Timeline kinetics of systemic and airway immune mediator storm for comprehensive analysis of disease outcome in critically ill COVID-19 patients
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/55590 |
Resumo: | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. |
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Gonçalves, Juan JonathanMata, Camila Pacheco Silveira Martins daLourenço, Alice AparecidaRibeiro, Ágata LopesFerreira, Geovane MarquesFraga-Silva, Thais Fernanda de CamposSouza, Fernanda Mesquita deAlmeida, Vanessa Egídio SilveiraBatista, Iara AntunesAvila-Mesquita, Carolina D.Couto, Ariel E. S.Campos, Ligia C. B.Paim, Adriana Alves OliveiraFerreira, Linziane LopesOliveira, Patrícia de MeloTeixeira, Lorena de AlmeidaMarques, Daisymara Priscila de AlmeidaMoraes, Henrique Retes dePereira, Samille HenriquesBrito-de-Sousa, Joaquim PedroAzevedo, Ana Carolina CampiPaschoal, Vanessa Peruhype MagalhãesAraújo, Márcio Sobreira SilvaCarvalho, Andréa Teixeira deFonseca, Flávio Guimarães daBonato, Vânia Luiza DeperonBecari, ChristianeFerro, DeniseMenegueti, Mayra GonçalvesMazzoni, Amanda Alves SilvaMartins, Maria AuxiliadoraCoelho-Dos-Reis, Jordana GrazzielaMartins Filho, Olindo Assis2022-11-11T13:38:42Z2022-11-11T13:38:42Z2022GONÇALVES, Juan Jonathan et al. Timeline kinetics of systemic and airway immune mediator storm for comprehensive analysis of disease outcome in critically ill COVID-19 patients. Frontiers in Immunology, v. 13, p. 1-15, 3 June 2022.1664-3224https://www.arca.fiocruz.br/handle/icict/5559010.3389/fimmu.2022.9039031664-3224engFrontiers MediaTimeline kinetics of systemic and airway immune mediator storm for comprehensive analysis of disease outcome in critically ill COVID-19 patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Hospital Risoleta Tolentino Neves. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Hospital Risoleta Tolentino Neves. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Hospital Risoleta Tolentino Neves. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Hospital Risoleta Tolentino Neves. Belo Horizonte, MG, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil.Universidade Federal de Minas Gerais. Hospital Risoleta Tolentino Neves. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Hospital Risoleta Tolentino Neves. Belo Horizonte, MG, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Vascular. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Vascular. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Vascular. Ribeirão Preto, SP, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Centro de Tecnologia em Vacinas. Belo Horizonte, MG, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil / Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Cirurgia Vascular. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Enfermagem de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Escola de Enfermagem de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Medicina Intensiva. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Divisão de Medicina Intensiva. Ribeirão Preto, SP, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.In the present study, the levels of serum and airway soluble chemokines, pro-inflammatory/regulatory cytokines, and growth factors were quantified in critically ill COVID-19 patients (total n=286) at distinct time points (D0, D2-6, D7, D8-13 and D>14-36) upon Intensive Care Unit (ICU) admission. Augmented levels of soluble mediators were observed in serum from COVID-19 patients who progress to death. An opposite profile was observed in tracheal aspirate samples, indicating that systemic and airway microenvironment diverge in their inflammatory milieu. While a bimodal distribution was observed in the serum samples, a unimodal peak around D7 was found for most soluble mediators in tracheal