Control of lymphocyte adhesion to brain and aortic endothelium: ICAM-1, VCAM-1 and negative charge

Detalhes bibliográficos
Autor(a) principal: dosSantos, Washington Luis Conrado
Data de Publicação: 1996
Outros Autores: Rahman, Jameel, Klein, Nigel, Male, David K
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20044
Resumo: dosSantos, Washington Luis Conrado “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling dosSantos, Washington Luis ConradoRahman, JameelKlein, NigelMale, David K2017-07-11T17:03:09Z2017-07-11T17:03:09Z1996dosSANTOS, W. L. C. et al. Control of lymphocyte adhesion to brain and aortic endothelium: ICAM-1, VCAM-1 and negative charge. Journal of Neuroimmunology, v. 66, p. 125-134, 1996.0165-5728https://www.arca.fiocruz.br/handle/icict/20044dosSantos, Washington Luis Conrado “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.CNPQ (Brasil) and Jameel Rahman was supported by a grant from the Multiple Sclerosis Society of Great Britain.Institute of Psychiatry. Department of Neuropathology. London, UKInstitute of Psychiatry. Department of Neuropathology. London, UKInstitute of Child Health. Molecular Immunology Unit. London, UKInstitute of Psychiatry. Department of Neuropathology. London, UKLymphocyte adhesion to CI\TS endothelium is low by comparison with non-CNS endothelium. It has been proposed that this could be due to the high surface charge of brain endothelium, or a low constitutive expression of adhesion molecules. In this study we compared the influence of these factors on lymphocyte adhesion to BEC and aortic endothelium (AEC) in culture. Brain endothelium expresses very low levels of VCAM-1, and lower levels of ICAM- than aortic endothelium. The negative charge differed between the endothelia, but this had a minimal effect on lymphocyte adhesion. The anionic sites were, however, more stable on brain endothelium, remaining unchanged after endothelial cell activation with cytokines, while redistribution was observed on cytokine-activated aortic endothelium.engElsevierEndotélioVCAMICAM-lLinfocitosEndotheliumVCAM- l/VLA-4ICAM-l/LFAlNegative chargeLymphocyte adhesionControl of lymphocyte adhesion to brain and aortic endothelium: ICAM-1, VCAM-1 and negative chargeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20044/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALdos Santos WLC Control of lymphocyte....pdfdos Santos WLC Control of 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dc.title.pt_BR.fl_str_mv Control of lymphocyte adhesion to brain and aortic endothelium: ICAM-1, VCAM-1 and negative charge
title Control of lymphocyte adhesion to brain and aortic endothelium: ICAM-1, VCAM-1 and negative charge
spellingShingle Control of lymphocyte adhesion to brain and aortic endothelium: ICAM-1, VCAM-1 and negative charge
dosSantos, Washington Luis Conrado
Endotélio
VCAM
ICAM-l
Linfocitos
Endothelium
VCAM- l/VLA-4
ICAM-l/LFAl
Negative charge
Lymphocyte adhesion
title_short Control of lymphocyte adhesion to brain and aortic endothelium: ICAM-1, VCAM-1 and negative charge
title_full Control of lymphocyte adhesion to brain and aortic endothelium: ICAM-1, VCAM-1 and negative charge
title_fullStr Control of lymphocyte adhesion to brain and aortic endothelium: ICAM-1, VCAM-1 and negative charge
title_full_unstemmed Control of lymphocyte adhesion to brain and aortic endothelium: ICAM-1, VCAM-1 and negative charge
title_sort Control of lymphocyte adhesion to brain and aortic endothelium: ICAM-1, VCAM-1 and negative charge
author dosSantos, Washington Luis Conrado
author_facet dosSantos, Washington Luis Conrado
Rahman, Jameel
Klein, Nigel
Male, David K
author_role author
author2 Rahman, Jameel
Klein, Nigel
Male, David K
author2_role author
author
author
dc.contributor.author.fl_str_mv dosSantos, Washington Luis Conrado
Rahman, Jameel
Klein, Nigel
Male, David K
dc.subject.other.pt_BR.fl_str_mv Endotélio
VCAM
ICAM-l
Linfocitos
topic Endotélio
VCAM
ICAM-l
Linfocitos
Endothelium
VCAM- l/VLA-4
ICAM-l/LFAl
Negative charge
Lymphocyte adhesion
dc.subject.en.pt_BR.fl_str_mv Endothelium
VCAM- l/VLA-4
ICAM-l/LFAl
Negative charge
Lymphocyte adhesion
description dosSantos, Washington Luis Conrado “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 1996
dc.date.issued.fl_str_mv 1996
dc.date.accessioned.fl_str_mv 2017-07-11T17:03:09Z
dc.date.available.fl_str_mv 2017-07-11T17:03:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv dosSANTOS, W. L. C. et al. Control of lymphocyte adhesion to brain and aortic endothelium: ICAM-1, VCAM-1 and negative charge. Journal of Neuroimmunology, v. 66, p. 125-134, 1996.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20044
dc.identifier.issn.pt_BR.fl_str_mv 0165-5728
identifier_str_mv dosSANTOS, W. L. C. et al. Control of lymphocyte adhesion to brain and aortic endothelium: ICAM-1, VCAM-1 and negative charge. Journal of Neuroimmunology, v. 66, p. 125-134, 1996.
0165-5728
url https://www.arca.fiocruz.br/handle/icict/20044
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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