Publicação: 2023
Outros Autores: Machado, Francisco Paiva, Amaral, Raquel, Silva, Ana Cláudia Rodrigues da, Santos, Marcelo Guerra, Santos, José Augusto Albuquerque dos, Von Ranke, Natalia Lidmar, Rodrigues, Carlos Rangel, Rocha, Leandro, Faria, Robson Xavier
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58970
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Programa de Pós Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil.
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spelling Rangel, Leonardo da SilvaMachado, Francisco PaivaAmaral, RaquelSilva, Ana Cláudia Rodrigues daSantos, Marcelo GuerraSantos, José Augusto Albuquerque dosVon Ranke, Natalia LidmarRodrigues, Carlos RangelRocha, LeandroFaria, Robson Xavier2023-06-07T18:38:08Z2023-06-07T18:38:08Z2023RANGEL, Leonardo da Silva et al. Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control. Frontiers in Pharmacology, v. 14, 1078936, p. 1-11, Feb. 2023.1663-9812https://www.arca.fiocruz.br/handle/icict/5897010.3389/fphar.2023.1078936engFrontiers MediaÓleo essencialNeomitranthes obscuraMoluscicidaBiomphalariaSchistosoma MansoniEssential oilNeomitranthes obscuraMolluskicideBiomphalariaSchistosoma MansoniMolluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis controlinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Programa de Pós Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Laboratório de Tecnologia de Produtos Naturais. Niterói, RJ, Brasil / Universidade Federal do Rio de Janeiro. Programa de Pós Graduação em Biotecnologia Vegetal e Bioprocessos. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Departamento de Ciências. Faculdade de Formação de Professores. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Programa de Pós Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil.Universidade Federal de Amapá. Departamento de Ciências Biológicas e da Saúde. Macapá, AP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Centro de Formação de Professores. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Centro de Formação de Professores. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Programa de Pós Graduação em Biotecnologia Vegetal e Bioprocessos. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Laboratório de Tecnologia de Produtos Naturais. Niterói, RJ, Brasil / Universidade Federal do Rio de Janeiro, Rio de Janeiro/ Universidade Federal Fluminense. Niterói, RJ, Brasil / Universidade Federal do Rio de Janeiro, Programa de Pós Graduação em Biotecnologia Vegetal e Bioprocessos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Programa de Pós Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil.Schistosomiasis is caused by the parasite Schistosoma mansoni, which uses mollusks of the Biomphalaria genus as intermediate hosts. In 2020, approximately 241 million peopleworldwide underwent treatment for schistosomiasis. For this reason, theWorld Health Organization encourages research on alternative molluskicides based on plant species. The objective of this work was to investigate Neomitranthes obscura essential oil from leaf chemical composition and its essential oil nanoemulsion activity on intermediate hosts of schistosomiasis Biomphalaria glabrata control. The major chemical components of the Neomitranthes obscura essential oil were zonarene, seline-3,7(11)-diene, β-selinene, and α-selinene. The nanoemulsion tested using 24- well plate methodology showed lethality and juvenile mollusks with LC90 values of 53.9 and 25.0 ppm after 48 h, respectively, and on their spawning with an LC90 of 66.2 ppm after 48 h. Additionally, the nanoemulsion exhibited an LC90 value against the infective form of the parasite Schistosoma mansoni of 11.5 ppm after 4 h. This pharmaceutical formulation acted inhibiting the acetylcholinesterase activity and was not toxic for Mellanoides sp. This result suggests the use of this nanoformulation as a promising alternative in the control of Biomphalaria glabrata and the transmission of schistosomiasis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58970/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLeonardoRangel_JoseA. Santos_etal_IOC_2023.pdfLeonardoRangel_JoseA. Santos_etal_IOC_2023.pdfapplication/pdf1404759https://www.arca.fiocruz.br/bitstream/icict/58970/2/LeonardoRangel_JoseA.%20Santos_etal_IOC_2023.pdf549ac26fefcc3397187f8ed90bd2d97bMD52icict/589702023-09-04 11:10:23.781oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:10:23Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control
title Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control
spellingShingle Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control
Rangel, Leonardo da Silva
Óleo essencial
Neomitranthes obscura
Moluscicida
Biomphalaria
Schistosoma Mansoni
Essential oil
Neomitranthes obscura
Molluskicide
Biomphalaria
Schistosoma Mansoni
title_short Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control
title_full Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control
title_fullStr Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control
title_full_unstemmed Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control
title_sort Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control
author Rangel, Leonardo da Silva
author_facet Rangel, Leonardo da Silva
Machado, Francisco Paiva
Amaral, Raquel
Silva, Ana Cláudia Rodrigues da
Santos, Marcelo Guerra
Santos, José Augusto Albuquerque dos
Von Ranke, Natalia Lidmar
Rodrigues, Carlos Rangel
Rocha, Leandro
Faria, Robson Xavier
author_role author
author2 Machado, Francisco Paiva
Amaral, Raquel
Silva, Ana Cláudia Rodrigues da
Santos, Marcelo Guerra
Santos, José Augusto Albuquerque dos
Von Ranke, Natalia Lidmar
Rodrigues, Carlos Rangel
Rocha, Leandro
Faria, Robson Xavier
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rangel, Leonardo da Silva
Machado, Francisco Paiva
Amaral, Raquel
Silva, Ana Cláudia Rodrigues da
Santos, Marcelo Guerra
Santos, José Augusto Albuquerque dos
Von Ranke, Natalia Lidmar
Rodrigues, Carlos Rangel
Rocha, Leandro
Faria, Robson Xavier
dc.subject.other.en_US.fl_str_mv Óleo essencial
Neomitranthes obscura
Moluscicida
Biomphalaria
Schistosoma Mansoni
topic Óleo essencial
Neomitranthes obscura
Moluscicida
Biomphalaria
Schistosoma Mansoni
Essential oil
Neomitranthes obscura
Molluskicide
Biomphalaria
Schistosoma Mansoni
dc.subject.en.en_US.fl_str_mv Essential oil
Neomitranthes obscura
Molluskicide
Biomphalaria
Schistosoma Mansoni
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Programa de Pós Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-06-07T18:38:08Z
dc.date.available.fl_str_mv 2023-06-07T18:38:08Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RANGEL, Leonardo da Silva et al. Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control. Frontiers in Pharmacology, v. 14, 1078936, p. 1-11, Feb. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58970
dc.identifier.issn.en_US.fl_str_mv 1663-9812
dc.identifier.doi.none.fl_str_mv 10.3389/fphar.2023.1078936
identifier_str_mv RANGEL, Leonardo da Silva et al. Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control. Frontiers in Pharmacology, v. 14, 1078936, p. 1-11, Feb. 2023.
1663-9812
10.3389/fphar.2023.1078936
url https://www.arca.fiocruz.br/handle/icict/58970
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58970/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/58970/2/LeonardoRangel_JoseA.%20Santos_etal_IOC_2023.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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