aspirate samples. Systems biology tools further demonstrated that COVID-19 display distinct eccentric soluble mediator networks as compared to controls, with opposite profiles in serum and tracheal aspirates. Regardless the systemic-compartmentalized microenvironment, networks from patients progressing to death were linked to a pro-inflammatory/growth factor-rich, highly integrated center. Conversely, patients evolving to discharge exhibited networks of weak central architecture, with lower number of neighborhood connections and clusters of pro-inflammatory and regulatory cytokines. All in all, this investigation with robust sample size landed a comprehensive snapshot of the systemic and local divergencies composed of distinct immune responses driven by SARS-CoV-2 early on severe COVID-19.COVID-19CytokinesChemokinesGrowth factorsPrognostic biomarkersSystemicAirwayImmune mediatorsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55590/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTimeline Kinetics of Systemic and Airway Immune Mediator .pdfTimeline Kinetics of Systemic and Airway Immune Mediator .pdfapplication/pdf8991627https://www.arca.fiocruz.br/bitstream/icict/55590/2/Timeline%20Kinetics%20of%20Systemic%20and%20Airway%20Immune%20Mediator%20.pdfeeb4ec449e2c4a173c9af110f95fa757MD52icict/555902022-11-18 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| dc.title.en_US.fl_str_mv |
Timeline kinetics of systemic and airway immune mediator storm for comprehensive analysis of disease outcome in critically ill COVID-19 patients |
| title |
Timeline kinetics of systemic and airway immune mediator storm for comprehensive analysis of disease outcome in critically ill COVID-19 patients |
| spellingShingle |
Timeline kinetics of systemic and airway immune mediator storm for comprehensive analysis of disease outcome in critically ill COVID-19 patients Gonçalves, Juan Jonathan COVID-19 Cytokines Chemokines Growth factors Prognostic biomarkers Systemic Airway Immune mediators |
| title_short |
Timeline kinetics of systemic and airway immune mediator storm for comprehensive analysis of disease outcome in critically ill COVID-19 patients |
| title_full |
Timeline kinetics of systemic and airway immune mediator storm for comprehensive analysis of disease outcome in critically ill COVID-19 patients |
| title_fullStr |
Timeline kinetics of systemic and airway immune mediator storm for comprehensive analysis of disease outcome in critically ill COVID-19 patients |
| title_full_unstemmed |
Timeline kinetics of systemic and airway immune mediator storm for comprehensive analysis of disease outcome in critically ill COVID-19 patients |
| title_sort |
Timeline kinetics of systemic and airway immune mediator storm for comprehensive analysis of disease outcome in critically ill COVID-19 patients |
| author |
Gonçalves, Juan Jonathan |
| author_facet |
Gonçalves, Juan Jonathan Mata, Camila Pacheco Silveira Martins da Lourenço, Alice Aparecida Ribeiro, Ágata Lopes Ferreira, Geovane Marques Fraga-Silva, Thais Fernanda de Campos Souza, Fernanda Mesquita de Almeida, Vanessa Egídio Silveira Batista, Iara Antunes Avila-Mesquita, Carolina D. Couto, Ariel E. S. Campos, Ligia C. B. Paim, Adriana Alves Oliveira Ferreira, Linziane Lopes Oliveira, Patrícia de Melo Teixeira, Lorena de Almeida Marques, Daisymara Priscila de Almeida Moraes, Henrique Retes de Pereira, Samille Henriques Brito-de-Sousa, Joaquim Pedro Azevedo, Ana Carolina Campi Paschoal, Vanessa Peruhype Magalhães Araújo, Márcio Sobreira Silva Carvalho, Andréa Teixeira de Fonseca, Flávio Guimarães da Bonato, Vânia Luiza Deperon Becari, Christiane Ferro, Denise Menegueti, Mayra Gonçalves Mazzoni, Amanda Alves Silva Martins, Maria Auxiliadora Coelho-Dos-Reis, Jordana Grazziela Martins Filho, Olindo Assis |
| author_role |
author |
| author2 |
Mata, Camila Pacheco Silveira Martins da Lourenço, Alice Aparecida Ribeiro, Ágata Lopes Ferreira, Geovane Marques Fraga-Silva, Thais Fernanda de Campos Souza, Fernanda Mesquita de Almeida, Vanessa Egídio Silveira Batista, Iara Antunes Avila-Mesquita, Carolina D. Couto, Ariel E. S. Campos, Ligia C. B. Paim, Adriana Alves Oliveira Ferreira, Linziane Lopes Oliveira, Patrícia de Melo Teixeira, Lorena de Almeida Marques, Daisymara Priscila de Almeida Moraes, Henrique Retes de Pereira, Samille Henriques Brito-de-Sousa, Joaquim Pedro Azevedo, Ana Carolina Campi Paschoal, Vanessa Peruhype Magalhães Araújo, Márcio Sobreira Silva Carvalho, Andréa Teixeira de Fonseca, Flávio Guimarães da Bonato, Vânia Luiza Deperon Becari, Christiane Ferro, Denise Menegueti, Mayra Gonçalves Mazzoni, Amanda Alves Silva Martins, Maria Auxiliadora Coelho-Dos-Reis, Jordana Grazziela Martins Filho, Olindo Assis |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gonçalves, Juan Jonathan Mata, Camila Pacheco Silveira Martins da Lourenço, Alice Aparecida Ribeiro, Ágata Lopes Ferreira, Geovane Marques Fraga-Silva, Thais Fernanda de Campos Souza, Fernanda Mesquita de Almeida, Vanessa Egídio Silveira Batista, Iara Antunes Avila-Mesquita, Carolina D. Couto, Ariel E. S. Campos, Ligia C. B. Paim, Adriana Alves Oliveira Ferreira, Linziane Lopes Oliveira, Patrícia de Melo Teixeira, Lorena de Almeida Marques, Daisymara Priscila de Almeida Moraes, Henrique Retes de Pereira, Samille Henriques Brito-de-Sousa, Joaquim Pedro Azevedo, Ana Carolina Campi Paschoal, Vanessa Peruhype Magalhães Araújo, Márcio Sobreira Silva Carvalho, Andréa Teixeira de Fonseca, Flávio Guimarães da Bonato, Vânia Luiza Deperon Becari, Christiane Ferro, Denise Menegueti, Mayra Gonçalves Mazzoni, Amanda Alves Silva Martins, Maria Auxiliadora Coelho-Dos-Reis, Jordana Grazziela Martins Filho, Olindo Assis |
| dc.subject.en.en_US.fl_str_mv |
COVID-19 Cytokines Chemokines Growth factors Prognostic biomarkers Systemic Airway Immune mediators |
| topic |
COVID-19 Cytokines Chemokines Growth factors Prognostic biomarkers Systemic Airway Immune mediators |
| description |
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. |
| publishDate |
2022 |
| dc.date.accessioned.fl_str_mv |
2022-11-11T13:38:42Z |
| dc.date.available.fl_str_mv |
2022-11-11T13:38:42Z |
| dc.date.issued.fl_str_mv |
2022 |
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info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
GONÇALVES, Juan Jonathan et al. Timeline kinetics of systemic and airway immune mediator storm for comprehensive analysis of disease outcome in critically ill COVID-19 patients. Frontiers in Immunology, v. 13, p. 1-15, 3 June 2022. |
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https://www.arca.fiocruz.br/handle/icict/55590 |
| dc.identifier.issn.en_US.fl_str_mv |
1664-3224 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fimmu.2022.903903 |
| dc.identifier.eissn.none.fl_str_mv |
1664-3224 |
| identifier_str_mv |
GONÇALVES, Juan Jonathan et al. Timeline kinetics of systemic and airway immune mediator storm for comprehensive analysis of disease outcome in critically ill COVID-19 patients. Frontiers in Immunology, v. 13, p. 1-15, 3 June 2022. 1664-3224 10.3389/fimmu.2022.903903 |
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https://www.arca.fiocruz.br/handle/icict/55590 |
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eng |
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eng |
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Frontiers Media |
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Frontiers Media |
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| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 eeb4ec449e2c4a173c9af110f95fa757 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324654664843264 |